{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:00:54Z","timestamp":1791356454290,"version":"4.3.1"},"reference-count":85,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1097\/01.bor.0000218948.42730.39","type":"journal-article","created":{"date-parts":[[2006,3,30]],"date-time":"2006-03-30T05:15:26Z","timestamp":1143695726000},"page":"268-276","source":"Crossref","is-referenced-by-count":69,"title":["Role of adhesion molecules in synovial inflammation"],"prefix":"10.1097","volume":"18","author":[{"given":"Sandeep K","family":"Agarwal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael B","family":"Brenner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210128","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/0092-8674(94)90337-9","article-title":"Traffic signals for lymphocyte recirculation and leukocyte emigration: the multistep paradigm","volume":"76","author":"Springer","year":"1994","journal-title":"Cell"},{"key":"R2-10-20210128","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1006\/smim.2001.0344","article-title":"Selectins: critical mediators of leukocyte recruitment","volume":"14","author":"Patel","year":"2002","journal-title":"Semin Immunol"},{"key":"R3-10-20210128","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0092-8674(02)00971-6","article-title":"Integrins: bidirectional, allosteric signaling machines","volume":"110","author":"Hynes","year":"2002","journal-title":"Cell"},{"key":"R4-10-20210128","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.tcb.2004.10.005","article-title":"Integrins: versatile integrators of extracellular signals","volume":"14","author":"Ffrench-Constant","year":"2004","journal-title":"Trends Cell Biol"},{"key":"R5-10-20210128","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0002-9343(99)00058-3","article-title":"Structure and function of cell adhesion molecules","volume":"106","author":"Petruzzelli","year":"1999","journal-title":"Am J Med"},{"key":"R6-10-20210128","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1146\/annurev.cellbio.19.011102.111135","article-title":"Cadherins as modulators of cellular phenotype","volume":"19","author":"Wheelock","year":"2003","journal-title":"Annu Rev Cell Dev Biol"},{"key":"R7-10-20210128","doi-asserted-by":"crossref","first-page":"32905","DOI":"10.1074\/jbc.M200300200","article-title":"Signal transduction from N-cadherin increases Bcl-2. Regulation of the phosphatidylinositol 3-kinase\/Akt pathway by homophilic adhesion and actin cytoskeletal organization","volume":"277","author":"Tran","year":"2002","journal-title":"J Biol Chem"},{"key":"R8-10-20210128","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1083\/jcb.151.6.1193","article-title":"N-Cadherin extracellular repeat 4 mediates epithelial to mesenchymal transition and increased motility","volume":"151","author":"Kim","year":"2000","journal-title":"J Cell Biol"},{"key":"R9-10-20210128","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1083\/jcb.148.4.779","article-title":"Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis","volume":"148","author":"Hazan","year":"2000","journal-title":"J Cell Biol"},{"key":"R10-10-20210128","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","article-title":"A causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"key":"R11-10-20210128","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0304-3835(95)04047-1","article-title":"Simultaneous expression of cadherin-11 in signet-ring cell carcinoma and stromal cells of diffuse-type gastric cancer","volume":"99","author":"Shibata","year":"1996","journal-title":"Cancer Lett"},{"key":"R12-10-20210128","first-page":"313","article-title":"Immunolocalization of endothelial and leukocyte adhesion molecules in human rheumatoid and osteoarthritic synovial tissues","volume":"64","author":"Koch","year":"1991","journal-title":"Lab Invest"},{"key":"R13-10-20210128","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1006\/clin.1995.1149","article-title":"Expression of adhesion molecules in early rheumatoid synovial tissue","volume":"77","author":"Tak","year":"1995","journal-title":"Clin Immunol Immunopathol"},{"key":"R14-10-20210128","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1002\/art.1780360203","article-title":"Adhesion molecule expression in human synovial tissue","volume":"36","author":"Johnson","year":"1993","journal-title":"Arthritis Rheum"},{"key":"R15-10-20210128","first-page":"1019","article-title":"Expression of integrin