{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T17:01:38Z","timestamp":1782320498100,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,6,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Preeclampsia (PE) is a major cause of maternal and perinatal morbidity. Because abnormal fat distribution is closely related to metabolic dysfunction, vascular injury, and hypertensive disorders during pregnancy, clarifying its genetic relationship with PE may improve our understanding of adverse pregnancy outcomes. Here, we investigated the shared genetic architecture between PE and waist\u2013hip ratio adjusted for body mass index (WHRadjBMI) by integrating large\u2010scale genome\u2010wide association study (GWAS) summary statistics for female WHRadjBMI from the GIANT consortium (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009\u2248\u2009700\u2009000) and PE from FinnGen R11 (7955 cases and 124\u2009764 controls). Analyses included genome\u2010wide genetic correlation, polygenic overlap, local genetic correlation, cross\u2010trait GWAS meta\u2010analysis, tissue\/cell type enrichment, functional annotation, and Mendelian randomization, using tools including linkage disequilibrium score regression (LDSC), MiXeR, LAVA, \u03c1\u2010HESS, MTAG, CPASSOC, and conjunctional false discovery rate (conjFDR). We identified approximately 0.5\u2009k shared causal variants; MiXeR detected a modest but significant polygenic overlap (rg\u2009=\u20090.08,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), whereas LDSC showed no significant genome\u2010wide correlation. A shared genetic locus near MTHFR\u2010CLCN6 (rs17367504) was detected, consistent with known PE biology. Enrichment analyses implicated VEGFA\u2010driven vascular and immune processes, with uterine pericytes displaying the strongest shared cell\u2010type enrichment. Mendelian randomization supported a causal effect of WHRadjBMI on PE (IVW:\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20092.7\u2009\u00d7\u200910\n                    <jats:sup>\u22124<\/jats:sup>\n                    ) but not reverse causation. These findings suggest that genetically predicted fat distribution may contribute to PE susceptibility and highlight shared vascular\u2013immune pathways that may link WHR\u2010related genetic risk to pregnancy complications.\n                  <\/jats:p>","DOI":"10.1096\/fj.202601888r","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T11:09:45Z","timestamp":1782212985000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic Correlation and Causal Inference Between Female Fat Distribution and Preeclampsia: An Integrative Genomic Study"],"prefix":"10.1096","volume":"40","author":[{"given":"Man","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Outpatient, Hubei Provincial Clinical Research Center for Umbilical Cord Blood Hematopoietic Stem Cells Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danfeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of General Surgery Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fengmei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"},{"name":"Department of Obstetrics and Gynecology The First Affiliated Hospital of Xi'an Jiaotong University  Xi'an Shanxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of General Surgery Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7485-8435","authenticated-orcid":false,"given":"Bo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"},{"name":"Brain Research Institute, Research Center of Neurological Diseases Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"},{"name":"Department of Assessment Office Taihe Hospital, Hubei University of Medicine  Shiyan Hubei China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,6,23]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581\u2010019\u20100119\u20106"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.siny.2020.101123"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.20945\/2359\u20103997000000605"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1753"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3238\/arztebl.2020.0659a"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000011639"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2023.19205"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/hr.2014.133"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12884\u2010024\u201006788\u20102"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2018.11.043"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu12051305"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2015.05.040"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy271"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010022\u201002238\u2010y"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature24277"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl4896"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adm7506"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3406"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbaa442"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001017\u2010y"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.11.011"},{"key":"e_1_2_11_23_1","first-page":"455","volume-title":"Methods in Molecular Biology","author":"Li X.","year":"2017"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2023.104647"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddu328"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10654\u2010015\u20100011\u2010z"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyr036"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010018\u20100099\u20107"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916\u2010023\u201002780\u20103"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004219"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010022\u201001187\u20109"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010024\u201001771\u20101"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059\u2010020\u201002026\u2010y"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3506"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1003679"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003\u2010025\u201007726\u20104"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00564\u201019"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/cob.12607"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1526-968X(200004)26:4<271::AID-GENE90>3.0.CO;2-E"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14010086"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000001131"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2014.10.004"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13124562"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13171510"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580\u2010023\u201000631\u2010w"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.9b00771"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fsi.2022.05.031"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202401343RRR"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/humu.23351"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.4239\/wjd.v5.i4.420"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/cphy.c170040"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202601888R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202601888R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202601888R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T16:23:23Z","timestamp":1782318203000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202601888R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,23]]},"references-count":50,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2026,6,30]]}},"alternative-id":["10.1096\/fj.202601888R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202601888r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,6,23]]},"assertion":[{"value":"2026-04-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72074"}}