{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:55:54Z","timestamp":1793796954953,"version":"4.6.1"},"reference-count":58,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30DK020572"],"award-info":[{"award-number":["P30DK020572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01DK135799"],"award-info":[{"award-number":["K01DK135799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DK130913"],"award-info":[{"award-number":["R01DK130913"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0011633"],"award-info":[{"award-number":["NNF14OC0011633"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Diabetic peripheral neuropathy (DPN), a severe complication of Type 2 diabetes (T2D), is marked by progressive distal\u2010to\u2010proximal axonal degeneration. Although animal models have advanced our understanding of DPN pathogenesis, preclinical successes rarely translate into effective therapies, underscoring the need for models that more faithfully mirror human disease. In this study, we characterized two polygenic mouse strains, NONcNZO10\/LtJ (RCS10) and TALLYHO\/JngJ (TH), and found that both models developed obesity, hyperglycemia, dyslipidemia, and DPN by 24\u2009weeks of age. However, hyperinsulinemia was observed only in RCS10 mice. Compared to monogenic and high\u2010fat diet\u2010induced models, the metabolic and neuropathic phenotypes of RCS10 and TH more closely resembled those of human DPN. In the second phase of the study, RCS10 mice were subjected to a calorie\u2010restricted diet (60% of standard intake) for 8\u2009weeks, which improved metabolic health and restored large fiber function, although intraepidermal nerve fiber density remained unchanged. Together, these findings identify RCS10 and TH mice as clinically relevant polygenic models for studying DPN pathogenesis and evaluating targeted therapeutic strategies.<\/jats:p>","DOI":"10.1096\/fj.202600848r","type":"journal-article","created":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T08:38:01Z","timestamp":1788597481000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["<scp>NONcNZO10<\/scp>\n                    \/\n                    <scp>LtJ<\/scp>\n                    and\n                    <scp>TALLY<\/scp>\n                    \u2010\n                    <scp>HO<\/scp>\n                    \/\n                    <scp>JngJ<\/scp>\n                    Mice as Novel Models of Diabetic Peripheral Neuropathy"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-7544","authenticated-orcid":false,"given":"St\u00e9phanie A.","family":"Eid","sequence":"first","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"},{"name":"Department of Anatomy, Cell Biology and Physiological Sciences American University of Beirut  Faculty of Medicine and Medical Center, Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Carter","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily J.","family":"Koubek","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Hayes","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana M.","family":"Rigan","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chloe","family":"Kiriluk","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crystal M.","family":"Pacut","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillipe D.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihyun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7966-1322","authenticated-orcid":false,"given":"Dae\u2010Gyu","family":"Jang","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9162-2694","authenticated-orcid":false,"given":"Eva L.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Michigan  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.2991\/jegh.k.191028.001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-024-01041-y"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.05.003"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(22)00188-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.049337"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ilar\/ilt052"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology9110347"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2014.10.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.03.011"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00594.2004"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.2174\/1573399810666140508121012"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/848307"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.042101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.028530"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3173-18.2019"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2007.S4"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00376.2006"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.2001.6569"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.1.06647"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.037374"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db23-0997"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300354R"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12979-022-00323-7"},{"key":"e_1_2_10_25_1","volume-title":"MMPC Protocols","author":"Feldman E. L.","year":"2009"},{"key":"e_1_2_10_26_1","volume-title":"MMPC Protocols","author":"Feldman E. L.","year":"2016"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.050080"},{"key":"e_1_2_10_28_1","unstructured":"M.D'Orazio \u201cStatistical Matching and Imputation of Survey Data with StatMatch \u201d(2014) https:\/\/CRAN.R\u2010project.org\/package=StatMatch."},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12072"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-62703-068-7_6"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-448-3_1"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00689757"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13098-025-02015-w"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11886-021-01455-w"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2024.100706"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15022991"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-37376-y"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1771"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51367"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2021.0155"},{"key":"e_1_2_10_41_1","first-page":"1","article-title":"Differential Effects of Minocycline on Microvascular Complications in Murine Models of Type 1 and Type 2 Diabetes","volume":"7","author":"Eid S. A.","year":"2021","journal-title":"Journal of Translational Science"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002387R"},{"key":"e_1_2_10_43_1","article-title":"Association of Anthropometry With Nerve Conduction Parameters of Median Nerve: A Cross\u2010Sectional Study in a North Indian Medical University Hospital","volume":"16","author":"Singh R.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_10_44_1","article-title":"Nerve Conduction Study in Healthy Elderly Subjects in Central India: A Cross\u2010Sectional Study","volume":"14","author":"Taksande A. B.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-90-3-298"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.2147\/DMSO.S334767"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-2277"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.531"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003682"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12944-023-01873-5"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101679"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-019-00607-x"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2018.05.011"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0574"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2309108"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-0224"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/oby.23246"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.048909"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdiacomp.2015.09.018"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202600848R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202600848R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202600848R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:51:19Z","timestamp":1793580679000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202600848R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,5]]},"references-count":58,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1096\/fj.202600848R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202600848r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,5]]},"assertion":[{"value":"2026-02-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-05","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72275"}}