family of cell adhesion receptors in rheumatoid synovium. Alpha 6 integrin subunit in normal and hyperplastic synovial lining cell layer","volume":"142","author":"Nikkari","year":"1993","journal-title":"Am J Pathol"},{"key":"R16-10-20210128","first-page":"16","article-title":"Localization of the alpha v subfamily of integrins and their putative ligands in synovial lining cell layer","volume":"22","author":"Nikkari","year":"1995","journal-title":"J Rheumatol"},{"key":"R17-10-20210128","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1002\/art.1780370211","article-title":"Differential distribution of intercellular adhesion molecules (ICAM-1, ICAM-2, and ICAM-3) and the MS-1 antigen in normal and diseased human synovia. Their possible pathogenetic and clinical significance in rheumatoid arthritis","volume":"37","author":"Szekanecz","year":"1994","journal-title":"Arthritis Rheum"},{"key":"R18-10-20210128","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/anr.1780320105","article-title":"Immunohistologic analysis of the distribution of cell adhesion molecules within the inflammatory synovial microenvironment","volume":"32","author":"Hale","year":"1989","journal-title":"Arthritis Rheum"},{"key":"R19-10-20210128","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1002\/art.1780311003","article-title":"Phenotypic analysis of synovial tissue and peripheral blood lymphocytes isolated from patients with rheumatoid arthritis","volume":"31","author":"Cush","year":"1988","journal-title":"Arthritis Rheum"},{"key":"R20-10-20210128","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1172\/JCI115338","article-title":"Upregulated expression and function of VLA-4 fibronectin receptors on human activated T cells in rheumatoid arthritis","volume":"88","author":"Laffon","year":"1991","journal-title":"J Clin Invest"},{"key":"R21-10-20210128","first-page":"1873","article-title":"Alternatively spliced CS-1 fibronectin isoform and its receptor VLA-4 in rheumatoid arthritis synovium","volume":"24","author":"Muller-Ladner","year":"1997","journal-title":"J Rheumatol"},{"key":"R22-10-20210128","doi-asserted-by":"crossref","first-page":"6482","DOI":"10.4049\/jimmunol.151.11.6482","article-title":"Differential expression in rheumatoid synovium and synovial fluid of alpha 4 beta 7 integrin. A novel receptor for fibronectin and vascular cell adhesion molecule-1","volume":"151","author":"Lazarovits","year":"1993","journal-title":"J Immunol"},{"key":"R23-10-20210128","first-page":"2754","article-title":"Expression of the alphaEbeta7 integrin by mast cells in rheumatoid synovium","volume":"27","author":"Gibson","year":"2000","journal-title":"J Rheumatol"},{"key":"R24-10-20210128","first-page":"1691","article-title":"Altered integrin expression in rheumatoid synovial lining type B cells: in vitro cytokine regulation of alpha 1 beta 1, alpha 6 beta 1, and alpha v beta 5 integrins","volume":"23","author":"Pirila","year":"1996","journal-title":"J Rheumatol"},{"key":"R25-10-20210128","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1083\/jcb.129.3.867","article-title":"Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin","volume":"129","author":"Huhtala","year":"1995","journal-title":"J Cell Biol"},{"key":"R26-10-20210128","first-page":"613","article-title":"Transforming growth factor-beta and platelet derived growth factor regulation of fibrillar fibronectin matrix formation by synovial fibroblasts","volume":"25","author":"Sarkissian","year":"1998","journal-title":"J Rheumatol"},{"key":"R27-10-20210128","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1136\/ard.56.12.729","article-title":"Differential expression and functional behaviour of the alpha v and beta 3 integrin subunits in cytokine stimulated fibroblast-like cells derived from synovial tissue of rheumatoid arthritis and osteoarthritis in vitro","volume":"56","author":"Rinaldi","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"R28-10-20210128","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/ard.56.1.45","article-title":"Increased expression of integrins on fibroblast-like synoviocytes from rheumatoid arthritis in vitro correlates with enhanced binding to extracellular matrix proteins","volume":"56","author":"Rinaldi","year":"1997","journal-title":"Ann Rheum Dis"},{"key":"R29-10-20210128","first-page":"82","article-title":"Expression of vascular cell adhesion molecule-1 in normal and inflamed synovium","volume":"68","author":"Wilkinson","year":"1993","journal-title":"Lab