{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T15:01:45Z","timestamp":1784818905568,"version":"3.55.0"},"reference-count":83,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T00:00:00Z","timestamp":1782950400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,7,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Brain\u2010derived neurotrophic factor (BDNF) is a key member of the neurotrophin family that promotes neuronal function via its receptor kinase TrkB. However, recent work has demonstrated BDNF as a multifaceted regulator beyond its classic roles in the nervous system, particularly in renal patho\u2010physiology. This review summarizes the recent advances about BDNF\/TrkB signaling pathway in various kidney diseases, including chronic kidney disease (CKD) and acute kidney injury (AKI). Upon binding TrkB, BDNF initiates specific intracellular signaling pathways, such as PI3K\u2013Akt, MAPK\u2013ERK, and PLC\u03b3, to support cell survival, mitochondrial function, cytoskeletal integrity, and anti\u2010inflammatory responses. As such, the BDNF\u2013TrkB pathway represents a potential target for renal protection and regeneration, warranting further mechanistic and clinical investigation.<\/jats:p>","DOI":"10.1096\/fj.202602096r","type":"journal-article","created":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T06:47:20Z","timestamp":1783061240000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Brain\u2010Derived Neurotrophic Factor and Associated Signaling in Kidney Diseases"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4132-9406","authenticated-orcid":false,"given":"Cheng","family":"Xue","sequence":"first","affiliation":[{"name":"Department of Nephrology Shanghai Changzheng Hospital  Shanghai China"},{"name":"Department of Cellular Biology and Anatomy Medical College of Georgia at Augusta University  Augusta 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