{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T07:45:21Z","timestamp":1791791121856,"version":"4.3.4"},"reference-count":54,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T00:00:00Z","timestamp":1790121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473535"],"award-info":[{"award-number":["82473535"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006407","name":"Natural Science Foundation of Henan Province","doi-asserted-by":"publisher","award":["262300422341"],"award-info":[{"award-number":["262300422341"]}],"id":[{"id":"10.13039\/501100006407","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,9,30]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lupus nephritis (LN) is a critical complication of systemic lupus erythematosus (SLE) and a leading cause of mortality in those affected. Abnormal energy metabolism of macrophages is closely associated with LN pathogenesis. Adenosine diphosphate (ADP) is known to regulate macrophage proinflammatory function; however, its specific role in SLE progression remains unexplored. We employed a spontaneous SLE mouse model and an integrated transcriptomic and metabolomic approach to investigate the effect of ADP on SLE disease progression and macrophage function. Our study revealed that ADP stimulates the AMPK signaling pathway, curtails macrophage senescence, and diminishes the release of senescence\u2010associated secretory phenotype factors, ultimately alleviating SLE progression. Mechanistically, ADP promotes KLF10 expression, which binds to Sirtuin1 to facilitate deacetylation at the promoter region of\n                    <jats:italic>Cdkn1a<\/jats:italic>\n                    in macrophages. This process leads to reduced p21 expression and macrophage senescence. Collectively, the findings uncover a novel regulatory role of ADP in the pathogenesis of SLE and macrophage senescence, indicating its potential as a target for treatment.\n                  <\/jats:p>","DOI":"10.1096\/fj.202603249r","type":"journal-article","created":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:02:49Z","timestamp":1790172169000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["<scp>ADP<\/scp>\n                    Inhibits Macrophage Senescence via the\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>KLF10<\/scp>\n                    Pathway in Systemic Lupus Erythematosus"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4527-4685","authenticated-orcid":false,"given":"Shuang","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuli","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanteng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuya","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinlin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion Fuwai Central China Cardiovascular Hospital  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiankun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Blood Transfusion The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junhu","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou University  Zhengzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing China"},{"name":"Key Laboratory of Basic and Translational Research on Immune\u2010Mediated Skin Diseases Chinese Academy of Medical Sciences  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,23]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2010.06.011"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2019-215089"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2016.03.042"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keaa381"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.kint.2017.09.033"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2017.43"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112149"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2017.11.003"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo9110248"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.165546"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2012.69"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201009094"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-00314-w"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2018121251"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.656090"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00309.2015"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2017.95"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcancer.2024.08.002"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-869518"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1800352"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.621963"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2018.07.013"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1136\/lupus-2020-000436"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.10.032"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2017.10.009"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3311"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(87)80292-2"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18014"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0350-5"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1191241"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1403088"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.04.013"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0002599"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.2242"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7601378"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2026.121903"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12075"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.03.018"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.5483\/BMBRep.2015.48.10.122"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2018"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2022.11.001"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathol-121808-102144"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-022-00601-z"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.909353"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2021-001844"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-00539-x"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201242697"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2026.111048"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00345-9"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e29848"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.112743"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05734-5"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.70065"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-04-496216"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202603249R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202603249R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202603249R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T06:52:45Z","timestamp":1791787965000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202603249R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,23]]},"references-count":54,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2026,9,30]]}},"alternative-id":["10.1096\/fj.202603249R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202603249r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,23]]},"assertion":[{"value":"2026-06-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72297"}}