Invest"},{"key":"R30-10-20210128","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.4049\/jimmunol.149.4.1424","article-title":"Alpha 4\/beta 1 integrin (VLA-4) ligands in arthritis. Vascular cell adhesion molecule-1 expression in synovium and on fibroblast-like synoviocytes","volume":"149","author":"Morales-Ducret","year":"1992","journal-title":"J Immunol"},{"key":"R31-10-20210128","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1084\/jem.20041545","article-title":"Cadherin-11 provides specific cellular adhesion between fibroblast-like synoviocytes","volume":"200","author":"Valencia","year":"2004","journal-title":"J Exp Med"},{"key":"R32-10-20210128","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/anr.1780320405","article-title":"Very late activation antigen on synovial fluid T cells from patients with rheumatoid arthritis and other rheumatic diseases","volume":"32","author":"Laffon","year":"1989","journal-title":"Arthritis Rheum"},{"key":"R33-10-20210128","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1002\/eji.1830221119","article-title":"Integrins and other adhesion molecules on lymphocytes from synovial fluid and peripheral blood of rheumatoid arthritis patients","volume":"22","author":"Takahashi","year":"1992","journal-title":"Eur J Immunol"},{"key":"R34-10-20210128","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/art.1780390315","article-title":"Regulation of adhesion molecule expression by human synovial microvascular endothelial cells in vitro","volume":"39","author":"To","year":"1996","journal-title":"Arthritis Rheum"},{"key":"R35-10-20210128","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1172\/JCI115734","article-title":"Increased binding of synovial T lymphocytes from rheumatoid arthritis to endothelial-leukocyte adhesion molecule-1 (ELAM-1) and vascular cell adhesion molecule-1 (VCAM-1)","volume":"89","author":"Postigo","year":"1992","journal-title":"J Clin Invest"},{"key":"R36-10-20210128","doi-asserted-by":"crossref","first-page":"2609","DOI":"10.1172\/JCI116500","article-title":"Monocyte-endothelial adhesion in chronic rheumatoid arthritis. In situ detection of selectin and integrin-dependent interactions","volume":"91","author":"Grober","year":"1993","journal-title":"J Clin Invest"},{"key":"R37-10-20210128","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/eji.1830270628","article-title":"The role of E- and P-selectin in neutrophil and monocyte migration in adjuvant-induced arthritis in the rat","volume":"27","author":"Walter","year":"1997","journal-title":"Eur J Immunol"},{"key":"R38-10-20210128","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1093\/intimm\/12.2.141","article-title":"The role of alpha(4) and LFA-1 integrins in selectin-independent monocyte and neutrophil migration to joints of rats with adjuvant arthritis","volume":"12","author":"Birner","year":"2000","journal-title":"Int Immunol"},{"key":"R39-10-20210128","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1046\/j.1440-1711.2003.01187.x","article-title":"Differential roles of VLA-4(CD49d\/CD29) and LFA-1(CD11a\/CD18) integrins and E- and P-selectin during developing and established active or adoptively transferred adjuvant arthritis in the rat","volume":"81","author":"Issekutz","year":"2003","journal-title":"Immunol Cell Biol"},{"key":"R40-10-20210128","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1084\/jem.181.3.1197","article-title":"Monocyte migration to arthritis in the rat utilizes both CD11\/CD18 and very late activation antigen 4 integrin mechanisms","volume":"181","author":"Issekutz","year":"1995","journal-title":"J Exp Med"},{"key":"R41-10-20210128","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1046\/j.1365-2567.1996.d01-695.x","article-title":"Treatment of established adjuvant arthritis in rats with monoclonal antibody to CD18 and very late activation antigen-4 integrins suppresses neutrophil and T-lymphocyte migration to the joints and improves clinical disease","volume":"88","author":"Issekutz","year":"1996","journal-title":"Immunology"},{"key":"R42-10-20210128","doi-asserted-by":"crossref","first-page":"3337","DOI":"10.4049\/jimmunol.164.6.3337","article-title":"Alpha 4 integrin-dependent leukocyte recruitment does not require VCAM-1 in a chronic model of inflammation","volume":"164","author":"Johnston","year":"2000","journal-title":"J Immunol"},{"key":"R43-10-20210128","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1749-6632.2003.tb06042.x","article-title":"Ectopic