{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T14:28:43Z","timestamp":1773152923328,"version":"3.50.1"},"reference-count":0,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[1991,6,1]],"date-time":"1991-06-01T00:00:00Z","timestamp":675734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[1991,6]]},"abstract":"<jats:p>\n                    The nuclear hormone receptor superfamily is characterized by an impressive functional diversity of its members despite a remarkable overall structural unity. A variety of ligands bind specifically to them and these receptors control gene networks that have profound effects on growth, development, and homeostasis. The ligand\u2010receptor complexes recognize transcriptional enhancer DNA sequences, the hormone response elements, resulting in induction or repression of gene activity. The similarity between all these hormone response enhancer elements, as well as between the receptors themselves, indicates a conserved general strategy for the hormonal control of transcription by steroids. The activated receptors bind to responsive promoters and most likely mediate the assembly of stage\u2010 and tissue\u2010specific transcription factor complexes that stimulate or inhibit gene expression.\u2014Wahli, W.; Martinez, E. Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression.\n                    <jats:italic>FASEB J.<\/jats:italic>\n                    5: 2243\u20132249; 1991.\n                  <\/jats:p>","DOI":"10.1096\/fasebj.5.9.1860615","type":"journal-article","created":{"date-parts":[[2018,1,18]],"date-time":"2018-01-18T08:43:08Z","timestamp":1516264988000},"page":"2243-2249","source":"Crossref","is-referenced-by-count":204,"title":["Superfamily of steroid nuclear receptors: positive and negative regulators of gene expression"],"prefix":"10.1096","volume":"5","author":[{"given":"Walter","family":"Wahli","sequence":"first","affiliation":[{"name":"Institut de Biologie Animate Universit\u00e9 de Lausanne, B\u00e2timent de Biologie CH\u20101015 Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ernest","family":"Martinez","sequence":"additional","affiliation":[{"name":"Institut de Biologie Animate Universit\u00e9 de Lausanne, B\u00e2timent de Biologie CH\u20101015 Lausanne Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[1991,6]]},"container-title":["The FASEB Journal"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.5.9.1860615","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/pdf\/10.1096\/fasebj.5.9.1860615","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T19:28:58Z","timestamp":1761679738000},"score":1,"resource":{"primary":{"URL":"https:\/\/faseb.onlinelibrary.wiley.com\/doi\/10.1096\/fasebj.5.9.1860615"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,6]]},"references-count":0,"journal-issue":{"issue":"9","published-print":{"date-parts":[[1991,6]]}},"alternative-id":["10.1096\/fasebj.5.9.1860615"],"URL":"https:\/\/doi.org\/10.1096\/fasebj.5.9.1860615","archive":["Portico"],"relation":{},"ISSN":["0892-6638","1530-6860"],"issn-type":[{"value":"0892-6638","type":"print"},{"value":"1530-6860","type":"electronic"}],"subject":[],"published":{"date-parts":[[1991,6]]}}}