{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:46:52Z","timestamp":1791809212265,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["113S376"],"award-info":[{"award-number":["113S376"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,10,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Nonvisual\n                    <jats:italic>arrestins<\/jats:italic>\n                    , also known as Beta\u2010arrestins, are known for their diverse role in GPCR signal transduction. Here, we present evidence that Beta\u2010Arrestin\u20102, a protein whose nuclear concentration is actively kept low, binds to Nucleolar Organizing Regions (NORs) on the metaphase chromosomes at the onset of cell division, after the disappearance of the nuclear membrane and stays bound therein in the daughter cells. After reformation of the nucleoli, it stays bound to the nucleoli until actively transported out of the reformed nucleus during interphase. This binding is unique for Beta\u2010Arrestin\u20102, as the closely associated Beta\u2010Arrestin\u20101 does not show this behavior at all. We also observed an intranuclear accumulation of Beta\u2010Arrestin\u20102 after P2X7 receptor stimulation, similar to what has been described for Beta\u2010Arrestin\u20102 after TRPV receptor stimulation. Present data identify a cyclic and well\u2010organized shuttling between NORs and the cytoplasm of Beta\u2010Arrestin\u20102 during cell division, indicating a novel and unknown role for Beta\u2010Arrestin\u20102 in cell physiology. Our data may also indicate a common intracellular signaling mechanism for a diverse group of receptors currently believed to function only as ligand\u2010gated channels (P2X7 and TRPV).\n                  <\/jats:p>","DOI":"10.1096\/fj.202601209rr","type":"journal-article","created":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:57:00Z","timestamp":1791471420000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Beta\u2010Arrestin\u20102 Binds to Nucleolar Organizing Regions With\n                    <scp>P2X7<\/scp>\n                    Receptor Stimulation and During Cell Division"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0763-3949","authenticated-orcid":false,"given":"Tu\u011fba","family":"G\u00fcm\u00fc\u015fta\u015f","sequence":"first","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seda","family":"Uysal","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ida","family":"Casella","sequence":"additional","affiliation":[{"name":"Dip.\u00a0Farmaco Istituto Superiore di Sanita  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00d6zlem","family":"U\u011fur","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, Faculty of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehmet","family":"U\u011fur","sequence":"additional","affiliation":[{"name":"Department of Biophysics, Faculty of Medicine Ankara University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.2163110"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2011.05.002"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2006.11.007"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000302"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aav0711"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052280"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0704849104"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.062521"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M207552200"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M910348199"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M208109200"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.06.020"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-051116-052406"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00793"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.133.2.235"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2184"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.059923"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.059410"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.030163"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.11.4.1421"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.33.23263"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603659200"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.4161\/nucl.11334"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200405013"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.4161\/nucl.2.3.16246"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2012.08.018"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2102"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-001-0792-0"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.12.012"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e13-04-0223"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-026-10539-y"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.7"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10879"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.07.043"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2007.02.003"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202601209RR","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202601209RR","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202601209RR","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T12:08:59Z","timestamp":1791806939000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202601209RR"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,8]]},"references-count":35,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10,15]]}},"alternative-id":["10.1096\/fj.202601209RR"],"URL":"https:\/\/doi.org\/10.1096\/fj.202601209rr","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,8]]},"assertion":[{"value":"2026-03-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72325"}}