{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:59:31Z","timestamp":1785859171072,"version":"3.56.0"},"reference-count":80,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Current Opinion in Pulmonary Medicine"],"published-print":{"date-parts":[[2006,1]]},"DOI":"10.1097\/01.mcp.0000199810.42011.8e","type":"journal-article","created":{"date-parts":[[2005,12,15]],"date-time":"2005-12-15T04:02:27Z","timestamp":1134619347000},"page":"34-41","source":"Crossref","is-referenced-by-count":14,"title":["Asthma therapy for children under 5 years of age"],"prefix":"10.1097","volume":"12","author":[{"given":"Annemie LM","family":"Boehmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter JFM","family":"Merkus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8","first-page":"307","author":"Silverman","year":"2002"},{"key":"R3-8-20090923","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1164\/rccm.200504-525OC","volume":"172","author":"Morgan","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R4-8","first-page":"55","author":"Martinez","year":"2003"},{"key":"R5-8-20090923","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.prrv.2004.01.007","volume":"5","author":"Stein","year":"2004","journal-title":"Paediatr Respir Rev"},{"key":"R6-8-20090923","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1067\/mai.2001.118789","volume":"108","author":"Roorda","year":"2001","journal-title":"J Allergy Clin Immunol"},{"key":"R7-8-20090923","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1002\/ppul.1950180305","volume":"18","author":"Kanengiser","year":"1994","journal-title":"Pediatr Pulmonol"},{"issue":"4 Pt 1","key":"R8-8-20090923","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","volume":"162","author":"Castro-Rodriguez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R9-8-20090923","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1111\/j.1365-2222.1997.tb01246.x","volume":"27","author":"Hogg","year":"1997","journal-title":"Clin Exp Allergy"},{"key":"R11-8-20090923","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1136\/adc.88.12.1086","volume":"88","author":"Hofhuis","year":"2003","journal-title":"Arch Dis Child"},{"key":"R12-8-20090923","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1136\/bmj.331.7513.373","volume":"331","author":"Tappin","year":"2005","journal-title":"BMJ"},{"key":"R13-8-20090923","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1067\/mpd.2001.117006","volume":"139","author":"Gdalevich","year":"2001","journal-title":"J Pediatr"},{"issue":"3","key":"R14-8-20090923","first-page":"CD002873","volume":"&NA;","author":"Chavasse","year":"2002","journal-title":"Cochrane Database Syst Rev"},{"key":"R15-8-20090923","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1164\/ajrccm\/144.2.347","volume":"144","author":"Kraemer","year":"1991","journal-title":"Am Rev Respir Dis"},{"key":"R16-8-20090923","first-page":"412","volume":"146","author":"Alario","year":"1992","journal-title":"Am J Dis Child"},{"key":"R17-8-20090923","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1542\/peds.89.1.133","volume":"89","author":"Bentur","year":"1992","journal-title":"Pediatrics"},{"key":"R18-8-20090923","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/ppul.1950100108","volume":"10","author":"Sly","year":"1991","journal-title":"Pediatr Pulmonol"},{"key":"R19-8-20090923","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1136\/adc.69.1.125","volume":"69","author":"Clarke","year":"1993","journal-title":"Arch Dis Child"},{"key":"R20-8-20090923","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1002\/(SICI)1099-0496(199807)26:1<35::AID-PPUL7>3.0.CO;2-H","volume":"26","author":"Hayden","year":"1998","journal-title":"Pediatr Pulmonol"},{"key":"R21-8-20090923","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1136\/adc.82.5.370","volume":"82","author":"Chavasse","year":"2000","journal-title":"Arch Dis Child"},{"key":"R22-8-20090923","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/S0140-6736(86)92735-2","volume":"2","author":"O\u02bcCallaghan","year":"1986","journal-title":"Lancet"},{"key":"R23-8-20090923","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1136\/thx.42.2.86","volume":"42","author":"Prendiville","year":"1987","journal-title":"Thorax"},{"key":"R24-8-20090923","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1136\/adc.88.3.246","volume":"88","author":"Hofhuis","year":"2003","journal-title":"Arch Dis Child"},{"key":"R25-8-20090923","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1164\/ajrccm.160.4.9709004","volume":"160","author":"Tiddens","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"R26-8-20090923","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1111\/j.1399-3038.2004.00147.x","volume":"15","author":"Lodrup Carlsen","year":"2004","journal-title":"Pediatr Allergy