{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:11:47Z","timestamp":1790856707185,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":7042,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1097\/01.lab.0000090158.68852.d1","type":"journal-article","created":{"date-parts":[[2003,10,16]],"date-time":"2003-10-16T20:04:18Z","timestamp":1066334658000},"page":"1457-1466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":92,"title":["Pattern of Recruitment of Immunoregulatory Antigen-Presenting Cells in Malignant Melanoma"],"prefix":"10.1016","volume":"83","author":[{"given":"Jeffrey R","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rory R","family":"Dalton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane L","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhav D","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M","family":"Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell E","family":"Burgess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fermina","family":"Mazzella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott J","family":"Antonia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew L","family":"Mellor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David H","family":"Munn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib1","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/ni722","article-title":"Dendritic cell maturation is required for the cross-tolerization of CD8+ T cells","volume":"2","author":"Albert","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib2","doi-asserted-by":"crossref","first-page":"3635","DOI":"10.1200\/JCO.2001.19.16.3635","article-title":"Final version of the American Joint Committee on Cancer staging system for cutaneous melanoma","volume":"19","author":"Balch","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib3","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1084\/jem.190.11.1717","article-title":"Coupling and uncoupling of tumor immunity and autoimmunity","volume":"190","author":"Bowne","year":"1999","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib4","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/modpathol.3880358","article-title":"Sentinel lymph nodes show profound downregulation of antigen-presenting cells of the paracortex: Implications for tumor biology and treatment","volume":"14","author":"Cochran","year":"2001","journal-title":"Mod Pathol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1089\/107999001750277916","article-title":"Human primary CD4+ T cells activated in the presence of IFN-\u03b12b express functional indoleamine 2, 3-dioxygenase","volume":"21","author":"Curreli","year":"2001","journal-title":"J Interferon Cytokine Res"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib6","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1084\/jem.193.2.233","article-title":"Antigen-specific inhibition of effector T cell function in humans after injection of immature dendritic cells","volume":"193","author":"Dhodapkar","year":"2001","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib7","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1084\/jem.188.2.373","article-title":"Selective recruitment of immature and mature dendritic cells by distinct chemokines expressed in different anatomic sites","volume":"188","author":"Dieu","year":"1998","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib8","first-page":"2810","article-title":"Peripheral tolerance to human papillomavirus E7 oncoprotein occurs by cross-tolerization, is largely Th-2-independent, and is broken by dendritic cell immunization","volume":"60","author":"Doan","year":"2000","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib9","doi-asserted-by":"crossref","first-page":"708","DOI":"10.4049\/jimmunol.167.2.708","article-title":"IL-6 inhibits the tolerogenic function of CD8alpha(+) dendritic cells expressing indoleamine 2, 3-dioxygenase","volume":"167","author":"Grohmann","year":"2001","journal-title":"J Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib10","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1038\/ni846","article-title":"CTLA-4-Ig regulates tryptophan catabolism in vivo","volume":"3","author":"Grohmann","year":"2002","journal-title":"Nat Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib11","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/S0952-7915(00)00195-3","article-title":"Immunity against cancer: Lessons learned from melanoma","volume":"13","author":"Houghton","year":"2001","journal-title":"Curr Opin Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib12","doi-asserted-by":"crossref","first-page":"3596","DOI":"10.4049\/jimmunol.164.7.3596","article-title":"Indoleamine 2, 3-dioxygenase production by human dendritic cells results in the inhibition of T cell proliferation","volume":"164","author":"Hwu","year":"2000","journal-title":"J Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib13","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1084\/jem.191.8.1381","article-title":"Localization of distinct Peyer's patch dendritic cell subsets and their recruitment by chemokines macrophage inflammatory protein (MIP)-3alpha, MIP-3beta, and secondary lymphoid organ chemokine","volume":"191","author":"Iwasaki","year":"2000","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib14","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/eji.1830271209","article-title":"Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions","volume":"27","author":"Jonuleit","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib15","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1084\/jem.192.9.1213","article-title":"Induction of interleukin 10-producing, nonproliferating