{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:48:29Z","timestamp":1761698909718,"version":"build-2065373602"},"reference-count":37,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,2,5]],"date-time":"2014-02-05T00:00:00Z","timestamp":1391558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Hartstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003092","name":"Diabetes Fonds","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002997","name":"Nierstichting","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002997","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["faseb.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["The FASEB Journal"],"published-print":{"date-parts":[[2014,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fructose consumption has been associated with the surge in obesity and dyslipidemia. This may be mediated by the fructose effects on hepatic lipids and ATP levels. Fructose metabolism provides carbons for\n                    <jats:italic>de novo<\/jats:italic>\n                    lipogenesis (DNL) and stimulates enterocyte secretion of apoB48. Thus, fructose\u2010induced hepatic triglyceride (HTG) accumulation can be attributed to both DNL stimulation and dietary lipid absorption. The aim of this study was to assess the effects of fructose diet on HTG and ATP content and the contributions of dietary lipids and DNL to HTG. Measurements were performed\n                    <jats:italic>in vivo<\/jats:italic>\n                    in mice by magnetic resonance imaging (MRI) and novel magnetic resonance spectroscopy (MRS) approaches. Abdominal adipose tissue volume and intramyocellular lipid levels were comparable between 8\u2010wk fructose\u2010 and glucose\u2010fed mice. HTG levels were ~1.5\u2010fold higher in fructose\u2010fed than in glucose\u2010fed mice (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;0.05). Metabolic flux analysis by\n                    <jats:sup>13<\/jats:sup>\n                    C and\n                    <jats:sup>2<\/jats:sup>\n                    H MRS showed that this was not due to dietary lipid absorption, but due to DNL stimulation. The contribution of oral lipids to HTG was, after 5 h, 1.60 \u00b1 0.23% for fructose and 2.16 \u00b1 0.35% for glucose diets (\n                    <jats:italic>P<\/jats:italic>\n                    =0.26), whereas that of DNL was higher in fructose than in glucose diets (2.55\u00b10.51\n                    <jats:italic>vs<\/jats:italic>\n                    . 1.13\u00b10.24%,\n                    <jats:italic>P<\/jats:italic>\n                    =0.01). Hepatic energy status, assessed by P MRS, was similar for fructose\u2010 and glucose\u2010fed mice. Fructose\u2010induced HTG accumulation is better explained by DNL and not by dietary lipid uptake, while not compromising ATP homeostasis.\u2014Nunes, P. M., Wright, A. J., Veltien, A., van Asten, J. J. A., Tack, C. J., Jones, J. G., Heerschap, A. Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose\u2010 compared to glucose\u2010fed mice.\n                    <jats:italic>FASEB J<\/jats:italic>\n                    . 28, 1988\u20131997 (2014).\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.fasebj.org\">www.fasebj.org<\/jats:ext-link>\n                  <\/jats:p>","DOI":"10.1096\/fj.13-241208","type":"journal-article","created":{"date-parts":[[2014,2,6]],"date-time":"2014-02-06T02:29:13Z","timestamp":1391653753000},"page":"1988-1997","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Dietary lipids do not contribute to the higher hepatic triglyceride levels of fructose\u2010 compared to glucose\u2010fed mice"],"prefix":"10.1096","volume":"28","author":[{"given":"Patricia M.","family":"Nunes","sequence":"first","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]},{"given":"Alan J.","family":"Wright","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]},{"given":"Andor","family":"Veltien","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]},{"given":"Jack J. A.","family":"van Asten","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]},{"given":"Cees J.","family":"Tack","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]},{"given":"John G.","family":"Jones","sequence":"additional","affiliation":[{"name":"Centre for Neurosciences and Cell Biology University of Coimbra Coimbra Portugal"}]},{"given":"Arend","family":"Heerschap","sequence":"additional","affiliation":[{"name":"Department of Radiology Radboud University Nijmegen Medical Centre Nijmegen The Netherlands"}]}],"member":"311","published-online":{"date-parts":[[2014,2,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/193229681000400432"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI37385"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114508968252"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2008-2192"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.02.011"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/810961"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.23535"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2008.02.007"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2010.06.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.3945\/ajcn.2008.27336"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.21499"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.nu.16.070196.002515"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200544200"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1143"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bst0080641"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.25741"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00597.2011"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004424-199005000-00015"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmre.1997.1244"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02668096"},{"key":"e_1_2_7_23_1","first-page":"1704","article-title":"T1 relaxation times of 31P metabolites in human liver at 7T","volume":"20","author":"Chemlik M.","year":"2012","journal-title":"Proc. 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