{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:34:22Z","timestamp":1793255662493,"version":"4.5.0"},"reference-count":68,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T00:00:00Z","timestamp":1791849600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["404204\/2023\u20106"],"award-info":[{"award-number":["404204\/2023\u20106"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["305332\/2024\u20104"],"award-info":[{"award-number":["305332\/2024\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/204.202\/2025"],"award-info":[{"award-number":["E\u201026\/204.202\/2025"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","award":["E\u201026\/210.552\/2026"],"award-info":[{"award-number":["E\u201026\/210.552\/2026"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2026,10,31]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Tryptophan (TRP) is primarily metabolized via the kynurenine (KYN) pathway, which plays a central role in energy homeostasis, as well as immune, inflammatory, and neurobiological regulation. Although a single exercise session may modulate this pathway, the magnitude and consistency of these responses remain unclear. Therefore, this meta\u2010analysis aimed to synthesize acute exercise\u2013induced changes in KYN pathway metabolites. PubMed, Web of Science, and Scopus were searched from inception to June 2026. Clinical trials evaluating the effects of a single exercise session on circulating TRP and KYN pathway metabolites were included. Random\u2010effects meta\u2010analyses were performed using standardized mean differences (Hedges' g). Outcomes were analyzed separately for immediate post\u2010exercise responses (\u2264\u20095\u2009min) and recovery responses (&gt;\u20095\u2009min to 3\u2009h). Prespecified subgroup analyses examined population characteristics, training status, and exercise modality. Of 3203 records, 24 clinical trials (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009695) were included in the systematic review, and 20 provided data for meta\u2010analysis. Immediately after exercise, TRP decreased, whereas KYN, KYN\/TRP, kynurenic acid (KYNA), and quinolinic acid (QA) increased. During recovery, reductions in TRP and elevations in KYN\/TRP persisted, whereas KYN and QA returned toward baseline. KYNA remained elevated, while QA\/KYNA remained unchanged. Subgroup analyses suggested larger responses in healthy individuals, trained participants, and following aerobic exercise, particularly for TRP and KYNA. Exercise induces heterogeneous changes in KYN metabolism, characterized by reduced TRP and increased KYN\/TRP ratio and downstream metabolites. These responses are transient and context\u2010dependent, reflecting acute changes in metabolic flux rather than sustained pathway remodeling.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    PROSPERO, identifier CRD42022351481\n                  <\/jats:p>","DOI":"10.1096\/fj.202603422r","type":"journal-article","created":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T14:26:29Z","timestamp":1791901589000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Single Exercise Session Elicits a Transient Kynurenine Metabolic Signature in Health and Disease: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1096","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7663-0875","authenticated-orcid":false,"given":"Marcus Vinicius dos Santos","family":"Rangel","sequence":"first","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports University of Rio de Janeiro State  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8226-3813","authenticated-orcid":false,"given":"Gabriela Andrade","family":"Paz","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports University of Rio de Janeiro State  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5512-2871","authenticated-orcid":false,"given":"Maria das Gra\u00e7as C.","family":"Souza","sequence":"additional","affiliation":[{"name":"Clinical and Experimental Research Laboratory on Vascular Biology (BioVasc) University of Rio de Janeiro State  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1816-8595","authenticated-orcid":false,"given":"Marie","family":"Kupjetz","sequence":"additional","affiliation":[{"name":"Research Group \u201cSports Medicine\u201d, Institute for Sport and Sport Science TU Dortmund University  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany Y.","family":"Wences Chirino","sequence":"additional","affiliation":[{"name":"Research Group \u201cSports Medicine\u201d, Institute for Sport and Sport Science TU Dortmund University  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9631-4503","authenticated-orcid":false,"given":"Philipp","family":"Zimmer","sequence":"additional","affiliation":[{"name":"Research Group \u201cSports Medicine\u201d, Institute for Sport and Sport Science TU Dortmund University  Dortmund Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2463-1280","authenticated-orcid":false,"given":"Paulo","family":"Farinatti","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports University of Rio de Janeiro State  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3581-7251","authenticated-orcid":false,"given":"Juliana Pereira","family":"Borges","sequence":"additional","affiliation":[{"name":"Laboratory of Physical Activity and Health Promotion, Institute of Physical Education and Sports University of Rio de Janeiro State  Rio de Janeiro Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.acc.2019.08.005"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.06.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.5482\/HAMO-14-10-0052"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0000000000002664"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25020853"},{"key":"e_1_2_11_7_1","first-page":"68","article-title":"The Neurochemistry of Depression: The Good, the Bad and the Ugly","volume":"121","author":"Pearson K.","year":"2024","journal-title":"Missouri Medicine"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/D3CP06036E"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110841"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-2882"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/104024"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.13768"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-024-01496-z"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2020.11.006"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2022.0916"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fspor.2025.1535152"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000003488"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00580.2019"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2018.07.015"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-020-04375-9"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-024-01878-5"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10712-0"},{"key":"e_1_2_11_23_1","first-page":"83","volume-title":"Hormones, Metabolism and the Benefits of Exercise","author":"Valente\u2010Silva P.","year":"2018"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41574-019-0174-x"},{"key":"e_1_2_11_25_1","first-page":"24","article-title":"Exercise and the Kynurenine Pathway: Current State of Knowledge and Results From a Randomized Cross\u2010Over Study Comparing Acute Effects of Endurance and Resistance Training","volume":"26","author":"Joisten N.","year":"2020","journal-title":"Exercise Immunology Review"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1515\/pteridines-2019-0003"},{"key":"e_1_2_11_27_1","first-page":"669","article-title":"Do Acute Exercise\u2010Induced Activations of the Kynurenine Pathway Induce Regulatory T\u2010Cells on the Long\u2010Term?\u2014A Theoretical Frame Work Supported by Pilot Data","volume":"18","author":"Koliamitra C.","year":"2019","journal-title":"Journal of Sports Science and Medicine"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0338814"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001006"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu14214485"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00053.2016"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153617"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2021.105433"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00285.2021"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.2798"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biochi.2025.11.004"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms27010129"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/XEB.0000000000000020"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4919"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1037\/1082-989X.11.2.193"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8110752"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-81306-4"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00282.2024"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1177\/1178646920978241"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1519\/JSC.0000000000003958"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70123"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2017.12.001"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.3233\/NRE-192773"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11010004"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000000982"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbih.2025.101030"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1732461"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.3389\/fragi.2026.1832962"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00080.2007"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2012.49"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa016"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202301619R"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.07.051"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf9794"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01957"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2024.11.004"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70125"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2020.110831"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202500295R"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1080\/19490976.2024.2409209"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03645-1"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.70166"}],"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202603422R","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/full-xml\/10.1096\/fj.202603422R","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fj.202603422R","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T05:50:26Z","timestamp":1793253026000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fj.202603422R"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,13]]},"references-count":68,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10,31]]}},"alternative-id":["10.1096\/fj.202603422R"],"URL":"https:\/\/doi.org\/10.1096\/fj.202603422r","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,13]]},"assertion":[{"value":"2026-07-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-13","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e72349"}}