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Here, we reconstructed stage\u2010specific ligand\u2013receptor communication networks through a transcriptomic meta\u2010analysis integrating bovine secondary, early antral, and middle antral follicles. Our analyses revealed that oocyte\u2013granulosa cell communication undergoes progressive remodeling during folliculogenesis, with distinct signaling programs characterizing successive developmental stages. Secondary follicles were predominantly associated with extracellular matrix organization, cell adhesion, and early metabolic regulation. During the early antral stage, signaling shifted toward lipid, steroid, and vitamin metabolism, identifying this phase as a major metabolic transition. Middle antral follicles exhibited a marked increase in communication complexity, with enrichment of PI3K\u2013AKT, mTOR, RAS, Hippo, and cell adhesion pathways accompanying the acquisition of developmental competence. Additional analyses of Brilliant Cresyl Blue\u2010classified cumulus\u2013oocyte complexes identified competence\u2010associated ligand\u2010receptor interactions, while independent validation using the EmbryoGENE dataset confirmed stage\u2010specific expression patterns and highlighted\n                    <jats:italic>CD47<\/jats:italic>\n                    ,\n                    <jats:italic>FGF21<\/jats:italic>\n                    , and\n                    <jats:italic>GPC6<\/jats:italic>\n                    as candidate regulators of oocyte developmental competence. This study provides a comprehensive transcriptomic framework describing the dynamic remodeling of oocyte\u2013granulosa cell communication during bovine folliculogenesis. Beyond confirming established signaling pathways, it identifies novel candidate interactions and offers a biologically grounded resource to guide future functional studies and the optimization of in\u00a0vitro follicle and cumulus\u2013oocyte complex culture systems.\n                  <\/jats:p>","DOI":"10.1096\/fj.202603316rr","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:26:25Z","timestamp":1789133185000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Dynamic Remodeling of Oocyte\u2010Granulosa Cell Communication During Bovine Folliculogenesis Revealed by Transcriptomic Meta\u2010Analyses"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2339-9953","authenticated-orcid":false,"given":"Noemi","family":"Monferini","sequence":"first","affiliation":[{"name":"Reproductive and Developmental Biology Laboratory (ReDBioLab), Department of 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