germinal center formation in rheumatoid synovitis","volume":"987","author":"Weyand","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"R44-10-20210128","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.4049\/jimmunol.167.2.1072","article-title":"Lymphoid neogenesis in rheumatoid synovitis","volume":"167","author":"Takemura","year":"2001","journal-title":"J Immunol"},{"key":"R45-10-20210128","doi-asserted-by":"crossref","first-page":"2995","DOI":"10.1182\/blood.V88.8.2995.bloodjournal8882995","article-title":"Follicular dendritic cells adhere to fibronectin and laminin fibers via their respective receptors","volume":"88","author":"Ogata","year":"1996","journal-title":"Blood"},{"key":"R46-10-20210128","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1126\/science.1697696","article-title":"Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110","volume":"249","author":"Freedman","year":"1990","journal-title":"Science"},{"key":"R47-10-20210128","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1084\/jem.173.6.1297","article-title":"Adhesion of human B cells to follicular dendritic cells involves both the lymphocyte function-associated antigen 1\/intercellular adhesion molecule 1 and very late antigen 4\/vascular cell adhesion molecule 1 pathways","volume":"173","author":"Koopman","year":"1991","journal-title":"J Exp Med"},{"key":"R48-10-20210128","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1126\/science.1092053","article-title":"Cell migration: integrating signals from front to back","volume":"302","author":"Ridley","year":"2003","journal-title":"Science"},{"key":"R49-10-20210128","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1242\/jcs.00876","article-title":"T-cell integrins: more than just sticking points","volume":"116","author":"Hogg","year":"2003","journal-title":"J Cell Sci"},{"key":"R50-10-20210128","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.4049\/jimmunol.164.2.1110","article-title":"Rheumatoid arthritis synovial stromal cells inhibit apoptosis and up-regulate Bcl-xL expression by B cells in a CD49\/CD29-CD106-dependent mechanism","volume":"164","author":"Hayashida","year":"2000","journal-title":"J Immunol"},{"key":"R51-10-20210128","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/25764","article-title":"Three-dimensional segregation of supramolecular activation clusters in T cells","volume":"395","author":"Monks","year":"1998","journal-title":"Nature"},{"key":"R52-10-20210128","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/S1074-7613(00)80376-3","article-title":"Distinct roles for LFA-1 and CD28 during activation of naive T cells: adhesion versus costimulation","volume":"7","author":"Bachmann","year":"1997","journal-title":"Immunity"},{"key":"R53-10-20210128","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1242\/jcs.114.22.3957","article-title":"The role of lipid rafts in signalling and membrane trafficking in T lymphocytes","volume":"114","author":"Alonso","year":"2001","journal-title":"J Cell Sci"},{"key":"R54-10-20210128","first-page":"458","article-title":"Rheumatoid synovial fibroblasts are stimulated by the cellular adhesion to T cells through lymphocyte function associated antigen-1\/intercellular adhesion molecule-1","volume":"24","author":"Nakatsuka","year":"1997","journal-title":"J Rheumatol"},{"key":"R55-10-20210128","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1083\/jcb.14.2.207","article-title":"Electron microscopy of the human synovial membrane","volume":"14","author":"Barland","year":"1962","journal-title":"J Cell Biol"},{"key":"R56-10-20210128","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.4049\/jimmunol.162.3.1772","article-title":"Integrin engagement regulates proliferation and collagenase expression of rheumatoid synovial fibroblasts","volume":"162","author":"Sarkissian","year":"1999","journal-title":"J Immunol"},{"key":"R58-10-20210128","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1002\/art.1780400715","article-title":"Interleukin-1beta-stimulated invasion of articular cartilage by rheumatoid synovial fibroblasts is inhibited by antibodies to specific integrin receptors and by collagenase inhibitors","volume":"40","author":"Wang","year":"1997","journal-title":"Arthritis Rheum"},{"key":"R59-10-20210128","doi-asserted-by":"crossref","first-page":"5990","DOI":"10.4049\/jimmunol.164.11.5990","article-title":"NF-kappa B regulates VCAM-1 expression on