{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T06:52:07Z","timestamp":1790232727098,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,3,1]],"date-time":"2003-03-01T00:00:00Z","timestamp":1046476800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7256,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2003,3]]},"DOI":"10.1097\/01.lab.0000059926.66359.bd","type":"journal-article","created":{"date-parts":[[2013,9,4]],"date-time":"2013-09-04T18:29:08Z","timestamp":1378319348000},"page":"429-434","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":118,"title":["Overexpression of Human Dickkopf-1, an Antagonist of wingless\/WNT Signaling, in Human Hepatoblastomas and Wilms' Tumors"],"prefix":"10.1016","volume":"83","author":[{"given":"Oliver","family":"Wirths","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Waha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sascha","family":"Weggen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Schirmacher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"K\u00fchne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia G","family":"Goodyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steffen","family":"Albrecht","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dietrich","family":"von Schweinitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torsten","family":"Pietsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib1","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1038\/282615a0","article-title":"Controlled synthesis of HBsAg in a differentiated human liver carcinoma-derived cell line","volume":"282","author":"Aden","year":"1979","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib2","first-page":"5041","article-title":"Loss of maternal alleles on chromosome arm 11p in hepatoblastoma","volume":"54","author":"Albrecht","year":"1994","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib3","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/35000501","article-title":"Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling","volume":"403","author":"Alizadeh","year":"2000","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib4","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1038\/35083081","article-title":"Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6\/Arrow","volume":"3","author":"Bafico","year":"2001","journal-title":"Nat Cell Biol"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib5","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1016\/0016-5085(94)90024-8","article-title":"Overexpression of glutamine synthetase in human primary liver cancer","volume":"106","author":"Christa","year":"1994","journal-title":"Gastroenterology"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib6","doi-asserted-by":"crossref","first-page":"8847","DOI":"10.1073\/pnas.95.15.8847","article-title":"Somatic mutations of the beta-catenin gene are frequent in mouse and human hepatocellular carcinomas","volume":"95","author":"de La Coste","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib7","doi-asserted-by":"crossref","first-page":"6025","DOI":"10.1073\/pnas.93.12.6025","article-title":"Suppression subtractive hybridization: A method for generating differentially regulated or tissue-specific cDNA probes and libraries","volume":"93","author":"Diatchenko","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib8","first-page":"1","article-title":"Establishment of a cell line and its clonal sublines from a patient with hepatoblastoma","volume":"67","author":"Doi","year":"1976","journal-title":"Gann"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib9","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/34848","article-title":"Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction","volume":"391","author":"Glinka","year":"1998","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib10","first-page":"269","article-title":"Childhood hepatoblastomas frequently carry a mutated degradation targeting box of the beta-catenin gene","volume":"59","author":"Koch","year":"1999","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1002\/(SICI)1097-0215(19960807)67:4<467::AID-IJC1>3.0.CO;2-Q","article-title":"Loss of heterozygosity on chromosome 1 in human hepatoblastoma","volume":"67","author":"Kraus","year":"1996","journal-title":"Int J Cancer"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib12","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0378-1119(99)00365-0","article-title":"Functional and structural diversity of the human Dickkopf gene family","volume":"238","author":"Krupnik","year":"1999","journal-title":"Gene"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib13","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1128\/MCB.22.4.1184-1193.2002","article-title":"Negative feedback loop of Wnt signaling through upregulation of conductin\/axin2 in colorectal and liver tumors","volume":"22","author":"Lustig","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib14","first-page":"6288","article-title":"Frequent association of beta-catenin and WT1 mutations in Wilms' tumors","volume":"60","author":"Maiti","year":"2000","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1111\/j.1365-3016.1990.tb00651.x","article-title":"Malignant hepatic tumours in children: Incidence, clinical features and aetiology","volume":"4","author":"Mann","year":"1990","journal-title":"Paediatr Perinat Epidemiol"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib16","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1038\/nature756","article-title":"Kremen proteins are Dickkopf receptors that regulate Wnt\/beta-catenin signalling","volume":"417","author":"Mao","year":"2002","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib17","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/35077108","article-title":"LDL-receptor-related protein 6 is a receptor for Dickkopf proteins","volume":"411","author":"Mao","year":"2001","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib18","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0925-4773(99)00138-0","article-title":"Dickkopf genes are co-ordinately expressed in mesodermal lineages","volume":"87","author":"Monaghan","year":"1999","journal-title":"Mech Dev"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib19","first-page":"3320","article-title":"Somatic mutations of the APC gene in sporadic hepatoblastomas","volume":"56","author":"Oda","year":"1996","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib20","first-page":"809","article-title":"Characterization of the continuous cell line HepT1 derived from a human hepatoblastoma","volume":"74","author":"Pietsch","year":"1996","journal-title":"Lab Invest"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib21","first-page":"3278","article-title":"Characterization of five new cell lines derived from human primitive neuroectodermal tumors of the central nervous system","volume":"54","author":"Pietsch","year":"1994","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib22","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1101\/gad.14.15.1837","article-title":"Wnt signaling and cancer","volume":"14","author":"Polakis","year":"2000","journal-title":"Genes Dev"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib23","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1159\/000015618","article-title":"The genomic structure, chromosome location, and analysis of the human DKK1 head inducer gene as a candidate for holoprosencephaly","volume":"89","author":"Roessler","year":"2000","journal-title":"Cytogenet Cell Genet"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib24","author":"Sambrook","year":"1989","journal-title":"Molecular cloning: A laboratory manual"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib25","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0960-9822(01)00290-1","article-title":"Head inducer Dickkopf-1 is a ligand for Wnt coreceptor LRP6","volume":"11","author":"Semenov","year":"2001","journal-title":"Curr Biol"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib26","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/sj.onc.1205138","article-title":"Human Dkk-1, a gene encoding a Wnt antagonist, responds to DNA damage and its overexpression sensitizes brain tumor cells to apoptosis following alkylation damage of DNA","volume":"21","author":"Shou","year":"2002","journal-title":"Oncogene"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib27","doi-asserted-by":"crossref","first-page":"4863","DOI":"10.1038\/sj.onc.1205591","article-title":"Mutational spectrum of beta-catenin, AXIN1, and AXIN2 in hepatocellular carcinomas and hepatoblastomas","volume":"21","author":"Taniguchi","year":"2002","journal-title":"Oncogene"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib28","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1038\/sj.onc.1203503","article-title":"Dickkopf-1, an inhibitor of the Wnt signaling pathway, is induced by p53","volume":"19","author":"Wang","year":"2000","journal-title":"Oncogene"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib29","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0002-9440(10)64567-1","article-title":"Characterization of genomic alterations in hepatoblastomas: A role for gains on chromosomes 8q and 20 as predictors of poor outcome","volume":"157","author":"Weber","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1097\/01.LAB.0000059926.66359.BD_bib30","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1016\/S0960-9822(00)00868-X","article-title":"Mutual antagonism between dickkopf1 and dickkopf2 regulates Wnt\/beta-catenin signalling","volume":"10","author":"Wu","year":"2000","journal-title":"Curr Biol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372203570X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372203570X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T13:31:30Z","timestamp":1675949490000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372203570X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,3]]}},"alternative-id":["S002368372203570X"],"URL":"https:\/\/doi.org\/10.1097\/01.lab.0000059926.66359.bd","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2003,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overexpression of Human Dickkopf-1, an Antagonist of wingless\/WNT Signaling, in Human Hepatoblastomas and Wilms' Tumors","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/01.LAB.0000059926.66359.BD","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}