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Intrarenal dopamine plays an important role in the pathogenesis of hypertension by regulating epithelial sodium transport. The candidate transport systems for L\u2010DOPA, the source for dopamine, include the sodium\u2010dependent systems B\n                    <jats:sup>0<\/jats:sup>\n                    , B\n                    <jats:sup>0,+<\/jats:sup>\n                    , and y\n                    <jats:sup>+<\/jats:sup>\n                    L, and the sodium\u2010independent systems L (LAT1 and LAT2) and b\n                    <jats:sup>0+<\/jats:sup>\n                    . Renal LAT2 is overexpressed in the prehypertensive spontaneously hypertensive rat (SHR), which might contribute to enhanced L\u2010DOPA uptake in the proximal tubule and increased dopamine production, as an attempt to overcome the defect in D\n                    <jats:sub>1<\/jats:sub>\n                    receptor function. On the other hand, it has been recently reported that impaired arginine transport contributes to low renal nitric oxide bioavailability observed in the SHR renal medulla. Here we review the importance of renal amino acid transporters in the kidney and highlight pathophysiological changes in the expression and regulation of these transporters in essential hypertension. The study of the regulation of renal amino acid transporters may help to define the underlying mechanisms predisposing individuals to an increased risk for development of hypertension.\u2014Pinto, V., Pinho, M. J., Soares\u2010da\u2010Silva, P., Renal amino acid transport systems and essential hypertension. FASEB J. 27, 2927\u20132938 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.12-224998","type":"journal-article","created":{"date-parts":[[2013,4,25]],"date-time":"2013-04-25T00:12:36Z","timestamp":1366848756000},"page":"2927-2938","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Renal amino acid transport systems and essential hypertension"],"prefix":"10.1096","volume":"27","author":[{"given":"Vanda","family":"Pinto","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Therapeutics Faculty of Medicine University of Porto Porto Portugal"},{"name":"Institute for Molecular and Cell Biology (IBMC) University of Porto Porto Portugal"}]},{"given":"Maria Jo\u00e3o","family":"Pinho","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics Faculty of Medicine University of Porto Porto Portugal"}]},{"given":"Patr\u00edcio","family":"Soares\u2010da\u2010Silva","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Therapeutics Faculty of Medicine University of Porto Porto Portugal"}]}],"member":"311","published-online":{"date-parts":[[2013,4,24]]},"reference":[{"key":"e_1_2_19_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)17741-1"},{"key":"e_1_2_19_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.289.19.2560"},{"key":"e_1_2_19_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pop.2008.06.001"},{"key":"e_1_2_19_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199005313222203"},{"key":"e_1_2_19_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2006.05.017"},{"key":"e_1_2_19_7_1","first-page":"435","article-title":"Blood pressure changes produced by kidney cross\u2010transplantation between spontaneously hypertensive rats and normotensive rats","volume":"47","author":"Bianchi G.","year":"1974","journal-title":"Clin. 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