{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T23:33:24Z","timestamp":1792020804403,"version":"4.4.0"},"reference-count":19,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2009,1,3]],"date-time":"2009-01-03T00:00:00Z","timestamp":1230940800000},"content-version":"vor","delay-in-days":1251,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives\/Hypothesis:<\/jats:bold> Endolymphatic sac decompression is a surgical treatment option for patients with medically intractable Meniere's disease. However, effectiveness is debated because published data show great variability. Outcome\u2010based research studies are useful in incorporating the patient's perspective on the success of treatment. To further assess effectiveness of endolymphatic sac decompression, we performed a prospective study to examine both symptom\u2010specific and general health outcomes.<\/jats:p><jats:p><jats:bold>Study Design:<\/jats:bold> Prospective, observational outcome study.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Nineteen patients with endolymphatic sac decompression responded to symptom\u2010specific questionnaires and the Medical Outcomes Short\u2010Form 36 Health Survey (SF\u201036) before and after surgery. Follow\u2010up ranged from 6 to 58 months with a mean duration of 50 months.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Overall measures of physical health were significantly improved following endolymphatic sac decompression (<jats:italic>P<\/jats:italic> = .04), whereas overall measures of mental health were unchanged (<jats:italic>P<\/jats:italic> = .74). Role Physical and Social Functioning scores were significantly improved following endolymphatic sac decompression (<jats:italic>P<\/jats:italic> = .04 and <jats:italic>P<\/jats:italic> = .03, respectively). Study patients scored significantly lower (<jats:italic>P<\/jats:italic> &lt; .05) than SF\u201036 normative data in 6 of 10 categories before endolymphatic sac decompression but patient scores were not significantly different from normal scores in all but one category (General Health) following endolymphatic sac decompression. The mean number of vertigo episodes was significantly reduced from an average of 8.3 times per month to an average of 2.6 times per month following endolymphatic sac decompression (<jats:italic>P<\/jats:italic> = .006). Ninety\u2010five percent of patients (18 of 19 patients) reported improvement in symptoms (frequency, duration, or intensity) of vertigo and 37% (7 of 19 patients) reported complete resolution of vertigo.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Endolymphatic sac decompression significantly improved perception of physical health, as well as symptom\u2010specific outcomes, in patients with medically intractable Meniere's disease.<\/jats:p>","DOI":"10.1097\/01.mlg.0000171017.41592.d0","type":"journal-article","created":{"date-parts":[[2005,8,8]],"date-time":"2005-08-08T08:13:05Z","timestamp":1123488785000},"page":"1454-1457","source":"Crossref","is-referenced-by-count":46,"title":["Endolymphatic Sac Decompression as a Treatment for Meniere's Disease"],"prefix":"10.1002","volume":"115","author":[{"suffix":"Jr","given":"William F.","family":"Durland","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G Mark","family":"Pyle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine P.","family":"Connor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,3]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197905000-00010"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198311000-00009"},{"key":"e_1_2_5_4_2","first-page":"230","article-title":"What I think of sac surgery in 1989","volume":"10","author":"Glasscock ME","year":"1989","journal-title":"Am J Otol"},{"key":"e_1_2_5_5_2","first-page":"283","article-title":"Endolymphatic sac surgery for Meniere's disease: eighteen years' experience with the Kitahara sac operation","volume":"8","author":"Kitahara M","year":"1987","journal-title":"Am J 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