{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T06:07:58Z","timestamp":1768198078771,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T00:00:00Z","timestamp":1112572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["252823"],"award-info":[{"award-number":["252823"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["SCHR 752\/2\u20101"],"award-info":[{"award-number":["SCHR 752\/2\u20101"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Protease\u2010activated receptors (PARs) are widely distributed in human airways. They couple to G\u2010proteins and are activated after proteolytic cleavage of the N terminus of the receptor. Evidence is growing that PAR subtype 2 plays a pivotal role in inflammatory airway diseases, such as allergic asthma or bronchitis. However, nothing is known about the effects of PAR\u20102 on electrolyte transport in the native airways. PAR\u20102 is expressed in airway epithelial cells, where they are activated by mast cell tryptase, neutrophil proteinase 3, or trypsin. Recent studies produced conflicting results about the functional consequence of PAR\u20102 stimulation. Here we report that stimulation of PAR\u20102 receptors in mouse and human airways leads to a change in electrolyte transport and a shift from absorption to secretion. Although PAR\u20102 appears to be expressed on both sides of the epithelium, only basolateral stimulation results in inhibition of amiloride sensitive Na\n                    <jats:sup>+<\/jats:sup>\n                    conductance and stimulation of both luminal Cl\n                    <jats:sup>\u2010<\/jats:sup>\n                    channels and basolateral K\n                    <jats:sup>+<\/jats:sup>\n                    channels. The present data indicate that these changes occur through activation of phospholipase C and increase in intracellular Ca\n                    <jats:sup>2+<\/jats:sup>\n                    , which activates basolateral SK4 K\n                    <jats:sup>+<\/jats:sup>\n                    channels and luminal Ca\n                    <jats:sup>2+<\/jats:sup>\n                    \u2010dependent Cl\n                    <jats:sup>\u2010<\/jats:sup>\n                    channels. In addition, the present data suggest a PAR\u20102 mediated release of prostaglandin E2, which may contribute to the secretory response. In conclusion, these results provide further evidence for a role of PAR\u20102 in inflammatory airway disease: stimulation of these receptors may cause accumulation of airway surface liquid, which, however, may help to flush noxious stimuli away from the affected airways.\n                  <\/jats:p>","DOI":"10.1096\/fj.04-2469fje","type":"journal-article","created":{"date-parts":[[2005,4,4]],"date-time":"2005-04-04T20:31:32Z","timestamp":1112646692000},"page":"969-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Control of ion transport in mammalian airways by protease activated receptors type 2 (PAR\u20102)"],"prefix":"10.1096","volume":"19","author":[{"given":"Karl","family":"Kunzelmann","sequence":"first","affiliation":[{"name":"Institut f\u00fcr Physiologie Universit\u00e4t Regensburg Universit\u00e4tstra\u00dfe 31  D\u201093053 Regensburg Germany"}]},{"given":"Jane","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Department of Physiology &amp; Pharmacology University of Queensland  St. Lucia QLD 4072 Brisbane Australia"}]},{"given":"Daniel","family":"Markovich","sequence":"additional","affiliation":[{"name":"School of Biomedical Sciences Department of Physiology &amp; Pharmacology University of Queensland  St. Lucia QLD 4072 Brisbane Australia"}]},{"given":"Jens","family":"K\u00f6nig","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie Universit\u00e4t Regensburg Universit\u00e4tstra\u00dfe 31  D\u201093053 Regensburg Germany"}]},{"given":"Bettina","family":"M\u00fcrle","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie Universit\u00e4t Regensburg Universit\u00e4tstra\u00dfe 31  D\u201093053 Regensburg Germany"}]},{"given":"Marcus","family":"Mall","sequence":"additional","affiliation":[{"name":"Mukoviszidose \u2014 Zentrum Universit\u00e4ts\u2010Kinderklinik III  Heidelberg Germany"}]},{"given":"Rainer","family":"Schreiber","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologie Universit\u00e4t Regensburg Universit\u00e4tstra\u00dfe 31  D\u201093053 Regensburg Germany"}]}],"member":"311","published-online":{"date-parts":[[2005,4,4]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0031-6997(24)01493-5","article-title":"Proteinase\u2010activated receptors","volume":"53","author":"Macfarlane S. 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