{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:06:25Z","timestamp":1792055185071,"version":"4.4.0"},"reference-count":17,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,1,2]],"date-time":"2009-01-02T00:00:00Z","timestamp":1230854400000},"content-version":"vor","delay-in-days":977,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["The Laryngoscope"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:<\/jats:bold> In this retrospective study, we tested the hypothesis that vestibular evoked myogenic potential (VEMP) thresholds are more often elevated or absent in patients with M\u00e9ni\u00e8re's disease experiencing Tumarkin drop attacks than in other patients with M\u00e9ni\u00e8re's disease.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Subjects included normal subjects (n = 14) and patients with unilateral M\u00e9ni\u00e8re's disease by AAO\u2010HNS (1995) diagnostic criteria with (n = 12) and without (n = 82) Tumarkin drop attacks at a large specialty hospital otology service. VEMP threshold testing was conducted using 250, 500, and 1,000 Hz tone burst stimuli.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> VEMP responses were present in at all frequencies in both ears of all normal subjects. In unaffected ears of patients with unilateral M\u00e9ni\u00e8re's disease, VEMPs were undetectable in 13% of measurements attempted. This number rose to 18% in affected ears of patients with unilateral M\u00e9ni\u00e8re's disease and to 41% in Meniere ears with Tumarkin drop attacks. Frequency tuning of the VEMP response in normal subjects showed lowest thresholds at 500 Hz. In Meniere ears, the tuning was altered such that the 500\u2010Hz thresholds were higher than the 1,000\u2010Hz thresholds. There was a gradient of threshold elevation and altered tuning that corresponded to the gradient of worsening disease.<\/jats:p><jats:p><jats:bold>Conclusion:<\/jats:bold> Our findings support the hypothesis that Tumarkin drop attacks arise from advanced disease involving the saccule and that VEMP may be a clinically valuable metric of disease severity or progression in patients with M\u00e9ni\u00e8re's disease.<\/jats:p>","DOI":"10.1097\/01.mlg.0000205129.78600.27","type":"journal-article","created":{"date-parts":[[2006,4,28]],"date-time":"2006-04-28T10:49:12Z","timestamp":1146221352000},"page":"776-779","source":"Crossref","is-referenced-by-count":75,"title":["Vestibular Evoked Myogenic Potential (VEMP) in Patients With M\u00e9ni\u00e8re's Disease With Drop Attacks"],"prefix":"10.1002","volume":"116","author":[{"given":"Ferdinand C. A.","family":"Timmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guangwei","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John J.","family":"Guinan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon G.","family":"Kujawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara S.","family":"Herrmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven D.","family":"Rauch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,1,2]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.57.2.190"},{"key":"e_1_2_6_3_2","doi-asserted-by":"crossref","first-page":"6058","DOI":"10.1523\/JNEUROSCI.14-10-06058.1994","article-title":"Acoustically responsive fibers in the vestibular nerve of the cat.","volume":"14","author":"McCue MP","year":"1994","journal-title":"J Neurosci"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200405000-00022"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.3942.175"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410280314"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200411000-00020"},{"key":"e_1_2_6_8_2","unstructured":"RauchSD TimmerFCA OrielBS et al.Vestibular evoked myogenic potential (VEMP) changes in unaffected ears of unilateral Meniere's disease. Association of Research in Otolaryngology (ARO) Mid\u2010Winter Meeting; New Orleans Louisiana; 2005."},{"key":"e_1_2_6_9_2","volume-title":"Statistical Methods","author":"Snedecor GW","year":"1967"},{"key":"e_1_2_6_10_2","first-page":"181","article-title":"American Academy of Otolaryngology\u2010Head Neck Foundation, Inc.","volume":"113","author":"Committee on Hearing and Equilibrium Guidelines for the Diagnosis and Evaluation of Therapy in Meniere's Disease","year":"1995","journal-title":"Otolaryngol Head Neck Surg."},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb02888.x"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s101620010053"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/00016480510033667"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.3109\/00016489609137880"},{"key":"e_1_2_6_15_2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3233\/VES-2001-11106","article-title":"Application of multivariate statistics to vestibular testing: discriminating between Meniere's disease and migraine associated dizziness.","volume":"11","author":"Dimitri PS","year":"2001","journal-title":"J Vestib Res"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"405","DOI":"10.3233\/VES-2002-11606","article-title":"Multivariate vestibular testing: laterality of unilateral Meniere's disease.","volume":"11","author":"Dimitri PS","year":"2001","journal-title":"J Vestib Res"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3233\/VES-2002-11605","article-title":"Multivariate vestibular testing: thresholds for bilateral Meniere's disease and aminoglycoside ototoxicity.","volume":"11","author":"Dimitri PS","year":"2001","journal-title":"J Vestib Res"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.129.8.815"}],"container-title":["The Laryngoscope"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1097%2F01.mlg.0000205129.78600.27","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1097\/01.mlg.0000205129.78600.27","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T01:58:24Z","timestamp":1696903104000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1097\/01.mlg.0000205129.78600.27"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":17,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1097\/01.mlg.0000205129.78600.27"],"URL":"https:\/\/doi.org\/10.1097\/01.mlg.0000205129.78600.27","archive":["Portico"],"relation":{},"ISSN":["0023-852X","1531-4995"],"issn-type":[{"value":"0023-852X","type":"print"},{"value":"1531-4995","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}