{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:52:56Z","timestamp":1784260376587,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":3015,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2000,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives<\/jats:bold> To investigate the effects of ESS (ESS) on olfactory impairment, disease\u2010specific symptoms, and general quality of well\u2010being In HIV+ patients with sinonasal disease.<\/jats:p><jats:p><jats:bold>Study Design<\/jats:bold> Study 1: Nasal cytology, rhinomanometry, nasal examination including endoscopy, disease\u2010specific sinonasal symptoms, olfactory threshold sensitivity, and odor identification testing were performed before and after ESS in HIV+ patients with sinonasal complaints. Study 2: Quality of well\u2010being was assessed before and after ESS in HIV+ patients with sinonasal complaints and controls.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Significant olfactory sensitivity loss persisted for patients with chronic sinusitis after ESS, suggesting that the impairment in these patients may be due to viral disease rather than inflammation. Significant improvement in other disease\u2010specific symptom scores (nasal obstruction, nasal congestion, headache, sinus pain, etc.) and results of the general quality of well\u2010being assessment showed ESS to be beneficial in the extended health management of HIV illness.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> The current study indicated both olfactory dysfunction and subjective negative symptoms in HIV+ patients with chronic sinusitis. Although olfactory dysfunction remained, ESS was successful in providing marked alleviation of symptomatology in HIV+ patients with chronic sinusitis. The results support ESS as an appropriate treatment option for HIV+ patients with chronic sinusitis.<\/jats:p>","DOI":"10.1097\/00005537-200010000-00026","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T10:21:31Z","timestamp":1069237291000},"page":"1707-1710","source":"Crossref","is-referenced-by-count":24,"title":["Sinonasal Disease and Olfactory Impairment in HIV Disease: Endoscopic Sinus Surgery and Outcome Measures"],"prefix":"10.1002","volume":"110","author":[{"given":"Claire","family":"Murphy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terence M.","family":"Davidson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Jellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaun","family":"Austin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"W.","family":"Christopher Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennard W.","family":"Ellison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Schlotfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1001\/jama.1996.03540020048028","article-title":"Prevalence of HIV infection in the United States, 1984\u20101992.","volume":"276","author":"Karon JM","year":"1996","journal-title":"JAMA"},{"key":"e_1_2_7_3_2","first-page":"5.29\u20101","volume-title":"The AIDS Knowledge Base","author":"Tami TA","year":"1994"},{"key":"e_1_2_7_4_2","first-page":"460","article-title":"Sinusitis in patients with the acquired immunodeficiency syndrome.","volume":"9","author":"Rubin JS","year":"1990","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0009-9260(05)81154-7"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800105"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(92)90045-D"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)00049-O"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(95)02163-9"},{"key":"e_1_2_7_10_2","first-page":"248","article-title":"Olfactory identification deficits in HIV infection.","volume":"148","author":"Brody D","year":"1990","journal-title":"Am J Psychiatry"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(83)80068-4"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(90)90014-Q"},{"key":"e_1_2_7_13_2","first-page":"191","article-title":"Olfactory self\u2010and cross\u2010adaptation: effects of time of adaptation and perceived odor intensity.","volume":"2","author":"Berglund B","year":"1978","journal-title":"Sens Proc"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198303000-00017"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609400203"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800110054002"},{"key":"e_1_2_7_17_2","volume-title":"Quality of Life and Pharmacoeconomics in Clinical Trials","author":"Kaplan RM","year":"1996"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2F00005537-200010000-00026","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/00005537-200010000-00026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,29]],"date-time":"2023-10-29T11:54:44Z","timestamp":1698580484000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/00005537-200010000-00026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2000,10]]},"references-count":16,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2000,10]]}},"alternative-id":["10.1097\/00005537-200010000-00026"],"URL":"https:\/\/doi.org\/10.1097\/00005537-200010000-00026","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2000,10]]}}}