fibroblast-like synoviocytes","volume":"164","author":"Li","year":"2000","journal-title":"J Immunol"},{"key":"R60-10-20210128","doi-asserted-by":"crossref","first-page":"34679","DOI":"10.1074\/jbc.M206337200","article-title":"Signal transduction pathways involved in rheumatoid arthritis synovial fibroblast interleukin-18-induced vascular cell adhesion molecule-1 expression","volume":"277","author":"Morel","year":"2002","journal-title":"J Biol Chem"},{"key":"R61-10-20210128","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/jmicro\/53.1.93","article-title":"Three-dimensional expression of adhesion molecules on the superficial synovial intima of LPS-induced arthritis of the mouse knee analyzed by immuno-SEM","volume":"53","author":"Liang","year":"2004","journal-title":"J Electron Microsc (Tokyo)"},{"key":"R62-10-20210128","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/S0065-2776(04)82005-4","article-title":"The role of antibodies in mouse models of rheumatoid arthritis, and relevance to human disease","volume":"82","author":"Monach","year":"2004","journal-title":"Adv Immunol"},{"key":"R63-10-20210128","doi-asserted-by":"crossref","first-page":"2844","DOI":"10.4049\/jimmunol.163.5.2844","article-title":"Acceleration and increased severity of collagen-induced arthritis in P-selectin mutant mice","volume":"163","author":"Bullard","year":"1999","journal-title":"J Immunol"},{"key":"R64-10-20210128","doi-asserted-by":"crossref","first-page":"R959","DOI":"10.1186\/ar1770","article-title":"Accelerated development of arthritis in mice lacking endothelial selectins","volume":"7","author":"Ruth","year":"2005","journal-title":"Arthritis Res Ther"},{"key":"R65-10-20210128","doi-asserted-by":"crossref","first-page":"4167","DOI":"10.4049\/jimmunol.147.12.4167","article-title":"ICAM-1-dependent pathway is critically involved in the pathogenesis of adjuvant arthritis in rats","volume":"147","author":"Iigo","year":"1991","journal-title":"J Immunol"},{"key":"R66-10-20210128","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/0008-8749(92)90294-Y","article-title":"The effect of anti-adhesion molecule antibody on the development of collagen-induced arthritis","volume":"142","author":"Kakimoto","year":"1992","journal-title":"Cell Immunol"},{"key":"R67-10-20210128","doi-asserted-by":"crossref","first-page":"3153","DOI":"10.4049\/jimmunol.157.7.3153","article-title":"Reduced susceptibility to collagen-induced arthritis in mice deficient in intercellular adhesion molecule-1","volume":"157","author":"Bullard","year":"1996","journal-title":"J Immunol"},{"key":"R68-10-20210128","doi-asserted-by":"crossref","first-page":"3668","DOI":"10.4049\/jimmunol.174.6.3668","article-title":"Manifestations of inflammatory arthritis are critically dependent on LFA-1","volume":"174","author":"Watts","year":"2005","journal-title":"J Immunol"},{"key":"R69-10-20210128","doi-asserted-by":"crossref","first-page":"245","DOI":"10.3109\/08916939509001943","article-title":"Therapeutic effects of antibodies against adhesion molecules in murine collagen type II-induced arthritis","volume":"21","author":"Zeidler","year":"1995","journal-title":"Autoimmunity"},{"key":"R70-10-20210128","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/art.1780350508","article-title":"Amelioration of antigen-induced arthritis in rabbits treated with monoclonal antibodies to leukocyte adhesion molecules","volume":"35","author":"Jasin","year":"1992","journal-title":"Arthritis Rheum"},{"key":"R71-10-20210128","doi-asserted-by":"crossref","first-page":"3377","DOI":"10.1002\/art.20557","article-title":"Quantification of cortical bone loss and repair for therapeutic evaluation in collagen-induced arthritis, by micro-computed tomography and automated image analysis","volume":"50","author":"Barck","year":"2004","journal-title":"Arthritis Rheum"},{"key":"R72-10-20210128","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1111\/j.1365-2567.1996.tb00021.x","article-title":"Transfer of type II collagen-induced arthritis from DBA\/1 to severe combined immunodeficiency mice can be prevented by blockade of Mac-1","volume":"88","author":"Taylor","year":"1996","journal-title":"Immunology"},{"key":"R73-10-20210128","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/A:1023282701505","article-title":"Blockade of integrin VLA-4 prevents inflammation and matrix metalloproteinase expression in a murine model of accelerated collagen-induced