{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T01:27:12Z","timestamp":1793582832205,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T00:00:00Z","timestamp":1788825600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,9,15]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Antipsychotic (AP) medications, such as olanzapine, cause acute weight gain independent of hyperglycemia through a glucagon\u2010dependent mechanism. Previous work has shown that exercise, a ketogenic diet, and fasting can protect against acute AP\u2010induced hyperglycemia and attenuate increases in glucagon. As these interventions all increase circulating concentrations of fibroblast growth factor 21 (FGF21), we hypothesized that increasing endogenous FGF21 through treatment with fenofibrate would protect against AP\u2010induced hyperglycemia. Male C57BL\/6J mice were fed a low\u2010fat diet with or without fenofibrate (0.2% w\/w) for 1\u2009week prior to an acute olanzapine (OLZ) challenge. Fenofibrate reduced food intake and caused weight loss while protecting against OLZ\u2010induced increases in serum glucagon and blood glucose. Pair feeding mice with the same amount of food as fenofibrate\u2010treated animals conferred a similar degree of protection against OLZ\u2010induced hyperglycemia. Furthermore, an acute oral gavage with fenofibrate, despite increasing circulating FGF21 concentrations to a similar level as fenofibrate feeding, failed to protect against OLZ\u2010induced glucose excursions. The effects of fenofibrate on weight loss and protection against OLZ\u2010induced hyperglycemia were attenuated in\n                    <jats:italic>FGF21<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice. Fenofibrate attenuated both OLZ\u2010induced hyperlipidemia and increases in whole\u2010body fatty acid oxidation, with the latter effects being dependent upon FGF21. Together, our findings demonstrate that fenofibrate protects against acute olanzapine\u2010induced hyperglycemia and hyperlipidemia in a weight loss and FGF21\u2010dependent manner.\n                  <\/jats:p>","DOI":"10.1096\/fj.202602558r","type":"journal-article","created":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T14:26:12Z","timestamp":1788877572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fenofibrate Protects Against Antipsychotic\u2010Induced Hyperglycemia Through Weight Loss and FGF21 Dependent Mechanisms"],"prefix":"10.1096","volume":"40","author":[{"given":"Michael","family":"Akcan","sequence":"first","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stewart","family":"Jeromson","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J.","family":"Baranowski","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalaura","family":"Bellucci","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Trang","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katelyn","family":"Eisner","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ailish","family":"Babicki\u2010Moore","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hadil","family":"Alfares","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meagan","family":"Arbeau","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle","family":"Medak","sequence":"additional","affiliation":[{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Hahn","sequence":"additional","affiliation":[{"name":"Schizophrenia Division Centre for Addiction and Mental Health  Toronto Ontario Canada"},{"name":"Institute of Medical Science University of Toronto  Toronto Ontario Canada"},{"name":"Department of Psychiatry University of Toronto  Toronto Ontario Canada"},{"name":"Banting &amp; Best Diabetes Centre University of Toronto  Toronto Ontario Canada"},{"name":"Department of Pharmacology &amp; Toxicology University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3867-8901","authenticated-orcid":false,"given":"David C.","family":"Wright","sequence":"additional","affiliation":[{"name":"School of Kinesiology University of British Columbia  Vancouver British Columbia Canada"},{"name":"BC Children's Hospital Research Institute  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,8]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.9778\/cmajo.20140009"},{"key":"e_1_2_10_3_1","unstructured":"A. R.Maher M.Maglione S.Bagley et\u00a0al. \u201cEfficacy and Comparative Effectiveness of Atypical Antipsychotic Medications for Off\u2010Label Uses in Adults \u201d."},{"key":"e_1_2_10_4_1","unstructured":"\u201cPersistent Antipsychotic Polypharmacy and Excessive Dosing in the Community Psychiatric Treatment Setting: A Review of Medication Profiles in 435 Canadian Outpatients \u201dPsychiatrist.com."},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0284389"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2009.01.005"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2011.156"},{"key":"e_1_2_10_8_1","article-title":"Preclinical and Clinical Sex Differences in Antipsychotic\u2010Induced Metabolic Disturbances: A Narrative Review of Adiposity and Glucose Metabolism","volume":"4","author":"Castellani L. N.","year":"2019","journal-title":"Journal of Psychiatry and Brain Science"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4324-8"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2555-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022662"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/JCP.0b013e31829e8333"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.2.284"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2019.104413"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201901820R"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-19260-x"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.118.248393"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00876.2020"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.08.006"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.12148"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbs196"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-0063"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.290.4.486"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050719"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105257"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.12.012"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.05.005"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.108628"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00309.2020"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282922"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-1815"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.2337\/db13-0430"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP282922"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/jhn.12473"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.2018.167"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/wps.20318"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2007.05.002"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP283469"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-019-02124-3"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0063517"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0167-4781(00)00067-1"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-physiol-021115-105339"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2008.03502.x"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-020-0386-0"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0701600104"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0221"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI23606"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00348.2009"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2021.05.016"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19072148"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M116.767590"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904187106"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2017.12.004"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1949.sp004363"},{"key":"e_1_2_10_55_1","first-page":"3","article-title":"Atypical Antipsychotics: Sleep, Sedation, and Efficacy","volume":"6","author":"Miller D. D.","year":"2004","journal-title":"Prim Care Companion J Clin Psychiatry"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.102.046987"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2018.06.019"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.4161\/cbt.8.16.9006"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.3904\/kjim.2016.233"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-1471"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2009.12.013"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2009.09.012"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2009-0119"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(02)00822-7"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.52.9.2249"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.26203"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1177\/147323001103900531"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.06.016"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2020.103130"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202602558R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202602558R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202602558R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T00:51:03Z","timestamp":1793580663000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202602558R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,8]]},"references-count":68,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2026,9,15]]}},"alternative-id":["10.1096\/fj.202602558R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202602558r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,8]]},"assertion":[{"value":"2026-05-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72285"}}