{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:49:49Z","timestamp":1785858589766,"version":"3.56.0"},"reference-count":57,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1097\/01.mnh.0000170751.56527.7e","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T06:29:14Z","timestamp":1122359354000},"page":"472-479","source":"Crossref","is-referenced-by-count":34,"title":["Integrated physiology of proximal tubular organic anion transport"],"prefix":"10.1097","volume":"14","author":[{"given":"Naohiko","family":"Anzai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Promsuk","family":"Jutabha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikatsu","family":"Kanai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hitoshi","family":"Endou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210205","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/j.tips.2004.10.006","article-title":"The multispecific organic anion transporter family: properties and pharmacological significance","volume":"25","author":"Miyazaki","year":"2004","journal-title":"Trends Pharmacol Sci"},{"key":"R2-10-20210205","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1152\/physrev.00040.2003","article-title":"Molecular and cellular physiology of renal organic cation and anion transport","volume":"84","author":"Wright","year":"2004","journal-title":"Physiol Rev"},{"key":"R3-10-20210205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.2174\/1389200043489207","article-title":"The role of organic ion transporters in drug disposition: an update","volume":"5","author":"You","year":"2004","journal-title":"Curr Drug Metab"},{"key":"R4-10-20210205","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1124\/mol.65.3.479","article-title":"The molecular pharmacology of organic anion transporters: from DNA to FDA?","volume":"65","author":"Eraly","year":"2004","journal-title":"Mol Pharmacol"},{"key":"R5-10-20210205","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1007\/s00424-003-1089-9","article-title":"The SLC22 drug transporter family","volume":"447","author":"Koepsell","year":"2004","journal-title":"Pfl\u00fcgers Arch"},{"key":"R6-10-20210205","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10254-002-0003-8","article-title":"Transport of organic anions across the basolateral membrane of proximal tubule cells","volume":"146","author":"Bruckhardt","year":"2003","journal-title":"Rev Physiol Biochem Pharmacol"},{"key":"R7-10-20210205","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1097\/00041552-200309000-00011","article-title":"Novel aspects of renal organic anion transporters","volume":"12","author":"Eraly","year":"2003","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R8-10-20210205","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.physiol.64.081501.155913","article-title":"Molecular aspects of renal anionic drug transport","volume":"64","author":"Russel","year":"2002","journal-title":"Annu Rev Physiol"},{"key":"R9-10-20210205","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1007\/s11926-996-0044-0","article-title":"Renal urate handling: clinical relevance of recent advances","volume":"7","author":"Anzai","year":"2005","journal-title":"Curr Rheumatol Rep"},{"key":"R10-10-20210205","first-page":"125","article-title":"Molecular physiology of urate transport","volume":"20","author":"Hediger","year":"2005","journal-title":"Physiology (Bethesda)"},{"key":"R11-10-20210205","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00041552-200309000-00005","article-title":"Uric acid transport","volume":"12","author":"Rafey","year":"2003","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R12-10-20210205","doi-asserted-by":"crossref","first-page":"4507","DOI":"10.1074\/jbc.275.6.4507","article-title":"Molecular cloning and characterization of multispecifc organic anion transporter 4 expressed in the placenta","volume":"275","author":"Cha","year":"2000","journal-title":"J Biol Chem"},{"key":"R13-10-20210205","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1254\/jphs.94.297","article-title":"Human organic anion transporter 4 is a renal apical organic anion\/dicarboxylate exchanger in the proximal tubules","volume":"94","author":"Ekaratanawong","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"R14-10-20210205","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1007\/BF00374407","article-title":"p-Aminohippurate\/2-oxoglutarate exchange in bovine renal brush-border and basolateral membrane vesicles","volume":"423","author":"Schmitt","year":"1993","journal-title":"Pfluegers Arch"},{"key":"R15-10-20210205","doi-asserted-by":"crossref","first-page":"F236","DOI":"10.1152\/ajprenal.00012.2004","article-title":"Identification and functional assessment of the novel murine organic anion transporter Oat5 (Slc22a19) expressed in kidney","volume":"287","author":"Youngblood","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"R16-10-20210205","first-page":"1250","article-title":"Characterization of a novel rat organic anion transporter OAT5 as an organic anion\/dicarboxylate exchanger at