{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:29:32Z","timestamp":1770488972446,"version":"3.49.0"},"reference-count":0,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[1997,7,1]],"date-time":"1997-07-01T00:00:00Z","timestamp":867715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1997,7]]},"abstract":"<jats:p>\n                    Protein kinase C (PKC) is a phospholipid\u2010dependent serine\/threonine kinase family consisting of at least 11 closely related isoenzymes. The different PKC isoenzymes play important roles in signal transduction pathways. The exact significance of each isoenzyme is not known at present; therefore, the elucidation of the roles of the various PKC isoenzymes is important. To explain the function of distinct PKC isoenzymes, the availability of isoenzyme\u2010specific inhibibitors or activators would be an advantage. PKC inhibitors have been known for some time, but these compounds are not isoenzyme\u2010specific and also inhibit other kinases. Recently, an inhibitor selective for PKC\u03b1 and another one selective for PKC\u03b2I and \u03b2II were described. Both compounds compete with the ATP binding sites that exhibit high homologies among the different PKC isoenzymes. Among others, the phosporyl transfer region, the pseudosubstrate domain, the phorbolester binding sequences, and the phosphorylation sites may also be targets for modulation of isoenzyme\u2010specific PKC activity. The question is whether the differences in these domains and the substrate specificity of the PKC isoenzymes will allow isoenzyme\u2010specific inhibition. In this review the human sequences of these sites, isoenzyme\u2010specific substrates, inhibitory compounds, and inhibitory peptides are summarized.\u2014Hofmann, J. The potential for isoenzyme\u2010selective modulation of protein kinase C.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    11, 649\u2013669 (1997)\n                  <\/jats:p>","DOI":"10.1096\/fasebj.11.8.9240967","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T07:04:24Z","timestamp":1516259064000},"page":"649-669","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":279,"title":["The potential for isoenzyme\u2010selective modulation of protein kinase C"],"prefix":"10.1096","volume":"11","author":[{"given":"Johann","family":"Hofmann","sequence":"first","affiliation":[{"name":"Institute of Medical Chemistry and Biochemistry University of Innsbruck A\u20106020 Innsbruck Austria"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1997,7]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.11.8.9240967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.11.8.9240967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:05:35Z","timestamp":1761674735000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.11.8.9240967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1997,7]]},"references-count":0,"journal-issue":{"issue":"8","published-print":{"date-parts":[[1997,7]]}},"alternative-id":["10.1096\/fasebj.11.8.9240967"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.11.8.9240967","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1997,7]]},"assertion":[{"value":"1997-07-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}