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The bradykinin B2 receptor (B2R) is constitutively expressed in the brain, where it may modulate neuronal differentiation, neuroplasticity, and behavioral aspects. Here, we investigated the functional role of striatal B2R by conditionally deleting the\n                    <jats:italic>Bdkrb2<\/jats:italic>\n                    gene in the dorsal striatum of adult male mice (\n                    <jats:italic>Bdkrb2<\/jats:italic>\n                    <jats:sup>flox\/flox<\/jats:sup>\n                    ) using bilateral stereotaxic injections of an AAV8 that induces Cre and tdTomato expression. Mice lacking B2R in the dorsal striatum displayed several context\u2010dependent behavioral alterations, such as reduced anxiety\u2010like behavior and decreased sucrose preference. Moreover, these animals showed enhanced voluntary wheel running, suggesting alterations in motivation\u2010related behavioral output. Immunofluorescence analysis revealed that among dTomato\u2010positive neurons, approximately 17% co\u2010expressed DARPP\u201032, indicating that a subset of the transduced cells corresponds to dopaminoceptive medium spiny neurons. Together, these findings show that dorsal striatal B2R deletion alters anxiety\u2010related and motivational\/hedonic behaviors in male mice and suggest that these effects may involve striatal neuronal populations, including a subset of dopaminoceptive neurons.\n                  <\/jats:p>","DOI":"10.1096\/fj.202601142rr","type":"journal-article","created":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T11:14:16Z","timestamp":1779362056000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Loss of Striatal Bradykinin\n                    <scp>B2<\/scp>\n                    Receptor Alters Anxiety and Motivational Behaviors in Male Mice"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6317-6853","authenticated-orcid":false,"given":"Mariana Rosolen","family":"Tavares","sequence":"first","affiliation":[{"name":"Department of Neurology and Neurosurgery Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronaldo Carvalho","family":"Araujo","sequence":"additional","affiliation":[{"name":"Department of Biophysics Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina Galleazzo","family":"Martins","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"Jose","family":"Donato","sequence":"additional","affiliation":[{"name":"Department of Physiology and Biophysics, Instituto de Ciencias Biomedicas Universidade de Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Bader","sequence":"additional","affiliation":[{"name":"Max\u2010Delbr\u00fcck Center for Molecular Medicine (MDC)  Berlin Germany"},{"name":"German Center for Cardiovascular Research (DZHK)  Berlin Germany"},{"name":"Institute for Biology University of L\u00fcbeck  L\u00fcbeck Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederick","family":"Wasinski","sequence":"additional","affiliation":[{"name":"Department of Neurology and Neurosurgery Federal University of Sao Paulo  Sao Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,21]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.79.6.2106"},{"issue":"2","key":"e_1_2_11_3_1","first-page":"H876","article-title":"In Vivo B2\u2010Receptor\u2010Mediated Negative Chronotropic Effect of Bradykinin in Canine Sinus Node","volume":"265","author":"Ribuot C.","year":"1993","journal-title":"American Journal of 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