{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:20:58Z","timestamp":1785860458369,"version":"3.56.0"},"reference-count":36,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec>\n                    <jats:title\/>\n                    <jats:p>Spinal epidural lipomatosis (SEL) is accumulation of unencapsulated fat tissue within the epidural space of the spinal canal. The most common cause of SEL is corticosteroid therapy, whereas most of the non\u2013corticosteroid-dependent cases are idiopathic. If unrecognized, it may result in diagnostic confusion with other neuropathic or myelopathic conditions. We report 2 cases of SEL. The first case is of a 30-year-old man who received corticosteroid therapy for an acute and probably immune-mediated demyelinating process. Subsequently, the addition of compressive effects of SEL resulted in diagnostic confusion and initial workup at other centers for spinal cord malignancy and vascular malformation. The patient's symptoms improved after decompression surgery. The second case is of a 63-year-old woman with a history of type 1 diabetes mellitus that presented with increasing numbness in the lower extremities. She was initially diagnosed with diabetic neuropathy; however, the presence of myelopathic signs led to further investigation and diagnosis of SEL. Decompression surgery resulted in improvement of symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1097\/01.cnd.0000211400.12372.d3","type":"journal-article","created":{"date-parts":[[2006,4,19]],"date-time":"2006-04-19T04:11:24Z","timestamp":1145419884000},"page":"133-140","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":3,"title":["Myeloneuropathic Presentation of Spinal Epidural Lipomatosis"],"prefix":"10.1097","volume":"7","author":[{"given":"Shahram","family":"Izadyar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin Y.","family":"Kwan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadollah","family":"Harati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-7-20240808","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1212\/WNL.42.6.1250","article-title":"Spinal epidural lipomatosis in Cushing's syndrome secondary to an adrenal tumor","volume":"42","author":"Noel","year":"1992","journal-title":"Neurology"},{"key":"R2-7-20240808","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1212\/WNL.45.12.2281","article-title":"Symptomatic spinal epidural lipomatosis in a patient with Cushing's disease","volume":"45","author":"Sivakumar","year":"1995","journal-title":"Neurology"},{"key":"R3-7-20240808","first-page":"207","article-title":"Epidural lipomatosis not induced by corticosteroid therapy. Three cases including one in a patient with primary Cushing's disease (review of the literature)","volume":"63","author":"Benamou","year":"1996","journal-title":"Rev Rhum Engl Ed"},{"key":"R4-7-20240808","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1056\/NEJM199910283411814","article-title":"Spinal epidural lipomatosis in a patient with the ectopic corticotropin syndrome","volume":"341","author":"Koch","year":"1999","journal-title":"N Engl J Med"},{"key":"R5-7-20240808","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/S1297-319X(02)00382-2","article-title":"Spinal epidural lipomatosis revealing endogenous Cushing's syndrome","volume":"69","author":"Dumont-Fischer","year":"2002","journal-title":"Joint Bone Spine"},{"key":"R6-7-20240808","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1530\/eje.0.1510765","article-title":"Symptomatic epidural lipomatosis in ectopic Cushing's syndrome","volume":"151","author":"Bodelier","year":"2004","journal-title":"Eur J Endocrinol"},{"key":"R7-7-20240808","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1097\/00002517-199912000-00013","article-title":"Epidural lipomatosis complicating lumbar steroid injections","volume":"12","author":"McCullen","year":"1999","journal-title":"J Spinal Disord"},{"key":"R8-7-20240808","first-page":"162","article-title":"Symptomatic spinal epidural lipomatosis after local epidural corticosteroid injections: case report","volume":"45","author":"Sandberg","year":"1999","journal-title":"Neurosurgery"},{"key":"R9-7-20240808","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/j.1600-0838.1997.tb00166.x","article-title":"Spinal epidural lipomatosis. Case report and review of the literature","volume":"7","author":"Fiirgaard","year":"1997","journal-title":"Scand J Med Sci Sports"},{"key":"R10-7-20240808","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1007\/BF00314138","article-title":"Spinal epidural lipomatosis: report of a case secondary to hypothyroidism and review of literature","volume":"234","author":"Toshniwal","year":"1987","journal-title":"J Neurol"},{"key":"R11-7-20240808","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/00002826-200201000-00009","article-title":"Epidural lipomatosis secondary to indinavir in an HIV-positive patient","volume":"25","author":"Cersosimo","year":"2002","journal-title":"Clin Neuropharmacol"},{"key":"R12-7-20240808","doi-asserted-by":"crossref","first-page":"E90","DOI":"10.1086\/319209","article-title":"Spinal epidural lipomatosis in a human immunodeficiency virus-positive patient receiving steroids and protease inhibitor therapy","volume":"32","author":"Ebright","year":"2001","journal-title":"Clin Infect Dis"},{"key":"R13-7-20240808","first-page":"858","article-title":"Spinal epidural lipomatosis associated with Paget's disease of bone","volume":"144","author":"Koziarz","year":"2002","journal-title":"Neuroradiology"},{"key":"R14-7-20240808","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s007010200028","article-title":"Spinal epidural lipomatosis associated with pituitary macroprolactinoma","volume":"144","author":"Fujisawa","year":"2002","journal-title":"Acta Neurochir (Wien)"},{"key":"R16-7-20240808","doi-asserted-by":"crossref","first-page":"348","DOI":"10.3171\/jns.1996.85.2.0348","article-title":"Symptomatic epidural lipomatosis secondary to obesity. Case report","volume":"85","author":"Kumar","year":"1996","journal-title":"J Neurosurg"},{"key":"R17-7-20240808","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1043-2760(00)00236-8","article-title":"Do glucocorticoids cause spinal epidural lipomatosis? When endocrinology and spinal surgery