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However, the intricate mechanism underlying the exosomal miRNAs from CAFs in gastric cancer (GC) tumorigenesis remains ambiguous. Herein, we found that miR\u20104435 was highly expressed in both CAFs\u2010 derived exos and GC tissues and was associated with TNM stage as well as tumor size in GC patients. Additionally, inhibition of miR\u20104435 remarkably restricted GC proliferation, migration, and invasion in\u00a0vitro and in\u00a0vivo; whereas facilitating ferroptosis in GC cells. Moreover, miR\u20104435 could bind with the downstream target NDUFA10 mRNA and was shown to silence NDUFA10 expression. Importantly, exosomal miR\u20104435 derived from CAFs could suppress CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells effector function, contributing to immune resistance, while knockdown of miR\u20104435 in CAFs\u2010exo could foster CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells effector function and enhanced the sensitivity of anti\u2010PD\u20101 therapy in GC. Collectively, exosomal miR\u20104435 derived from CAFs suppress ferroptosis and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell effector function in GC via mediating NDUFA10. Our results highlight exos\u2010transfered miR\u20104435 as a potential therapeutic target in GC.\n                  <\/jats:p>","DOI":"10.1096\/fj.202602170r","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T08:19:51Z","timestamp":1789805991000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Exosomes From Cancer\u2010Associated Fibroblasts Suppress Ferroptosis and\n                    <scp>CD8<\/scp>\n                    <sup>+<\/sup>\n                    T Cell Effector Function in Gastric Cancer via\n                    <scp>miR<\/scp>\n                    \u20104435\/\n                    <scp>NDUFA10<\/scp>\n                    Axis"],"prefix":"10.1096","volume":"40","author":[{"given":"Yingying","family":"Wang","sequence":"first","affiliation":[{"name":"The Third Department of Surgery The Fourth Hospital of Hebei Medical University  Shijiazhuang 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