arthritis","volume":"27","author":"Raychaudhuri","year":"2003","journal-title":"Inflammation"},{"key":"R74-10-20210128","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/1099-1387(200008)6:8<398::AID-PSC270>3.0.CO;2-1","article-title":"Potent cyclic peptide inhibitors of VLA-4 (alpha4beta1 integrin)-mediated cell adhesion. Discovery of compounds like cyclo(MePhe-Leu-Asp-Val-D-Arg-D-Arg) (ZD7349) compatible with depot formulation","volume":"6","author":"Dutta","year":"2000","journal-title":"J Pept Sci"},{"key":"R75-10-20210128","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1084\/jem.183.5.2329","article-title":"Infectious susceptibility and severe deficiency of leukocyte rolling and recruitment in E-selectin and P-selectin double mutant mice","volume":"183","author":"Bullard","year":"1996","journal-title":"J Exp Med"},{"key":"R76-10-20210128","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1056\/NEJMra032906","article-title":"New drugs for rheumatoid arthritis","volume":"350","author":"Olsen","year":"2004","journal-title":"N Engl J Med"},{"key":"R77-10-20210128","first-page":"1453","article-title":"Gold treatment of rheumatoid arthritis decreases synovial expression of the endothelial leukocyte adhesion receptor ELAM-1","volume":"18","author":"Corkill","year":"1991","journal-title":"J Rheumatol"},{"key":"R78-10-20210128","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/rheumatology\/40.9.965","article-title":"Successful treatment of rheumatoid arthritis is associated with a reduction in synovial membrane cytokines and cell adhesion molecule expression","volume":"40","author":"Smith","year":"2001","journal-title":"Rheumatology (Oxford)"},{"key":"R79-10-20210128","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/art.1780370703","article-title":"Treatment of refractory rheumatoid arthritis with a monoclonal antibody to intercellular adhesion molecule 1","volume":"37","author":"Kavanaugh","year":"1994","journal-title":"Arthritis Rheum"},{"key":"R80-10-20210128","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1002\/art.1780400511","article-title":"Repeat treatment of rheumatoid arthritis patients with a murine anti-intercellular adhesion molecule 1 monoclonal antibody","volume":"40","author":"Kavanaugh","year":"1997","journal-title":"Arthritis Rheum"},{"key":"R81-10-20210128","doi-asserted-by":"crossref","first-page":"3073","DOI":"10.1001\/jama.290.23.3073","article-title":"Efalizumab for patients with moderate to severe plaque psoriasis: a randomized controlled trial","volume":"290","author":"Gordon","year":"2003","journal-title":"JAMA"},{"key":"R82-10-20210128","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1056\/NEJMoa020696","article-title":"A controlled trial of natalizumab for relapsing multiple sclerosis","volume":"348","author":"Miller","year":"2003","journal-title":"N Engl J Med"},{"key":"R83-10-20210128","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1056\/NEJMoa043335","article-title":"Natalizumab induction and maintenance therapy for Crohn's disease","volume":"353","author":"Sandborn","year":"2005","journal-title":"N Engl J Med"},{"key":"R84-10-20210128","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1056\/NEJMoa042982","article-title":"Treatment of ulcerative colitis with a humanized antibody to the alpha4beta7 integrin","volume":"352","author":"Feagan","year":"2005","journal-title":"N Engl J Med"},{"key":"R85-10-20210128","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1046\/j.1365-2133.2003.05239.x","article-title":"Alefacept therapy produces remission for patients with chronic plaque psoriasis","volume":"148","author":"Krueger","year":"2003","journal-title":"Br J Dermatol"},{"key":"R86-10-20210128","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1056\/NEJMoa051782","article-title":"Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis","volume":"353","author":"Kleinschmidt-DeMasters","year":"2005","journal-title":"N Engl J Med"}],"container-title":["Current Opinion in Rheumatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/01.bor.0000218948.42730.39","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:23:07Z","timestamp":1785856987000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00002281-200605000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":85,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1097\/01.bor.0000218948.42730.39","relation":{},"ISSN":["1040-8711"],"issn-type":[{"value":"1040-8711","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}