{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,5]],"date-time":"2026-04-05T10:21:50Z","timestamp":1775384510615,"version":"3.50.1"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2013,6,27]],"date-time":"2013-06-27T00:00:00Z","timestamp":1372291200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2013,10]]},"abstract":"<jats:p>\n                    In developed societies, high\u2010sugar and high\u2010fat (HSHF) diets are now the norm and are increasing the rates of maternal obesity during pregnancy. In pregnant rodents, these diets lead to cardiovascular and metabolic dysfunction in their adult offspring, but the intrauterine mechanisms involved remain unknown. This study shows that, relative to standard chow, HSHF feeding throughout mouse pregnancy increases maternal adiposity (+30%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05) and reduces fetoplacental growth at d 16 (\u201310%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001). At d 19, however, HSHF diet group pup weight had normalized, despite the HSHF diet group placenta remaining small and morphologically compromised. This altered fetal growth trajectory was associated with enhanced placental glucose and amino acid transfer (+35%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.001) and expression of their transporters (+40%,\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.024). HSHF feeding also up\u2010regulated placental expression of fatty acid transporter protein, metabolic signaling pathways (phosphoinositol 3\u2010kinase and mitogen\u2010activated protein kinase), and several growth regulatory imprinted genes (\n                    <jats:italic>Igf2, Dlk1, Snrpn, Grb10,<\/jats:italic>\n                    and\n                    <jats:italic>H19)<\/jats:italic>\n                    independently of changes in DNA methylation. Obesogenic diets during pregnancy, therefore, alter maternal nutrient partitioning, partly through changes in the placental phenotype, which helps to meet fetal nutrient demands for growth near term. However, by altering provision of specific nutrients, dietary\u2010induced placental adaptations have important roles in programming development with health implications for the offspring in later life.\u2014Sferruzzi\u2010Perri, A N., Vaughan, O. R., Haro, M., Cooper, W. N., Musial, B., Charalambous, M., Pestana, D., Ayyar, S., Ferguson\u2010Smith, A C., Burton, G. J., Con\u2010stancia, M., Fowden, A. L., An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory. FASEB J. 27, 3928\u20133937 (2013).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-234823","type":"journal-article","created":{"date-parts":[[2013,6,29]],"date-time":"2013-06-29T00:15:00Z","timestamp":1372464900000},"page":"3928-3937","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":127,"title":["An obesogenic diet during mouse pregnancy modifies maternal nutrient partitioning and the fetal growth trajectory"],"prefix":"10.1096","volume":"27","author":[{"given":"Amanda N.","family":"Sferruzzi\u2010Perri","sequence":"first","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Owen R.","family":"Vaughan","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Maria","family":"Haro","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre Cambridge UK"}]},{"given":"Wendy N.","family":"Cooper","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre Cambridge UK"}]},{"given":"Barbara","family":"Musial","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Marika","family":"Charalambous","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Diogo","family":"Pestana","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre Cambridge UK"}]},{"given":"Shruti","family":"Ayyar","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Anne C.","family":"Ferguson\u2010Smith","sequence":"additional","affiliation":[{"name":"Metabolic Research Laboratories Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre Cambridge UK"}]},{"given":"Graham J.","family":"Burton","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"}]},{"given":"Miguel","family":"Constancia","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge UK"},{"name":"Metabolic Research Laboratories Department of Obstetrics and Gynaecology and National Institute for Health Research Cambridge Biomedical Research Centre Cambridge UK"}]},{"given":"Abigail L.","family":"Fowden","sequence":"additional","affiliation":[{"name":"Centre for Trophoblast Research Department of Physiology, Development, and Neuroscience University of Cambridge Cambridge 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