the apical membrane of renal proximal tubules [abstract]","volume":"18","author":"Hirata","year":"2004","journal-title":"FASEB J"},{"key":"R17-10-20210205","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/bbrc.2001.4774","article-title":"Isolation of a family of organic anion transporters from human liver and kidney","volume":"283","author":"Sun","year":"2001","journal-title":"Biochem Biophys Res Commun"},{"key":"R18-10-20210205","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/nature742","article-title":"Molecular identification of a renal urate anion exchanger that regulates blood urate levels","volume":"417","author":"Enomoto","year":"2002","journal-title":"Nature"},{"key":"R19-10-20210205","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00424-003-1168-y","article-title":"Organic anion transporting polypeptides of the OATP\/ SLC21 family: phylogenetic classification as OATP\/ SLCO superfamily, new nomenclature and molecular\/functional properties","volume":"447","author":"Hagenbuch","year":"2004","journal-title":"Pflugers Arch"},{"key":"R20-10-20210205","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2133\/dmpk.19.171","article-title":"The organic anion transporter (OATP) family","volume":"19","author":"Mikkaichi","year":"2004","journal-title":"Drug Metab Pharmacokinet"},{"key":"R21-10-20210205","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2174\/1389200033489460","article-title":"Drug uptake systems in liver and kidney","volume":"4","author":"van Montfoort","year":"2003","journal-title":"Curr Drug Metab"},{"key":"R22-10-20210205","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2133\/dmpk.18.91","article-title":"Functional characteristics and pharmacokinetic significance of kidney-specific organic anion transporters, OAT-K1 and OAT-K2, in the urinary excretion of anionic drugs","volume":"18","author":"Masuda","year":"2003","journal-title":"Drug Metab Pharmacokinet"},{"key":"R23-10-20210205","doi-asserted-by":"crossref","first-page":"3569","DOI":"10.1073\/pnas.0304987101","article-title":"Isolation and characterization of a digoxin transporter and its rat homologue expressed in the kidney","volume":"101","author":"Mikkaichi","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R24-10-20210205","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1007\/s00424-003-1087-y","article-title":"Organic anion transport is the primary function of the SLC17\/type I phosphate transporter family","volume":"447","author":"Reimer","year":"2004","journal-title":"Pflugers Arch"},{"key":"R25-10-20210205","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1006\/bbrc.2000.2407","article-title":"p-Aminohippuric acid transport at renal apical membrane mediated by human inorganic phosphate transporter NPT1","volume":"270","author":"Uchino","year":"2000","journal-title":"Biochem Biophys Res Commun"},{"key":"R26-10-20210205","doi-asserted-by":"crossref","first-page":"27930","DOI":"10.1074\/jbc.M303210200","article-title":"Identification of a novel voltage-driven organic anion transporter present at apical membrane of renal proximal tubule","volume":"278","author":"Jutabha","year":"2003","journal-title":"J Biol Chem"},{"key":"R27-10-20210205","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1038\/sj.onc.1206953","article-title":"The MRP family of drug efflux pumps","volume":"22","author":"Kruh","year":"2003","journal-title":"Oncogene"},{"key":"R28-10-20210205","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1681\/ASN.V133595","article-title":"The MRP4\/ABCC4 gene encodes a novel apical organic anion transporter in human kidney proximal tubules: putative efflux pump for urinary cAMP and cGMP","volume":"13","author":"van Aubel","year":"2002","journal-title":"J Am Soc Nephrol"},{"key":"R29-10-20210205","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1097\/01.ASN.0000143473.64430.AC","article-title":"Contribution of multidrug resistance protein 2 (MRP2\/ABCC2) to the renal excretion of p-aminohippurate (PAH) and identification of MRP4 (ABCC4) as a novel PAH transporter","volume":"15","author":"Smeets","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R30-10-20210205","doi-asserted-by":"crossref","first-page":"F327","DOI":"10.1152\/ajprenal.00133.2004","article-title":"Human organic anion transporter MRP4 (ABCC4) is an efflux pump for the purine end metabolite urate with multiple allosteric substrate binding sites","volume":"288","author":"van Aubel","year":"2005","journal-title":"Am J Physiol Renal Physiol"},{"key":"R31-10-20210205","doi-asserted-by":"crossref","first-page":"F797","DOI":"10.1152\/ajprenal.1994.266.5.F797","article-title":"Urate transport in brush-border membrane of human kidney","volume":"266","author":"Roch-Ramel","year":"1994","journal-title":"Am J Physiol Renal Physiol"},{"key":"R32-10-20210205","doi-asserted-by":"crossref","first-page":"13293","DOI":"10.1074\/jbc.C400059200","article-title":"Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids","volume":"279","author":"Miyauchi","year":"2004","journal-title":"J Biol