{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T23:34:03Z","timestamp":1772148843279,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":2254,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2002,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives<\/jats:bold> Wegener's granulomatosis is a granulomatous and necrotizing vasculitis that classically involves the respiratory and renal systems. The goal of the study was to define clinical and pathological characteristics in a subgroup of patients with the changes of Wegener's granulomatosis involving the orbit.<\/jats:p><jats:p><jats:bold>Study Design<\/jats:bold> Retrospective study.<\/jats:p><jats:p><jats:bold>Methods<\/jats:bold> A database search identified 15 patients with the histological changes of Wegener's granulomatosis of the orbit presenting over a 23\u2010year period. A review of the histological specimens, radiological studies, and patient charts was performed. Additional follow\u2010up data were obtained through patient interviews.<\/jats:p><jats:p><jats:bold>Results<\/jats:bold> Of 15 patients (median age, 54 y) with Wegener's granulomatosis of the orbit identified, the disease was limited to the orbit in 12 patients; 3 patients had additional sinonasal involvement. All patients underwent various surgical procedures followed by medical treatment (cyclophosphamide and prednisone). Specimens showed characteristic histopathological features of Wegener's granulomatosis. Follow\u2010up data were available for 12 patients with a median period of 5 years. In the group with only orbital involvement, none of the patients developed systemic progression of Wegener's granulomatosis. Only one patient had multiple local recurrences and later developed contralateral orbital Wegener's granulomatosis.<\/jats:p><jats:p><jats:bold>Conclusions<\/jats:bold> Wegener's granulomatosis limited to the orbit is a localized form of the disease without systemic progression. Diagnostic surgical procedures followed by aggressive medical treatment results in good outcome, although local recurrence may occur.<\/jats:p>","DOI":"10.1097\/00005537-200211000-00007","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T11:05:03Z","timestamp":1069239903000},"page":"1945-1950","source":"Crossref","is-referenced-by-count":68,"title":["Wegener's Granulomatosis of the Orbit: A Clinicopathological Study of 15 Patients"],"prefix":"10.1002","volume":"112","author":[{"given":"Frank P.","family":"Fechner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William C.","family":"Faquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ben Z.","family":"Pilch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"533","article-title":"Wegener's granulomatosis: pathology and review of the literature","volume":"58","author":"Godman GC","year":"1954","journal-title":"Arch Pathol"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-116-6-488"},{"key":"e_1_2_6_4_2","first-page":"309","article-title":"Wegener's granulomatosis: survey of 701 patients in North America\u2014changes in outcome in the 1990s","volume":"29","author":"Abdou NI","year":"2002","journal-title":"J Rheumatol"},{"key":"e_1_2_6_5_2","first-page":"344","article-title":"Outcome analysis of patients with vasculitis associated with antineutrophil cytoplasmic antibodies","volume":"52","author":"Brijker F","year":"1999","journal-title":"Clin Nephrol"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(66)90214-2"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9343(70)80029-8"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197311000-00002"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-98-1-76"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000027736"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002341-199911000-00022"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(77)90125-5"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(01)00655-8"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(83)34574-7"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90030-S"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0046-8177(91)90028-N"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199006000-00006"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/15.5.611"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.65.3.135"},{"key":"e_1_2_6_20_2","first-page":"34","article-title":"Wegener's granulomatosis","volume":"18","author":"Yi ES","year":"2001","journal-title":"Semin Diagn Pathol"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-123-12-199512150-00005"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2F00005537-200211000-00007","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/00005537-200211000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T11:32:45Z","timestamp":1700393565000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/00005537-200211000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2002,11]]},"references-count":20,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2002,11]]}},"alternative-id":["10.1097\/00005537-200211000-00007"],"URL":"https:\/\/doi.org\/10.1097\/00005537-200211000-00007","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2002,11]]}}}