{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,19]],"date-time":"2025-02-19T05:23:32Z","timestamp":1739942612610,"version":"3.37.3"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,1]]},"DOI":"10.1097\/01.fpc.0000236323.96056.d8","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T06:58:04Z","timestamp":1267081084000},"page":"11-24","source":"Crossref","is-referenced-by-count":12,"title":["Molecular cloning of the baboon UDP-glucuronosyltransferase 1A gene family"],"prefix":"10.1097","volume":"17","author":[{"given":"Casper S.","family":"Caspersen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Boris","family":"Reznik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piper L.","family":"Weldy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten M.","family":"Abildskov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond I.","family":"Stark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Garland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-2-20210212","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1146\/annurev.pharmtox.40.1.581","article-title":"Human UDP-glucuronosyltransferases: metabolism, expression, and disease","volume":"40","author":"Tukey","year":"2000","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R2-2-20210212","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1146\/annurev.pharmtox.44.101802.121546","article-title":"Predicting human drug glucuronidation parameters: application of in vitro and in silico modeling approaches","volume":"44","author":"Miners","year":"2004","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R3-2-20210212","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.286.5439.487","article-title":"Pharmacogenomics: translating functional genomics into rational therapeutics","volume":"286","author":"Evans","year":"1999","journal-title":"Science"},{"key":"R4-2-20210212","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/S0006-2952(03)00296-X","article-title":"Vertebrate UDP-glucuronosyltransferases: functional and evolutionary aspects","volume":"66","author":"Bock","year":"2003","journal-title":"Biochem Pharmacol"},{"key":"R5-2-20210212","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1097\/01.fpc.0000173483.13689.56","article-title":"Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily","volume":"15","author":"Mackenzie","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"R6-2-20210212","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1101\/gr.1225204","article-title":"Multiple variable first exons: a mechanism for cell- and tissue-specific gene regulation","volume":"14","author":"Zhang","year":"2004","journal-title":"Genome Res"},{"key":"R7-2-20210212","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/jb\/117.2.392","article-title":"Drug-responsive and tissue-specific alternative expression of multiple first exons in rat UDP-glucuronosyltransferase family 1 (UGT1) gene complex","volume":"117","author":"Emi","year":"1995","journal-title":"J Biochem (Tokyo)"},{"key":"R8-2-20210212","doi-asserted-by":"crossref","first-page":"3257","DOI":"10.1016\/S0021-9258(19)50724-4","article-title":"A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini","volume":"267","author":"Ritter","year":"1992","journal-title":"J Biol Chem"},{"key":"R9-2-20210212","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1097\/00008571-200106000-00011","article-title":"Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus","volume":"11","author":"Gong","year":"2001","journal-title":"Pharmacogenetics"},{"key":"R10-2-20210212","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev.pa.18.040178.000313","article-title":"Developmental aspects of drug conjugation, with special reference to glucuronidation","volume":"18","author":"Dutton","year":"1978","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"R11-2-20210212","doi-asserted-by":"crossref","first-page":"439","DOI":"10.2165\/00003088-199936060-00005","article-title":"Glucuronidation in humans. Pharmacogenetic and developmental aspects","volume":"36","author":"de Wildt","year":"1999","journal-title":"Clin Pharmacokinet"},{"key":"R12-2-20210212","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.pediatrneurol.2003.09.011","article-title":"Bilirubin toxicity in the developing nervous system","volume":"29","author":"Shapiro","year":"2003","journal-title":"Pediatr Neurol"},{"key":"R13-2-20210212","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1124\/dmd.104.001388","article-title":"The contribution of fetal metabolism