CD4(+) T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells","volume":"192","author":"Jonuleit","year":"2000","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib16","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/S1471-4906(01)01952-4","article-title":"Dendritic cells as a tool to induce anergic and regulatory T cells","volume":"22","author":"Jonuleit","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib17","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1084\/jem.191.10.1699","article-title":"Comparative analysis of genetically modified dendritic cells and tumor cells as therapeutic cancer vaccines","volume":"191","author":"Klein","year":"2000","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.4049\/jimmunol.162.1.186","article-title":"CC-chemokine receptor 6 is expressed on diverse memory subsets of T cells and determines responsiveness to macrophage inflammatory protein 3\u03b1","volume":"162","author":"Liao","year":"1999","journal-title":"J Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib19","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0092-8674(01)00456-1","article-title":"Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity","volume":"106","author":"Liu","year":"2001","journal-title":"Cell"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib20","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.4049\/jimmunol.168.8.3771","article-title":"Cells expressing indoleamine 2, 3-dioxygenase inhibit T cell responses","volume":"168","author":"Mellor","year":"2002","journal-title":"J Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib21","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20011341","article-title":"Repetitive injection of dendritic cells matured with tumor necrosis factor \u03b1 induce antigen-specific protection of mice from autoimmunity","volume":"195","author":"Menges","year":"2002","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib22","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1084\/jem.189.9.1363","article-title":"Inhibition of T cell proliferation by macrophage tryptophan catabolism","volume":"189","author":"Munn","year":"1999","journal-title":"J Exp Med"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib23","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1126\/science.1073514","article-title":"Potential regulatory function of human dendritic cells expressing indoleamime 2, 3-dioxyenase","volume":"297","author":"Munn","year":"2002","journal-title":"Science"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib24","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1126\/science.281.5380.1191","article-title":"Prevention of allogeneic fetal rejection by tryptophan catabolism","volume":"281","author":"Munn","year":"1998","journal-title":"Science"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib25","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1038\/35082583","article-title":"Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction","volume":"411","author":"Ochsenbein","year":"2001","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib26","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1038\/35082676","article-title":"T cells and tumours","volume":"411","author":"Pardoll","year":"2001","journal-title":"Nature"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib27","first-page":"2618","article-title":"Enhancement of tumor lysate- and peptide-pulsed dendritic cell-based vaccines by the addition of foreign helper protein","volume":"61","author":"Shimizu","year":"2001","journal-title":"Cancer Res"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib28","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/86297","article-title":"A fresh look at tumor immunosurveillance and immunotherapy","volume":"2","author":"Smyth","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib29","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1182\/blood.V98.4.1070","article-title":"Cross-presentation of tumor antigens by bone marrow-derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression","volume":"98","author":"Sotomayor","year":"2001","journal-title":"Blood"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib30","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1073\/pnas.95.3.1178","article-title":"Induction of antigen-specific T cell anergy: An early event in the course of tumor progression","volume":"95","author":"Staveley-O'Carroll","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1073\/pnas.231606698","article-title":"Avoiding horror autotoxicus: The importance of dendritic cells in peripheral T cell tolerance","volume":"99","author":"Steinman","year":"2002","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1097\/01.LAB.0000090158.68852.D1_bib32","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1172\/JCI11297","article-title":"CCR6-deficient mice have impaired leukocyte homeostasis and altered contact hypersensitivity and delayed-type hypersensitivity responses","volume":"107","author":"Varona","year":"2001","journal-title":"J Clin Invest"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722034687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683722034687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T13:23:01Z","timestamp":1675948981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683722034687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":32,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0023683722034687"],"URL":"https:\/\/doi.org\/10.1097\/01.lab.0000090158.68852.d1","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pattern of Recruitment of Immunoregulatory Antigen-Presenting Cells in Malignant Melanoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/01.LAB.0000090158.68852.D1","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}