{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:50:50Z","timestamp":1761742250989},"reference-count":20,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","license":[{"start":{"date-parts":[[1999,7,1]],"date-time":"1999-07-01T00:00:00Z","timestamp":930787200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Urology"],"published-print":{"date-parts":[[1999,7]]},"DOI":"10.1097\/00005392-199907000-00072","type":"journal-article","created":{"date-parts":[[2003,11,18]],"date-time":"2003-11-18T19:37:41Z","timestamp":1069184261000},"page":"225-230","source":"Crossref","is-referenced-by-count":12,"title":["INTRAVESICAL BACILLUS CALMETTE-GUERIN (BCG) AS INDUCER OF TUMOR-SUPPRESSING PROTEINS P53 AND P21\n            <sup>Waf1-Cip1<\/sup>\n            DURING TREATMENT OF SUPERFICIAL BLADDER CANCER"],"prefix":"10.1097","volume":"162","author":[{"given":"D.","family":"FONTANA","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"BELLINA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"GALIETTI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"SCOFFONE","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"CAGNAZZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"GUERCIO","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"CAPPIA","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"POZZI","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"10.1097\/00005392-199907000-00072_bib1","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1016\/S0022-5347(17)37452-9","article-title":"Bacillus Calmette-Guerin therapy for superficial bladder cancer: a 10-year followup","volume":"147","author":"Herr","year":"1992","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib2","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0022-5347(17)43909-7","article-title":"Requirement of a thymus dependent immune response for BCG-mediated tumour activity","volume":"137","author":"Ratliff","year":"1987","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib3","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/S0022-5347(17)37668-1","article-title":"Intravesical Evans strain of BCG therapy: quantitative immunohistochemical analysis of the immune response within the bladder wall","volume":"147","author":"Prescott","year":"1992","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0022-5347(17)39365-5","article-title":"Effects of local BCG therapy in patients with bladder carcinoma on immunocompetent cells of the bladder wall","volume":"144","author":"Boehle","year":"1990","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/1097-0142(19920115)69:2<537::AID-CNCR2820690242>3.0.CO;2-3","article-title":"Effects of BCG on cytotoxic activities of peripheral blood lymphocytes against human T24 lined and freshly isolated autologous urinary bladder transitional carcinoma cells in patients with urinary bladder cancer","volume":"69","author":"Mizutani","year":"1992","journal-title":"Cancer"},{"key":"10.1097\/00005392-199907000-00072_bib6","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0022-5347(01)67292-6","article-title":"LAK cell mediated apoptosis of human bladder cancer involves a pH-dependent endonuclease system in the cancer cell: possible mechanism of BCG therapy","volume":"154","author":"Shemtov","year":"1995","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib7","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1159\/000283049","article-title":"Are BCG effects against urinary bladder carcinoma cell line T24 correlated with apoptosis in vitro?","volume":"59","author":"Sasaki","year":"1997","journal-title":"Urol. Int."},{"key":"10.1097\/00005392-199907000-00072_bib8","first-page":"1389","article-title":"P53 nuclear protein accumulation correlates with mutations in the p53 gene, tumor grade, and stage in bladder cancer","volume":"143","author":"Esrig","year":"1993","journal-title":"Am. J. Pathol."},{"key":"10.1097\/00005392-199907000-00072_bib9","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1002\/(SICI)1097-0215(19970926)73:1<38::AID-IJC7>3.0.CO;2-2","article-title":"Interaction between bcl-2 and p21 (waf1\/cip1) in breast carcinomas with wild-type p53","volume":"73","author":"Bukholm","year":"1997","journal-title":"Int. J. Cancer"},{"key":"10.1097\/00005392-199907000-00072_bib10","first-page":"621","article-title":"Waf1\/p21 regulates proliferation but does not mediate p53-dependent apoptosis in urothelial carcinoma cell lines","volume":"12","author":"Makri","year":"1998","journal-title":"Int. J. Oncol."},{"key":"10.1097\/00005392-199907000-00072_bib11","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/sj.onc.1201210","article-title":"Heat shock induces transient p53-dependent cell cycle arrest at G1\/S","volume":"15","author":"Makoto","year":"1997","journal-title":"Oncogene"},{"key":"10.1097\/00005392-199907000-00072_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/0092-8674(93)90500-P","article-title":"Waf1, a potential mediator of p53 tumor suppression","volume":"75","author":"El-Deiry","year":"1993","journal-title":"Cell"},{"key":"10.1097\/00005392-199907000-00072_bib13","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000019721","article-title":"Expression of p21 (waf1\/cip1) protein in transitional cell bladder tumours and its prognostic value","volume":"34","author":"Lipponen","year":"1998","journal-title":"Eur. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib14","first-page":"825","article-title":"Characterization of a panel of novel anti-p21Waf1\/Cip1 monoclonal antibodies and immunochemical analysis of p21Waf1\/Cip1 expression in normal human tissues","volume":"148","author":"Fredersdorf","year":"1996","journal-title":"Am. J. Pathol."},{"key":"10.1097\/00005392-199907000-00072_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1111\/j.1574-695X.1994.tb00456.x","article-title":"Lipoarabinomannan from Mycobacterium tuberculosis modulates the generation of reactive nitrogen intermediates by gamma-interferon activated macrophages","volume":"8","author":"Anthony","year":"1994","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1097\/00005392-199907000-00072_bib16","doi-asserted-by":"crossref","first-page":"3030","DOI":"10.1073\/pnas.89.7.3030","article-title":"DNA damage and mutation in human cells exposed to nitric oxide in vitro","volume":"89","author":"Nguyen","year":"1992","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1097\/00005392-199907000-00072_bib17","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S0022-5347(01)66652-7","article-title":"Incidence of apoptosis, cell proliferation and bcl-2 expression in transitional cell carcinoma of the bladder: association with tumour progression","volume":"155","author":"King","year":"1996","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib18","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1200\/JCO.1996.14.10.2646","article-title":"Overexpression of p53 protein in high-risk population of patients with superficial bladder cancer before and after BCG therapy: correlation to clinical outcome","volume":"14","author":"Lacombe","year":"1996","journal-title":"J. Clin. Oncol."},{"key":"10.1097\/00005392-199907000-00072_bib19","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0022-5347(01)63731-5","article-title":"Correlation between p53 overexpression and response to the Bacillus Calmette-Guerin therapy in a high risk selected population of patients with T1G3 cancer","volume":"159","author":"Lebret","year":"1998","journal-title":"J. Urol."},{"key":"10.1097\/00005392-199907000-00072_bib20","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1093\/ajcp\/108.1.26","article-title":"Enhanced cellular proliferation and p53 accumulation in gastric mucosa chronically infected with Helicobacter pylori","volume":"108","author":"Hibi","year":"1997","journal-title":"Am. J. Clin. Pathol."}],"container-title":["Journal of Urology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534705687459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0022534705687459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/www.jurology.com\/doi\/pdf\/10.1097\/00005392-199907000-00072","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,29]],"date-time":"2022-04-29T05:42:58Z","timestamp":1651210978000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.jurology.com\/doi\/10.1097\/00005392-199907000-00072"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1999,7]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1999,7]]}},"alternative-id":["10.1097\/00005392-199907000-00072"],"URL":"https:\/\/doi.org\/10.1097\/00005392-199907000-00072","relation":{},"ISSN":["0022-5347","1527-3792"],"issn-type":[{"value":"0022-5347","type":"print"},{"value":"1527-3792","type":"electronic"}],"subject":[],"published":{"date-parts":[[1999,7]]}}}