to the disposition of morphine","volume":"33","author":"Garland","year":"2005","journal-title":"Drug Metab Dispos"},{"key":"R14-2-20210212","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00042560-199602010-00002","article-title":"Zidovudine kinetics in the pregnant baboon","volume":"11","author":"Garland","year":"1996","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"R15-2-20210212","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/00042560-199812150-00001","article-title":"Implications of the kinetics of zidovudine in the pregnant baboon following oral administration","volume":"19","author":"Garland","year":"1998","journal-title":"J Acquir Immune Defic Syndr Hum Retrovirol"},{"key":"R16-2-20210212","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1203\/00006450-199807000-00008","article-title":"Placental transfer and fetal metabolism of zidovudine in the baboon","volume":"44","author":"Garland","year":"1998","journal-title":"Pediatr Res"},{"key":"R17-2-20210212","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0076-6879(05)00005-4","article-title":"The role of Ah receptor in induction of human UDP-glucuronosyltransferase 1A1","volume":"400","author":"Yueh","year":"2005","journal-title":"Methods Enzymol"},{"key":"R18-2-20210212","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/0003-2697(86)90166-1","article-title":"Enhancement of immunoblot sensitivity by heating of hydrated filters","volume":"156","author":"Swerdlow","year":"1986","journal-title":"Anal Biochem"},{"key":"R19-2-20210212","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0003-2697(80)90655-7","article-title":"A unified method for the assay of uridine diphosphoglucuronyltransferase activities toward various aglycones using uridine diphospho[U-14C]glucuronic acid","volume":"109","author":"Bansal","year":"1980","journal-title":"Anal Biochem"},{"key":"R20-2-20210212","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1006\/abio.1994.1255","article-title":"Radioassay of UDP-glucuronosyltransferase activities toward endogenous substrates using labeled UDP-glucuronic acid and an organic solvent extraction procedure","volume":"219","author":"Matern","year":"1994","journal-title":"Anal Biochem"},{"key":"R21-2-20210212","doi-asserted-by":"crossref","first-page":"4876","DOI":"10.1093\/nar\/25.24.4876","article-title":"The CLUSTAL_X windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools","volume":"25","author":"Thompson","year":"1997","journal-title":"Nucleic Acids Res"},{"key":"R22-2-20210212","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1093\/bib\/5.2.150","article-title":"MEGA3: integrated software for Molecular Evolutionary Genetics Analysis and sequence alignment","volume":"5","author":"Kumar","year":"2004","journal-title":"Brief Bioinform"},{"key":"R23-2-20210212","doi-asserted-by":"crossref","first-page":"10881","DOI":"10.1093\/nar\/16.22.10881","article-title":"Multiple sequence alignment with hierarchical clustering","volume":"16","author":"Corpet","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"R24-2-20210212","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2148-4-18","article-title":"TREEFINDER: a powerful graphical analysis environment for molecular phylogenetics","volume":"4","author":"Jobb","year":"2004","journal-title":"BMC Evol Biol"},{"issue":"Web Server issue","key":"R25-2-20210212","doi-asserted-by":"crossref","first-page":"W273","DOI":"10.1093\/nar\/gkh458","article-title":"VISTA: computational tools for comparative genomics","volume":"32","author":"Frazer","year":"2004","journal-title":"Nucleic Acids Res"},{"key":"R26-2-20210212","first-page":"526","article-title":"Statistical tests for detecting gene conversion","volume":"6","author":"Sawyer","year":"1989","journal-title":"Mol Biol Evol"},{"key":"R27-2-20210212","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S0168-9525(02)02757-9","article-title":"Patterns in spontaneous mutation revealed by human-baboon sequence comparison","volume":"18","author":"Silva","year":"2002","journal-title":"Trends Genet"},{"key":"R28-2-20210212","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1124\/mol.104.007146","article-title":"Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene","volume":"67","author":"Lankisch","year":"2005","journal-title":"Mol Pharmacol"},{"key":"R29-2-20210212","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1097\/00008571-199910000-00006","article-title":"Variability at the uridine diphosphate glucuronosyltransferase 1A1 promoter in human