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Long noncoding RNAs (lncRNAs) have emerged as important regulators of muscle development and regeneration, yet how lncRNAs integrate with canonical signaling networks to shape myogenic progression remains incompletely defined. Here, we identify a novel myocyte\u2010enriched, Notch\u2010repressed myogenic lncRNA (\n                    <jats:italic>NRMLncR,<\/jats:italic>\n                    known as\n                    <jats:italic>A930003A15Rik<\/jats:italic>\n                    ), as a previously uncharacterized regulator of mouse myogenesis. The expression of\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    is robustly induced during primary myoblast activation and differentiation. Loss\u2010of\u2010function analyses show that knockdown of\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    impairs myogenic differentiation, accompanied by reduced expression of key myogenic genes. In contrast, adenovirus\u2010mediated overexpression of\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    enhances myogenic differentiation in\u00a0vitro and is associated with increased muscle fiber size in\u00a0vivo. Mechanistically, MyoD and MyoG occupy the\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    promoter and promote its transcription during myogenic differentiation.\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    knockdown alerts the transcription of nearby genes, suggesting its function through a cis\u2010regulatory mechanism. RNA pull\u2010down and functional assays further identify an interaction between\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    and the RNA\u2010binding protein CELF1. Together, these findings establish\n                    <jats:italic>NRMLncR<\/jats:italic>\n                    as a novel Notch\u2010associated lncRNA that promotes myogenic differentiation and provide insight into lncRNA\u2010dependent regulation of the myogenic program.\n                  <\/jats:p>","DOI":"10.1096\/fj.202601027r","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T15:55:36Z","timestamp":1782921336000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Myocyte\u2010Enriched Long Non\u2010Coding\n                    <scp>RNA<\/scp>\n                    <i>NRMLncR<\/i>\n                    Enhances Myogenesis in Mouse"],"prefix":"10.1096","volume":"40","author":[{"given":"Yufen","family":"Li","sequence":"first","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumei","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing Ying","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Arrington","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Purdue University  West Lafayette Indiana USA"},{"name":"Mass Spectrometry Core Salk Institute for Biological Studies  La Jolla California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzheng","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Molecular Genetics &amp; Microbiology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mostafa F.","family":"Abdelhai","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junxiao","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yung\u2010Yu","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Animal Sciences University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology University of Florida  Gainesville Florida USA"},{"name":"UF Genetics Institute University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W. 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