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Here, we demonstrate that suppressor of cytokine signaling 3 (\n                    <jats:italic>SOCS3<\/jats:italic>\n                    ) plays a pivotal role in regulating avian adipogenesis by modulating adipogenic transcriptional programs. Multiplex immunofluorescence revealed that SOCS3 is enriched in PDGFR\u03b1\n                    <jats:sup>+<\/jats:sup>\n                    preadipocytes within abdominal fat but declines during late differentiation. Functional studies in primary adipocytes and ICP1 cell line showed that\n                    <jats:italic>SOCS3<\/jats:italic>\n                    knockdown promotes, whereas overexpression inhibits, adipogenic differentiation. Transcriptomic profiling indicated that\n                    <jats:italic>SOCS3<\/jats:italic>\n                    depletion remodels the adipogenic transcriptional landscape, upregulating adipogenic and metabolic genes while downregulating transcriptional inhibitors. Mechanistically, proteomic analyses and co\u2010immunoprecipitation identified poly(ADP\u2010ribose) polymerase 1 (PARP1) as a SOCS3\u2010binding partner. SOCS3 stabilizes PARP1 by suppressing its ubiquitination, leading to increased PAR levels and inhibition of adipogenesis. PARP1 interacts with PPAR\u03b3 and represses its transcriptional activity through a mechanism independent of enzymatic PARylation. Importantly, ligand activation of PPAR\u03b3 weakens its interaction with PARP1 and alleviates PARP1\u2010mediated repression of its transcriptional activity. Collectively, these findings reveal a previously unrecognized\n                    <jats:italic>SOCS3<\/jats:italic>\n                    \/\n                    <jats:italic>PARP1<\/jats:italic>\n                    axis that modulates the transcriptional programs driving chicken adipocyte differentiation, underscoring its critical role in adipogenesis.\n                  <\/jats:p>","DOI":"10.1096\/fj.202601300rr","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:51:22Z","timestamp":1784130682000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>SOCS3<\/scp>\n                    Stabilizes\n                    <scp>PARP1<\/scp>\n                    to Suppress Adipogenic Transcription and Abdominal Adipogenesis in Avian"],"prefix":"10.1096","volume":"40","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taiyuan China"},{"name":"National Engineering Laboratory for Animal Breeding and Key Laboratory of Animal Genetics, Breeding and Reproduction, MARA, College of Animal Science and Technology China Agricultural University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zixuan","family":"Tian","sequence":"additional","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liuying","family":"Qv","sequence":"additional","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyu","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Life Science Shanxi Agricultural University  Taiyuan 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