populations and primates","volume":"9","author":"Hall","year":"1999","journal-title":"Pharmacogenetics"},{"key":"R30-2-20210212","doi-asserted-by":"crossref","first-page":"36107","DOI":"10.1074\/jbc.M305565200","article-title":"Cloning and characterization of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 gene promoters: differential regulation through an interior-like region","volume":"278","author":"Gregory","year":"2003","journal-title":"J Biol Chem"},{"key":"R31-2-20210212","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1124\/mol.65.4.953","article-title":"Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1alpha and the caudal-related homeodomain protein 2","volume":"65","author":"Gregory","year":"2004","journal-title":"Mol Pharmacol"},{"key":"R32-2-20210212","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/S0076-6879(05)00006-6","article-title":"Regulation of the human UGT1A1 gene by nuclear receptors constitutive active\/androstane receptor, pregnane\u00d7receptor, and glucocorticoid receptor","volume":"400","author":"Sugatani","year":"2005","journal-title":"Methods Enzymol"},{"key":"R33-2-20210212","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1038\/sj.tpj.6500171","article-title":"Pharmacogenomics of human UDP-glucuronosyltransferase enzymes","volume":"3","author":"Guillemette","year":"2003","journal-title":"Pharmacogenomics J"},{"key":"R34-2-20210212","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S0300-483X(02)00449-3","article-title":"Genetic polymorphisms of UDP-glucuronosyltransferases and their functional significance","volume":"181\u2013182","author":"Miners","year":"2002","journal-title":"Toxicology"},{"key":"R35-2-20210212","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1146\/annurev.genom.5.061903.180040","article-title":"Comparative primate genomics","volume":"5","author":"Enard","year":"2004","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"R36-2-20210212","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000028393","article-title":"The evolution of drug metabolism","volume":"61","author":"Nebert","year":"2000","journal-title":"Pharmacology"},{"key":"R37-2-20210212","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1101\/gr.2133704","article-title":"Gene conversion and the evolution of protocadherin gene cluster diversity","volume":"14","author":"Noonan","year":"2004","journal-title":"Genome Res"},{"key":"R38-2-20210212","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1093\/molbev\/msh041","article-title":"Concerted and nonconcerted evolution of the Hsp70 gene superfamily in two sibling species of nematodes","volume":"21","author":"Nikolaidis","year":"2004","journal-title":"Mol Biol Evol"},{"key":"R39-2-20210212","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1093\/oxfordjournals.molbev.a026047","article-title":"Detecting and characterizing gene conversions between multigene family members","volume":"16","author":"Drouin","year":"1999","journal-title":"Mol Biol Evol"},{"key":"R40-2-20210212","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1146\/annurev.genom.6.080604.162122","article-title":"Evolution of the ATP-binding cassette (ABC) transporter superfamily in vertebrates","volume":"6","author":"Dean","year":"2005","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"R41-2-20210212","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1146\/annurev.genet.36.040202.111115","article-title":"Recombination in evolutionary genomics","volume":"36","author":"Posada","year":"2002","journal-title":"Annu Rev Genet"},{"key":"R42-2-20210212","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1124\/dmd.31.1.133","article-title":"Validation of serotonin (5-hydroxtryptamine) as an in vitro substrate probe for human UDP-glucuronosyltransferase (UGT) 1A6","volume":"31","author":"Krishnaswamy","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"R43-2-20210212","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1124\/dmd.31.6.762","article-title":"The effect of incubation conditions on the enzyme kinetics of UDP-glucuronosyltransferases","volume":"31","author":"Soars","year":"2003","journal-title":"Drug Metab Dispos"},{"key":"R44-2-20210212","first-page":"507","article-title":"Glucuronidation of amines and other xenobiotics catalyzed by expressed human UDP-glucuronosyltransferase 1A3","volume":"26","author":"Green","year":"1998","journal-title":"Drug Metab Dispos"},{"key":"R45-2-20210212","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/S0022-3565(24)29222-3","article-title":"Interindividual