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In the present study, we reported that taurine (TAU), a sulfur\u2010containing amino acid that exhibits antioxidant properties, protected the maturation quality of ZEN\u2010exposed porcine oocytes. We showed that TAU significantly reversed the cumulus cell expansion and polar body extrusion defects of porcine oocytes under ZEN treatment. The rescue effect of TAU was attributed to its regulation of mitochondrial functions, which recovered mitochondrial membrane potential (MMP), mitochondrial quantity and mitochondrial fission. This further balanced reactive oxygen species (ROS) levels and reduced early apoptosis and DNA damage of porcine oocytes. The protection of TAU was confirmed by the integrity of subcellular cytoskeleton dynamics of oocytes, since microtubule stability\u2010related spindle morphology and actin nucleation\u2010related actin assembly were all preserved upon TAU supplementation. Furthermore, we showed that TAU reduced GRP78\u2010dependent ER stress and autophagy levels and protected Rab10\u2010mediated vesicular transport, which further ensured the organelle distribution, such as ER, lysosomes, and Golgi apparatus. In conclusion, our study demonstrated that TAU effectively alleviated ZEN\u2010induced impairment of porcine oocyte developmental competence.<\/jats:p>","DOI":"10.1096\/fj.202601897r","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T06:00:11Z","timestamp":1782194411000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Protective Effects of Taurine Against Zearalenone\u2010Induced Quality Impairment During Porcine Oocyte Maturation"],"prefix":"10.1096","volume":"40","author":[{"given":"Yi\u2010Nuo","family":"Wei","sequence":"first","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing\u2010Ye","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agricultural University  Nanjing 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