{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T09:23:55Z","timestamp":1787822635875,"version":"build-2784847793"},"reference-count":50,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,8,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Taraxerol (Tar) is a natural triterpenoid which exhibited anti\u2010inflammatory and neuroprotective properties. Whereas, the roles of Tar in cerebral ischemia\u2013reperfusion injury (CIRI) remain incompletely understood. The research investigated the protective effects and regulatory mechanism of Tar in CIRI. The middle cerebral artery occlusion (MCAO) model was established in\u00a0vivo. Effects of Tar on brain injury and MCAO rats motor function were detected by HE staining and TUNEL assay. PC12 cells were subjected to oxygen\u2013glucose deprivation\/reoxygenation (OGD\/R) and irritated with 20, 40, 80, and 160\u2009\u03bcM Tar; the intracellular Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , MDA, and ROS levels were detected utilizing interrelated assay kits. The pro\u2010inflammatory cytokines and ferroptosis\u2010related factors were examined through qRT\u2010PCR and western blot assay. Cell viability and apoptosis of PC12 cells were examined by CCK\u20108 and flow cytometry assays. The AKT agonist (SC79) was used to investigate the regulatory functions of the AKT\/NF\u2010\u03baB pathway in OGD\/R\u2010treated PC12 cells. Tar alleviated brain injury and motor function in MCAO rats. Tar eased inflammation, oxidative stress, and ferroptosis in MCAO rats. In\u00a0vitro, OGD\/R exposure reduced cell viability, promoted apoptosis, elevated IFN\u2010\u03b3, TNF\u2010\u03b1, IL\u20106, Fe\n                    <jats:sup>2+<\/jats:sup>\n                    , MDA, and ROS levels but declined GPX4 and SLC7A11 in PC12 cells. But, the above\u2010mentioned tendency of OGD\/R\u2010triggered PC12 cells injury was overturned by Tar. Mechanistically, Tar treatment inactivated the AKT\/NF\u2010\u03baB pathway and decreased nuclear translocation of NF\u2010\u03baB in OGD\/R\u2010induced PC12 cells. The AKT agonist SC79 reversed the protective effects of Tar in OGD\/R\u2010induced PC12 cells. Tar improved CIRI induced inflammation and ferroptosis through regulating the AKT\/NF\u2010\u03baB pathway.\n                  <\/jats:p>","DOI":"10.1096\/fj.202601724r","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T15:33:52Z","timestamp":1787672032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Taraxerol Alleviates Cerebral Ischemia\u2013Reperfusion Induced Inflammation and Ferroptosis via Regulating\n                    <scp>AKT<\/scp>\n                    \/\n                    <scp>NF<\/scp>\n                    \u2010\n                    <scp>\u03baB<\/scp>\n                    Pathway"],"prefix":"10.1096","volume":"40","author":[{"given":"Zhengfei","family":"Yang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Ningxia Medical University  Yinchuan Ningxia China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-9495-731X","authenticated-orcid":false,"given":"Zhenwu","family":"Zhao","sequence":"additional","affiliation":[{"name":"Emergency Department Beijing University of Chinese Medicine Third Affiliated Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.049013"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.314674.118"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2024.155701"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15807"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2020.12.018"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2174\/0122103155277711231204060922"},{"issue":"4","key":"e_1_2_10_8_1","first-page":"807","article-title":"The Biosynthesis and Medicinal Properties of Taraxerol","volume":"10","author":"Mus A.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.2174\/0122103155277711231204060922"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-025-10391-w"},{"issue":"15","key":"e_1_2_10_11_1","first-page":"4321","article-title":"Taraxasterol Protects Hippocampal Neurons From Oxygen\u2010Glucose Deprivation\/Reoxygenation\u2010Induced Injury Through Activation of Nrf2 Signalling Pathway","volume":"29","author":"Li Y.","year":"2025","journal-title":"Journal of Cellular and Molecular Medicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.steroids.2018.01.002"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6643382"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177505"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2021.633610"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-024-04039-1"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/NRR.NRR-D-24-00568"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23544"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177004"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03046-2"},{"key":"e_1_2_10_21_1","doi-asserted-by":"crossref","unstructured":"A. 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