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Its pathophysiology involves complex interactions between the virus and the host, including the immune response and the vascular endothelium. In this context, platelets play roles beyond hemostasis, acting as key immunomodulatory cells involved in inflammation and the regulation of vascular permeability. Therefore, this review summarizes and discusses the so called classic and non\u2010classic platelet\u2010related and endothelial biomarkers described in dengue virus infection. Classical biomarkers include P\u2010selectin (CD62P), PF4\/CXCL4, RANTES\/CCL5, CD40L, IL\u20101\u03b2, VEGF, integrin \u03b1IIb\u03b23, CD63, and platelet extracellular vesicles, all supported by broad experimental and clinical evidence. Non\u2010classical or emerging biomarkers include TLT\u20101, TREM\u20101\/sTREM\u20101, angiopoietins (Ang\u20101\/Ang\u20102), serotonin, ferritin, dengue virus envelope domain III (EIII), and soluble endothelial molecules such as IL\u20101RA, sCD163, SDC\u20101, sVCAM\u20101, IL\u20108, and IP\u201010. Alone or in combination, these markers can be used\/explored as prognostic tools and\/or as therapeutic targets. Finally, integrating multimarker panels encompassing hemostatic, inflammatory, and endothelial pathways may improve prognostic stratification. This approach could support targeted interventions and help reduce complications such as thrombocytopenia, plasma leakage, and dengue shock.<\/jats:p>","DOI":"10.1096\/fj.202600884rr","type":"journal-article","created":{"date-parts":[[2026,6,22]],"date-time":"2026-06-22T10:58:16Z","timestamp":1782125896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Beyond Hemostasis: Platelet Biomarkers and Vascular\u2010Immune Crosstalk in Dengue"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-6478-2362","authenticated-orcid":false,"given":"Amanda Beatriz Adriano","family":"da Silva\u2010Alencar","sequence":"first","affiliation":[{"name":"Institute of Tropical Pathology and Public Health Federal University of Goi\u00e1s  Goi\u00e2nia Goi\u00e1s 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