Immunol"},{"key":"R27-8-20090923","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1164\/rccm.200408-1088OC","volume":"171","author":"Teper","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R28-8-20090923","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1164\/rccm.200410-1404OC","volume":"171","author":"Saglani","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R29-8-20090923","first-page":"266","volume":"366","year":"2005","journal-title":"Lancet"},{"key":"R30-8-20090923","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1081\/JAS-120033986","volume":"41","author":"Sekhsaria","year":"2004","journal-title":"J Asthma"},{"issue":"3","key":"R31-8-20090923","first-page":"CD003535","volume":"&NA;","author":"McDonald","year":"2003","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"R32-8-20090923","first-page":"CD001279","volume":"&NA;","author":"Everard","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"R33-8-20090923","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1398-9995.1999.tb04392.x","volume":"54","author":"Haahtela","year":"1999","journal-title":"Allergy"},{"key":"R34-8-20090923","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1111\/j.1398-9995.2004.00504.x","volume":"59","author":"Rytila","year":"2004","journal-title":"Allergy"},{"key":"R35-8-20090923","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1164\/ajrccm\/146.3.547","volume":"146","author":"van Essen-Zandvliet","year":"1992","journal-title":"Am Rev Respir Dis"},{"key":"R36-8-20090923","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1183\/09031936.04.00031504","volume":"23","author":"Merkus","year":"2004","journal-title":"Eur Respir J"},{"key":"R37-8-20090923","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1136\/adc.72.4.317","volume":"72","author":"Wilson","year":"1995","journal-title":"Arch Dis Child"},{"key":"R38-8-20090923","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1136\/bmj.315.7112.858","volume":"315","author":"Doull","year":"1997","journal-title":"BMJ"},{"issue":"10 Pt 1","key":"R39-8-20090923","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1164\/ajrccm.164.10.2102118","volume":"164","author":"Grunberg","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"R40-8-20090923","first-page":"CD001107","volume":"&NA;","author":"McKean","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"R41-8-20090923","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1136\/adc.65.4.407","volume":"65","author":"Wilson","year":"1990","journal-title":"Arch Dis Child"},{"key":"R42-8-20090923","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1651-2227.1999.tb01266.x","volume":"88","author":"Svedmyr","year":"1999","journal-title":"Acta Paediatr"},{"key":"R43-8-20090923","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1002\/ppul.1950020106","volume":"2","author":"Maayan","year":"1986","journal-title":"Pediatr Pulmonol"},{"key":"R44-8-20090923","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/0140-6736(90)92147-A","volume":"336","author":"Bisgaard","year":"1990","journal-title":"Lancet"},{"key":"R45-8-20090923","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1136\/adc.67.3.285","volume":"67","author":"Noble","year":"1992","journal-title":"Arch Dis Child"},{"key":"R46-8-20090923","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/adc.69.3.351","volume":"69","author":"Connett","year":"1993","journal-title":"Arch Dis Child"},{"key":"R47-8-20090923","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1159\/000196702","volume":"64","author":"Kraemer","year":"1997","journal-title":"Respiration"},{"key":"R48-8-20090923","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1164\/ajrccm.160.1.9811024","volume":"160","author":"Bisgaard","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"R49-8-20090923","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1542\/peds.113.2.e87","volume":"113","author":"Bisgaard","year":"2004","journal-title":"Pediatrics"},{"key":"R50-8-20090923","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1002\/ppul.10400","volume":"37","author":"Teper","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"R51-8-20090923","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1002\/ppul.1950090310","volume":"9","author":"Van Bever","year":"1990","journal-title":"Pediatr Pulmonol"},{"key":"R52-8-20090923","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1136\/adc.73.4.327","volume":"73","author":"Stick","year":"1995","journal-title":"Arch Dis Child"},{"key":"R53-8-20090923","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1002\/ppul.10115","volume":"34","author":"Barrueto","year":"2002","journal-title":"Pediatr Pulmonol"},{"key":"R54-8-20090923","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/ppul.20055","volume":"38","author":"Moeller","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"R55-8-20090923","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1164\/rccm.200402-227OC","volume":"171","author":"Hofhuis","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R56-8-20090923","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1164\/ajrccm.172.8.956","volume":"172","author":"Merkus","year":"2005","journal-title":"Am J Crit Care Med"},{"key":"R57-8-20090923","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1152\/japplphysiol.00486.2004","volume":"98","author":"Kovar","year":"2005","journal-title":"J Appl