variability in acetaminophen glucuronidation by human liver microsomes: identification of relevant acetaminophen UDP-glucuronosyltransferase isoforms","volume":"299","author":"Court","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"R46-2-20210212","doi-asserted-by":"crossref","first-page":"17960","DOI":"10.1016\/S0021-9258(17)32403-1","article-title":"Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man","volume":"269","author":"Bosma","year":"1994","journal-title":"J Biol Chem"},{"key":"R47-2-20210212","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1124\/jpet.105.091900","article-title":"Human UDP-glucuronosyltransferase 1A5: identification, expression, and activity","volume":"315","author":"Finel","year":"2005","journal-title":"J Pharmacol Exp Ther"},{"key":"R48-2-20210212","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1093\/molbev\/msg050","article-title":"Estimation of divergence times for major lineages of primate species","volume":"20","author":"Glazko","year":"2003","journal-title":"Mol Biol Evol"},{"key":"R49-2-20210212","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1006\/mpev.1998.0495","article-title":"Toward a phylogenetic classification of Primates based on DNA evidence complemented by fossil evidence","volume":"9","author":"Goodman","year":"1998","journal-title":"Mol Phylogenet Evol"},{"key":"R50-2-20210212","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/molbev\/msj093","article-title":"Genomewide search of gene conversions in duplicated genes of mouse and rat","volume":"23","author":"Ezawa","year":"2006","journal-title":"Mol Biol Evol"},{"key":"R51-2-20210212","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1038\/sj.tpj.6500351","article-title":"Comparative genomics analysis of human sequence variation in the UGT1A gene cluster","volume":"6","author":"Maitland","year":"2006","journal-title":"Pharmacogenomics J"},{"key":"R52-2-20210212","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1086\/323612","article-title":"Gene conversion and different population histories may explain the contrast between polymorphism and linkage disequilibrium levels","volume":"69","author":"Frisse","year":"2001","journal-title":"Am J Hum Genet"},{"key":"R53-2-20210212","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0960-0760(03)00235-8","article-title":"The cynomolgus monkey (Macaca fascicularis) is the best animal model for the study of steroid glucuronidation","volume":"85","author":"Barbier","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"key":"R54-2-20210212","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/0168-9525(90)90174-5","article-title":"Evolution of the P450 gene superfamily: animal\u2013plant \u2018warfare\u2019, molecular drive and human genetic differences in drug oxidation","volume":"6","author":"Gonzalez","year":"1990","journal-title":"Trends Genet"},{"key":"R55-2-20210212","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1097\/00008571-200006000-00009","article-title":"Molecular genetic basis for deficient acetaminophen glucuronidation by cats: UGT1A6 is a pseudogene, and evidence for reduced diversity of expressed hepatic UGT1A isoforms","volume":"10","author":"Court","year":"2000","journal-title":"Pharmacogenetics"},{"key":"R56-2-20210212","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1086\/515527","article-title":"Baboons as an animal model for genetic studies of common human disease","volume":"61","author":"Rogers","year":"1997","journal-title":"Am J Hum Genet"},{"key":"R57-2-20210212","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1006\/geno.2000.6245","article-title":"A genetic linkage map of the baboon (Papio hamadryas) genome based on human microsatellite polymorphisms","volume":"67","author":"Rogers","year":"2000","journal-title":"Genomics"}],"container-title":["Pharmacogenetics and Genomics"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/journals.lww.com\/01213011-200701000-00002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T21:49:53Z","timestamp":1739915393000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/01213011-200701000-00002"}},"subtitle":["Evolution of the primate UGT1 locus and relevance for models of human drug metabolism"],"short-title":[],"issued":{"date-parts":[[2007,1]]},"references-count":57,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/01.fpc.0000236323.96056.d8","relation":{},"ISSN":["1744-6872"],"issn-type":[{"type":"print","value":"1744-6872"}],"subject":[],"published":{"date-parts":[[2007,1]]}}}