meet","volume":"11","author":"Koch","year":"2000","journal-title":"Trends Endocrinol Metab"},{"key":"R18-7-20240808","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1001\/jama.282.16.1519","article-title":"The spread of the obesity epidemic in the United States, 1991-1998","volume":"282","author":"Mokdad","year":"1999","journal-title":"JAMA"},{"key":"R19-7-20240808","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1111\/j.1440-1797.2004.00341.x","article-title":"Effectiveness of high trough levels of cyclosporine for 5 months in a case of steroid dependent nephrotic syndrome with severe steroid toxicity","volume":"9","author":"Kano","year":"2004","journal-title":"Nephrology (Carlton)"},{"key":"R20-7-20240808","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1097\/01.PHM.0000143397.02251.56","article-title":"Epidural steroid injections in the treatment of symptomatic lumbar spinal stenosis associated with epidural lipomatosis","volume":"83","author":"Botwin","year":"2004","journal-title":"Am J Phys Med Rehabil"},{"key":"R21-7-20240808","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1007\/s007010050205","article-title":"Epidural thoracic lipomatosis induced by long-term steroid treatment case illustration","volume":"140","author":"Pinsker","year":"1998","journal-title":"Acta Neurochir (Wien)"},{"key":"R22-7-20240808","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1210\/en.2004-0037","article-title":"Minireview: glucocorticoids \u2013 food intake, abdominal obesity, and wealthy nations in 2004","volume":"145","author":"Dallman","year":"2004","journal-title":"Endocrinology"},{"key":"R23-7-20240808","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1111\/j.1399-0012.2004.00290.x","article-title":"Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma","volume":"18","author":"Resnick","year":"2004","journal-title":"Clin Transplant"},{"key":"R24-7-20240808","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1212\/WNL.39.8.1031","article-title":"Spinal epidural lipomatosis: a serious complication of iatrogenic Cushing's syndrome","volume":"39","author":"Kaplan","year":"1989","journal-title":"Neurology"},{"key":"R25-7-20240808","first-page":"494","article-title":"Repeated failure of epidural analgesia: an association with epidural fat?","volume":"25","author":"Lang","year":"2002","journal-title":"Reg Anesth Pain Med"},{"key":"R26-7-20240808","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1034\/j.1600-0404.2002.1c194.x","article-title":"A case of idiopathic spinal epidural lipomatosis presented with radicular pain caused by compression with enlarged veins surrounding nerve roots","volume":"105","author":"Kawai","year":"2002","journal-title":"Acta Neurol Scand"},{"key":"R27-7-20240808","doi-asserted-by":"crossref","first-page":"593","DOI":"10.2169\/internalmedicine.41.593","article-title":"Cauda equina syndrome caused by idiopathic sacral epidural lipomatosis","volume":"41","author":"Ohta","year":"2002","journal-title":"Intern Med"},{"key":"R28-7-20240808","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/00007632-200102010-00017","article-title":"Cauda equina syndrome secondary to idiopathic spinal epidural lipomatosis","volume":"26","author":"Lisai","year":"2001","journal-title":"Spine"},{"key":"R29-7-20240808","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1089\/109662102320135379","article-title":"Refractory neuropathic pain from chronic cord compression","volume":"5","author":"Naco","year":"2002","journal-title":"J Palliat Med"},{"key":"R30-7-20240808","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s004029900086","article-title":"A rare case of osteoporotic spine fracture associated with epidural lipomatosis causing paraplegia following long-term cortisone therapy","volume":"120","author":"Andress","year":"2000","journal-title":"Arch Orthop Trauma Surg"},{"key":"R31-7-20240808","doi-asserted-by":"crossref","first-page":"E11","DOI":"10.3171\/foc.2004.16.4.12","article-title":"Spinal epidural lipomatosis: a review of its causes and recommendations for treatment","volume":"16","author":"Fassett","year":"2004","journal-title":"Neurosurg Focus"},{"key":"R32-7-20240808","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1148\/radiology.169.2.3174998","article-title":"Epidural lipomatosis","volume":"169","author":"Quint","year":"1988","journal-title":"Radiology"},{"key":"R33-7-20240808","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1007\/s00247-002-0811-7","article-title":"Symptomatic epidural lipomatosis of the spinal cord in a child: MR demonstration of spinal cord injury","volume":"32","author":"Mu\u00f1oz","year":"2002","journal-title":"Pediatr Radiol"},{"key":"R34-7-20240808","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1007\/s00330-002-1716-4","article-title":"Lumbosacral epidural lipomatosis","volume":"13","author":"Borre","year":"2003","journal-title":"Eur Radiol"},{"key":"R35-7-20240808","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1007\/BF00593392","article-title":"Reversibility of lumbar epidural lipomatosis in obese patients after weight-reduction diet","volume":"37","author":"Borstlap","year":"1995","journal-title":"Neuroradiology"},{"key":"R36-7-20240808","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00007632-199401001-00022","article-title":"Epidural lipomatosis. Interest of magnetic resonance imaging in a weight-reduction treated case","volume":"19","author":"Beges","year":"1994","journal-title":"Spine"},{"key":"R37-7-20240808","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0090-3019(98)00016-0","article-title":"Endoscopic suction decompression of idiopathic epidural lipomatosis","volume":"50","author":"Frank","year":"1998","journal-title":"Surg Neurol"}],"container-title":["Journal of Clinical Neuromuscular Disease"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00131402-200603000-00007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:25:45Z","timestamp":1785857145000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00131402-200603000-00007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":36,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1097\/01.cnd.0000211400.12372.d3","relation":{},"ISSN":["1522-0443"],"issn-type":[{"value":"1522-0443","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}