Physiol"},{"key":"R58-8-20090923","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1183\/09031936.01.17202870","volume":"17","author":"Brand","year":"2001","journal-title":"Eur Respir J"},{"key":"R60-8-20090923","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1002\/ppul.2001","volume":"21","author":"Jeffery","year":"2001","journal-title":"Pediatr Pulmonol Suppl"},{"key":"R61-8-20090923","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1164\/rccm.2501001","volume":"171","author":"Szefler","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"issue":"4 Pt 1","key":"R62-8-20090923","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1164\/ajrccm.159.4.9806052","volume":"159","author":"Sont","year":"1999","journal-title":"Am J Respir Crit Care Med"},{"key":"R63-8-20090923","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1016\/j.rmed.2004.11.011","volume":"99","author":"van den Toorn","year":"2005","journal-title":"Respir Med"},{"key":"R64-8-20090923","first-page":"1s","volume":"27","author":"Pedersen","year":"1998","journal-title":"Eur Respir J Suppl"},{"key":"R65-8-20090923","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.jaci.2005.07.011","volume":"116","author":"Pascual","year":"2005","journal-title":"J Allergy Clin Immunol"},{"key":"R66-8-20090923","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200205-414OC","volume":"167","author":"Payne","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"R67-8-20090923","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1399-3038.2005.00239.x","volume":"16","author":"Pohunek","year":"2005","journal-title":"Pediatr Allergy Immunol"},{"key":"R68-8-20090923","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1164\/rccm.200411-1498OC","volume":"172","author":"Smith","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R69-8-20090923","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1183\/09031936.05.00079604","volume":"25","author":"Brussee","year":"2005","journal-title":"Eur Respir J"},{"key":"R70-8-20090923","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1034\/j.1399-3038.2000.00093.x","volume":"11","author":"Ratjen","year":"2000","journal-title":"Pediatr Allergy Immunol"},{"key":"R71-8-20090923","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00130832-200304000-00007","volume":"3","author":"Payne","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R72-8-20090923","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1164\/rccm.200503-458OC","volume":"172","author":"Pijnenburg","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R73-8-20090923","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1183\/09031936.05.00031904","volume":"25","author":"Straub","year":"2005","journal-title":"Eur Respir J"},{"issue":"6 Pt 1","key":"R74-8-20090923","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/S0091-6749(97)80007-3","volume":"99","author":"Koller","year":"1997","journal-title":"J Allergy Clin Immunol"},{"key":"R75-8-20090923","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1136\/adc.61.1.15","volume":"61","author":"Webb","year":"1986","journal-title":"Arch Dis Child"},{"key":"R76-8-20090923","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1111\/j.1651-2227.1993.tb12750.x","volume":"82","author":"Daugbjerg","year":"1993","journal-title":"Acta Paediatr"},{"key":"R77-8-20090923","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1136\/thx.52.7.634","volume":"52","author":"van Woensel","year":"1997","journal-title":"Thorax"},{"key":"R78-8-20090923","doi-asserted-by":"crossref","first-page":"E44","DOI":"10.1542\/peds.105.4.e44","volume":"105","author":"Garrison","year":"2000","journal-title":"Pediatrics"},{"key":"R79-8-20090923","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1067\/mpd.2002.120271","volume":"140","author":"Schuh","year":"2002","journal-title":"J Pediatr"},{"key":"R80-8-20090923","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1016\/S0140-6736(03)14685-5","volume":"362","author":"Oommen","year":"2003","journal-title":"Lancet"},{"key":"R81-8-20090923","doi-asserted-by":"crossref","first-page":"E48","DOI":"10.1542\/peds.108.3.e48","volume":"108","author":"Knorr","year":"2001","journal-title":"Pediatrics"},{"key":"R82-8-20090923","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1164\/rccm.200207-747OC","volume":"167","author":"Bisgaard","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"R83-8-20090923","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1378\/chest.127.2.509","volume":"127","author":"Straub","year":"2005","journal-title":"Chest"}],"container-title":["Current Opinion in Pulmonary Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/01.mcp.0000199810.42011.8e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:07:04Z","timestamp":1785856024000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00063198-200601000-00008"}},"subtitle":[""],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":80,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1097\/01.mcp.0000199810.42011.8e","relation":{},"ISSN":["1070-5287"],"issn-type":[{"value":"1070-5287","type":"print"}],"subject":[],"published":{"date-parts":[[2006,1]]}}}