{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T23:12:12Z","timestamp":1774566732411,"version":"3.50.1"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2003,9,1]],"date-time":"2003-09-01T00:00:00Z","timestamp":1062374400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7072,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2003,9]]},"DOI":"10.1097\/01.lab.0000087586.25982.b5","type":"journal-article","created":{"date-parts":[[2003,9,17]],"date-time":"2003-09-17T22:23:12Z","timestamp":1063837392000},"page":"1285-1291","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":36,"title":["Morphometric Analysis of Mouse Airways After Chronic Allergen Challenge"],"prefix":"10.1016","volume":"83","author":[{"given":"Russ","family":"Ellis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Leigh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Southam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul M","family":"O'Byrne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark D","family":"Inman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib1","doi-asserted-by":"crossref","first-page":"93S","DOI":"10.1378\/chest.107.3_Supplement.93S","article-title":"Chronic allergic inflammation induces replication of airway smooth muscle cells in vivo in guinea pigs","volume":"107","author":"Bai","year":"1995","journal-title":"Chest"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib2","doi-asserted-by":"crossref","first-page":"5219","DOI":"10.4049\/jimmunol.166.8.5219","article-title":"Therapeutic effect of IL-13 immunoneutralization during chronic experimental fungal asthma","volume":"166","author":"Blease","year":"2001","journal-title":"J Immunol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0002-9440(10)64867-5","article-title":"Stat6-deficient mice develop airway hyperresponsiveness and peribronchial fibrosis during chronic fungal asthma","volume":"160","author":"Blease","year":"2002","journal-title":"Am J Pathol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1378\/chest.112.1.45","article-title":"Bronchial subepithelial fibrosis correlates with airway responsiveness to methacholine","volume":"112","author":"Boulet","year":"1997","journal-title":"Chest"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib5","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1164\/ajrccm.162.4.9910051","article-title":"Airway hyperresponsiveness, inflammation, and subepithelial collagen deposition in recently diagnosed versus long-standing mild asthma: Influence of inhaled corticosteroids","volume":"162","author":"Boulet","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib6","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1164\/ajrccm\/147.2.405","article-title":"The structure of the large and small airways in nonfatal and fatal asthma","volume":"147","author":"Carroll","year":"1993","journal-title":"Am Rev Respir Dis"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib7","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1378\/chest.111.4.852","article-title":"Airways remodeling is a distinctive feature of asthma and is related to severity of disease","volume":"111","author":"Chetta","year":"1997","journal-title":"Chest"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib8","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1164\/ajrccm.153.3.8630572","article-title":"Bronchial responsiveness to distilled water and methacholine and its relationship to inflammation and remodeling of the airways in asthma","volume":"153","author":"Chetta","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib9","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1183\/09031936.01.17405810","article-title":"The reproducibility and sample size requirements of exercise-induced bronchoconstriction measurements","volume":"17","author":"Dahlen","year":"2001","journal-title":"Eur Respir J"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/jcp.13.1.27","article-title":"The pathology of asthma with special reference to changes in the bronchial mucosa","volume":"13","author":"Dunnil","year":"1960","journal-title":"J Clin Pathol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib11","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/ajrccm.165.1.2105051","article-title":"A role for cysteinyl leukotrienes in airway remodeling in a mouse asthma model","volume":"165","author":"Henderson","year":"2002","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1165\/ajrcmb.21.4.3622","article-title":"Allergen-induced increase in airway responsiveness, airway eosinophilia and bone marrow eosinophil progenitors in mice","volume":"21","author":"Inman","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib13","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1164\/ajrccm\/145.4_Pt_1.890","article-title":"Effects of treatment on airway inflammation and thickening of basement membrane reticular collagen in asthma: A quantitative light and electron microscopic study","volume":"145","author":"Jeffery","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib14","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1164\/ajrccm\/140.6.1745","article-title":"Bronchial biopsies in asthma: An ultrastructural, quantitative study and correlation with hyperreactivity","volume":"140","author":"Jeffery","year":"1989","journal-title":"Am Rev Respir Dis"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib15","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1084\/jem.194.6.809","article-title":"Interleukin-13 induces tissue fibrosis by selectively stimulating and activating transforming growth factor beta(1)","volume":"194","author":"Lee","year":"2001","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib16","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1165\/rcmb.2002-0048OC","article-title":"Dysfunction and remodeling of the mouse airway persist after resolution of acute allergen-induced airway inflammation","volume":"27","author":"Leigh","year":"2002","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib17","doi-asserted-by":"crossref","first-page":"L148","DOI":"10.1152\/ajplung.00105.2002","article-title":"Repeated allergen inhalation induces phenotypic modulation of smooth muscle in bronchioles of sensitized rats","volume":"284","author":"Moir","year":"2003","journal-title":"American J Physiol Lung Cell Mol Physiol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1165\/ajrcmb.16.5.9160833","article-title":"Cytokine and eosinophil responses in the lung, peripheral blood, and bone marrow compartments in a murine model of allergen-induced airways inflammation","volume":"16","author":"Ohkawara","year":"1997","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib19","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1164\/ajrccm.161.2.9902094","article-title":"Prolonged allergen exposure induces structural airway changes in sensitized rats","volume":"161","author":"Palmans","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib20","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/S0140-6736(89)90067-6","article-title":"Subepithelial fibrosis in the bronchi of asthmatics","volume":"1","author":"Roche","year":"1989","journal-title":"Lancet"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib21","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1034\/j.1399-3003.1999.14c25.x","article-title":"Repeated allergen exposure of sensitized Brown-Norway rats induces airway cell DNA synthesis and remodelling","volume":"14","author":"Salmon","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib22","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1172\/JCI119590","article-title":"Adenovector-mediated gene transfer of active transforming growth factor-beta1 induces prolonged severe fibrosis in rat lung","volume":"100","author":"Sime","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib23","doi-asserted-by":"crossref","first-page":"L833","DOI":"10.1152\/ajplung.00173.2001","article-title":"Distribution of intranasal instillations in mice: Effects of volume, time, body position, and anesthesia","volume":"282","author":"Southam","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib24","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1136\/thx.53.10.849","article-title":"An improved murine model of asthma: Selective airway inflammation, epithelial lesions and increased methacholine responsiveness following chronic exposure to aerosolized allergen","volume":"53","author":"Temelkovski","year":"1998","journal-title":"Thorax"},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib25","unstructured":"Washington DCUSGPO (1985). Guide for the Care and Use of Laboratory Animals. National Institutes of Health Publication No. 86-23. Washington DC: U.S. Government Printing Office."},{"key":"10.1097\/01.LAB.0000087586.25982.B5_bib26","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/ar.a.10172","article-title":"Morphology of aging lung in F344\/N rat: Alveolar size, connective tissue, and smooth muscle cell markers","volume":"272A","author":"Yamamoto","year":"2003","journal-title":"Anat Rec"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722034808?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722034808?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T13:24:40Z","timestamp":1675949080000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722034808"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,9]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2003,9]]}},"alternative-id":["S0023683722034808"],"URL":"https:\/\/doi.org\/10.1097\/01.lab.0000087586.25982.b5","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2003,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Morphometric Analysis of Mouse Airways After Chronic Allergen Challenge","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/01.LAB.0000087586.25982.B5","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}