{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,14]],"date-time":"2026-03-14T15:33:17Z","timestamp":1773502397377,"version":"3.50.1"},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n          <jats:p>Celiac disease is a chronic autoimmune enteropathy affecting about 1% of the population. Gluten ingestion triggers an immune response in genetically susceptible patients, resulting in intestinal and extraintestinal disease manifestations. Current recommendations for diagnosis include serology for celiac-specific antibodies to transglutaminase, endomysium, and deamidated gliadin, and IgA serology. New highly accurate point-of-care tests can efficiently screen for celiac disease and improve the diagnostic timeframe. Definitive diagnosis is most commonly made via biopsy of the small bowel showing villous atrophy. A gluten-free diet with micronutrient supplementation is the only recommended treatment for celiac disease. Primary care providers must be able to recognize screening indications, refer patients appropriately, and provide proper patient education and follow-up.<\/jats:p>","DOI":"10.1097\/01.jaa.0000824940.10046.5d","type":"journal-article","created":{"date-parts":[[2022,4,26]],"date-time":"2022-04-26T17:03:37Z","timestamp":1650992617000},"page":"39-44","update-policy":"https:\/\/doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":4,"title":["Updates on the diagnosis and management of celiac disease"],"prefix":"10.1097","volume":"35","author":[{"given":"Kristina","family":"Soltesz","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jessica","family":"Mosebach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emily","family":"Paruch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean","family":"Covino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"issue":"5","key":"R1-20250607","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1038\/ajg.2013.79","article-title":"ACG clinical guidelines: diagnosis and management of celiac disease","volume":"108","author":"Rubio-Tapia","year":"2013","journal-title":"Am J Gastroenterol"},{"issue":"6","key":"R2-20250607","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1053\/j.gastro.2009.09.008","article-title":"Celiac disease: from pathogenesis to novel therapies","volume":"137","author":"Schuppan","year":"2009","journal-title":"Gastroenterology"},{"issue":"23","key":"R3-20250607","doi-asserted-by":"crossref","first-page":"7110","DOI":"10.3748\/wjg.v21.i23.7110","article-title":"Diagnosis of gluten related disorders: Celiac disease, wheat allergy and non-celiac gluten sensitivity","volume":"21","author":"Elli","year":"2015","journal-title":"World J Gastroenterol"},{"issue":"7","key":"R4-20250607","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.mayocp.2018.11.036","article-title":"Micronutrient deficiencies are common in contemporary celiac disease despite lack of overt malabsorption symptoms","volume":"94","author":"Bledsoe","year":"2019","journal-title":"Mayo Clin Proc"},{"issue":"1","key":"R5-20250607","first-page":"38","article-title":"Serologic testing in celiac disease: practical guide for clinicians","volume":"62","author":"Rashid","year":"2016","journal-title":"Can Fam Physician"},{"issue":"1","key":"R6-20250607","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/MCG.0000000000000962","article-title":"Diagnostic yield of 2 strategies for adult celiac disease identification in primary care","volume":"53","author":"Scoglio","year":"2019","journal-title":"J Clin Gastroenterol"},{"issue":"4","key":"R7-20250607","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1053\/j.gastro.2018.12.010","article-title":"AGA clinical practice update on diagnosis and monitoring of celiac disease\u2014changing utility of serology and histologic measures: expert review","volume":"156","author":"Husby","year":"2019","journal-title":"Gastroenterology"},{"issue":"11","key":"R8-20250607","first-page":"726","article-title":"Comparative accuracy of diagnostic tests for celiac disease","volume":"95","author":"Seehusen","year":"2017","journal-title":"Am Fam Physician"},{"issue":"8","key":"R9-20250607","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1515\/cclm-2019-0088","article-title":"Diagnostic accuracy of a fully automated multiplex celiac disease antibody panel for serum and plasma","volume":"57","author":"Terryberry","year":"2019","journal-title":"Clin Chem Lab Med"},{"issue":"4","key":"R10-20250607","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1053\/j.gastro.2005.02.010","article-title":"Clinical features and diagnosis of celiac disease","volume":"128","author":"Dewar","year":"2005","journal-title":"Gastroenterology"},{"key":"R11-20250607","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.coph.2015.09.002","article-title":"Pharmacological approaches in celiac disease","volume":"25","author":"McCarville","year":"2015","journal-title":"Curr Opin Pharmacol"},{"key":"R12-20250607","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpeds.2019.09.071","article-title":"A celiac care index improves care of pediatric patients newly diagnosed with celiac disease","volume":"216","author":"Sparks","year":"2020","journal-title":"J Pediatr"}],"container-title":["JAAPA"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/01.JAA.0000824940.10046.5d","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,7]],"date-time":"2025-06-07T19:00:36Z","timestamp":1749322836000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/01.JAA.0000824940.10046.5d"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022]]}},"URL":"https:\/\/doi.org\/10.1097\/01.jaa.0000824940.10046.5d","relation":{},"ISSN":["1547-1896"],"issn-type":[{"value":"1547-1896","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]}}}