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This study conducted a genome\u2010wide ASE analysis in embryonic (brain, kidney, liver) and extraembryonic (chorion) tissues of Landrace\u2009\u00d7\u2009Meishan crossbred pigs. By integrating DNA sequencing of parental and F1 hybrids and RNA\u2010sequencing of F1 tissues, a high\u2010resolution ASE landscape was built via strict allele\u2010specific SNP identification. Genomically, ASE genes (ASEG) were enriched on chromosomes 6, 7, 12, X and sparse on chromosome 11, and can be classified into extreme\/moderate types by expression pattern and parental bias. Paternal ASEGs had higher expression levels, while maternal ones had higher abundance. Functionally, tissue\u2010concordant ASEGs supported embryo\/placenta basal development, tissue\u2010specific ones matched organ core functions; maternal ASEGs were enriched in mitochondrial pathways, paternal ones in cell motility and RNA transcription. Besides, chorion had more allele\u2010specific methylated regions than embryonic tissues, with opposite ASE directions. We proposed \u201corthogonal dual regulatory dimensions\u201d for the relationship between ASE and tissue\u2010specific expression. We also proposed regulatory models of extreme and moderate ASEGs, functional division modes between embryo and extraembryonic tissues, and between paternal and maternal alleles. This study clarifies tissue\u2010specific ASE patterns and mechanisms, providing a framework for future ASE research.<\/jats:p>","DOI":"10.1096\/fj.202602058r","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T17:07:46Z","timestamp":1782925666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dissecting Allele\u2010Specific Expression (\n                    <scp>ASE<\/scp>\n                    ) in Landrace\u2009\u00d7\u2009Meishan Cross Pig Fetal\u2010Placental Tissues: Distribution, Functional Split, and Mechanisms"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3425","authenticated-orcid":false,"given":"Jinbi","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Animal Science and Food Engineering Jinling Institute of Technology  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyong","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Food Engineering Jinling Institute of Technology  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3775-2663","authenticated-orcid":false,"given":"Wangjun","family":"Wu","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agriculture University  Nanjing P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8166-9173","authenticated-orcid":false,"given":"Lifan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agriculture University  Nanjing P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zengxiang","family":"Pan","sequence":"additional","affiliation":[{"name":"College of Animal Science and Technology Nanjing Agriculture University  Nanjing P. R. 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