{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:18:20Z","timestamp":1787066300383,"version":"build-2736575974"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":2193,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2003,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    <jats:bold>Objective<\/jats:bold>\n                    To determine the sensitivity, specificity, and diagnostic accuracy of paranasal sinus computed tomography (CT) in the diagnosis of chronic rhinosinusitis (CRS).\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Study Design<\/jats:bold>\n                    Prospective dual cohort study.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Methods<\/jats:bold>\n                    One hundred seventy\u2010one consecutive patients undergoing endoscopic sinus surgery for CRS were evaluated with CT and staged according to the Lund system. Histopathological findings from sinus specimens were reviewed and graded. A second contemporaneous control group of 130 patients undergoing CT of the sinus regions for other reasons but without a diagnosis of CRS was also staged. Sensitivity, specificity, and the receiver\u2013operator characteristic were determined for the sinus CT in the diagnosis of CRS. Positive and negative predictive values were also computed.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Results<\/jats:bold>\n                    In the disease\u2010positive group of patients with CRS, the mean Lund score was 9.8 (95% confidence interval, 9.0\u201310.6). The mean inflammatory grade on histopathological study was 2.3 (range, 0\u20134). For the control group (without disease), the mean Lund score was 4.3 (95% confidence interval, 3.5\u20135.0). The AUC for the receiver\u2013operator characteristic was 0.802 (\n                    <jats:italic>P<\/jats:italic>\n                    &lt;.001). Selecting a Lund score cut\u2010off value of greater than 2 as abnormal, the sinus CT exhibited sensitivity and specificity of 94% and 41%, respectively. Increasing the cut\u2010off value to 4 changed the sensitivity and specificity to 85% and 59%, respectively.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Conclusions<\/jats:bold>\n                    The paranasal sinus CT scan exhibits good sensitivity and above\u2010average specificity for the diagnosis of CRS. When added to the history and physical findings, CT may add to the diagnostic accuracy of CRS.\n                  <\/jats:p>","DOI":"10.1097\/00005537-200301000-00023","type":"journal-article","created":{"date-parts":[[2003,11,19]],"date-time":"2003-11-19T06:06:38Z","timestamp":1069221998000},"page":"125-129","source":"Crossref","is-referenced-by-count":164,"title":["The Accuracy of Computed Tomography in the Diagnosis of Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"113","author":[{"given":"Neil","family":"Bhattacharyya","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin P.","family":"Fried","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770004-4"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/crad.2000.0550"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770005-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119324"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1259\/bjr.71.850.10211059"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002590000428"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.2500\/105065801779954184"},{"key":"e_1_2_6_10_2","unstructured":"http:\/\/www.cdc.gov\/nchs\/fastats\/sinuses.htm"},{"key":"e_1_2_6_11_2","unstructured":"http:\/\/www.ampainsoc.org\/bulletin\/jul99\/clinic2.htm"},{"key":"e_1_2_6_12_2","first-page":"1","article-title":"Current estimates from the National Health Interview Survey, 1995","volume":"199","author":"Benson V","year":"1998","journal-title":"Vital Health Stat 10:"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1177\/019459989110400409"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1988.01860200040012"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(97)70129-3"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900110039006"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.116779"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.11.1369"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200110000-00022"},{"key":"e_1_2_6_20_2","first-page":"243","volume-title":"Basic and Clinical Biostatistics","author":"Dawson\u2010Saunders B","year":"1994"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0258(19980430)17:8<857::AID-SIM777>3.0.CO;2-E"},{"key":"e_1_2_6_22_2","first-page":"847","article-title":"First\u2010line management of sinusitis: a national problem?","volume":"103","author":"Kennedy DW","year":"1990","journal-title":"Overview Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_23_2","unstructured":"BhattacharyyaN.The economic burden and symptom manifestations of chronic rhinosinusitis.Am J Rhinol.In press."}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2F00005537-200301000-00023","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/00005537-200301000-00023","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,16]],"date-time":"2023-11-16T19:29:06Z","timestamp":1700162946000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/00005537-200301000-00023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,1]]},"references-count":22,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2003,1]]}},"alternative-id":["10.1097\/00005537-200301000-00023"],"URL":"https:\/\/doi.org\/10.1097\/00005537-200301000-00023","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2003,1]]}}}