Chem"},{"key":"R33-10-20210205","doi-asserted-by":"crossref","first-page":"44522","DOI":"10.1074\/jbc.M405365200","article-title":"Expression of slc5a8 in kidney and its role in Na(+)-coupled transport of lactate","volume":"279","author":"Gopal","year":"2004","journal-title":"J Biol Chem"},{"key":"R34-10-20210205","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1042\/BJ20041916","article-title":"Sodium-coupled and electrogenic transport of B-complex vitamin nicotinic acid by slc5a8, a member of the Na\/glucose co-transporter gene family","volume":"388","author":"Gopal","year":"2005","journal-title":"Biochem J"},{"key":"R35-10-20210205","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1042\/BST0330237","article-title":"Biological functions of SLC5A8, a candidate tumour suppressor","volume":"33","author":"Ganapathy","year":"2005","journal-title":"Biochem Soc Trans"},{"key":"R36-10-20210205","first-page":"89A","article-title":"Slc5a8 functions as a sodium-dependent pyrazionate and nicotinate cotransporter: implications for renal urate transport [abstract]","volume":"15","author":"Zandi-Nejad","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R37-10-20210205","doi-asserted-by":"crossref","first-page":"5699","DOI":"10.1074\/jbc.R100065200","article-title":"PDZ domains: structural modules for protein complex assembly","volume":"277","author":"Hung","year":"2002","journal-title":"J Biol Chem"},{"key":"R38-10-20210205","doi-asserted-by":"crossref","first-page":"C20","DOI":"10.1152\/ajpcell.00368.2004","article-title":"PDZ proteins retain and regulate membrane transporters in polarized epithelial cell membranes","volume":"288","author":"Brone","year":"2005","journal-title":"Am J Physiol Cell Physiol"},{"key":"R39-10-20210205","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/00041552-200409000-00014","article-title":"PDZ proteins and proximal ion transport","volume":"13","author":"Hernando","year":"2004","journal-title":"Curr Opin Nephrol Hypertens"},{"key":"R40-10-20210205","doi-asserted-by":"crossref","first-page":"F871","DOI":"10.1152\/ajprenal.00244.2004","article-title":"PDZ interactions and proximal tubular phosphate reabsorption","volume":"287","author":"Biber","year":"2004","journal-title":"Am J Physiol Renal Physiol"},{"key":"R41-10-20210205","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1097\/01.ASN.0000105320.04395.D0","article-title":"Clinical and molecular analysis of patients with renal hypouricemia in Japan: influence of URAT1 gene on urinary urate excretion","volume":"15","author":"Ichida","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R42-10-20210205","doi-asserted-by":"crossref","first-page":"45942","DOI":"10.1074\/jbc.M406724200","article-title":"The multivalent PDZ domain-containing protein PDZK1 regulates transport activity of renal urate\u2013anion exchanger URAT1 via its C-terminal","volume":"279","author":"Anzai","year":"2004","journal-title":"J Biol Chem"},{"key":"R43-10-20210205","first-page":"112","article-title":"Transport mechanisms of a renal apical drug transporter, organic anion transporter 4 [abstract]","volume":"94","author":"Miyazaki","year":"2004","journal-title":"J Pharmacol Sci"},{"key":"R44-10-20210205","first-page":"A695","article-title":"Identification of the intracellular binding protein with proton-coupled oligopeptide transporter PEPT2 using yeast two-hybrid assay [abstract]","volume":"18","author":"Anzai","year":"2004","journal-title":"FASEB J"},{"key":"R45-10-20210205","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/01.ASN.0000107560.80107.19","article-title":"Function and localization of urate transporter 1 in mouse kidney","volume":"15","author":"Hosoyamada","year":"2004","journal-title":"J Am Soc Nephrol"},{"key":"R46-10-20210205","doi-asserted-by":"crossref","first-page":"1733","DOI":"10.1046\/j.1523-1755.2003.00266.x","article-title":"PDZK1. I: A major scaffolder in brush borders of proximal tubular cells","volume":"64","author":"Gisler","year":"2003","journal-title":"Kidney Int"},{"key":"R47-10-20210205","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1046\/j.1523-1755.2003.00267.x","article-title":"PDZK1. II: An anchoring site for the PKA-binding protein D-AKAP2 in renal proximal tubular cells","volume":"64","author":"Gisler","year":"2003","journal-title":"Kidney Int"},{"key":"R48-10-20210205","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1023\/B:PHAM.0000045244.83999.43","article-title":"Screening of the interaction between xenobiotic transporters and PDZ proteins","volume":"21","author":"Kato","year":"2004","journal-title":"Pharm Res"},{"key":"R49-10-20210205","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1046\/j.1523-1755.2003.00346.x","article-title":"Scaffolds: orchestrating proteins to achieve concerted function","volume":"64","author":"Moe","year":"2003","journal-title":"Kidney Int"},{"key":"R50-10-20210205","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2003.12.011","article-title":"Stimulation of renal Na+-dicarboxylate cotransporter 1 by Na+\/H+ exchanger regulating factor 2, serum and glucocorticoid inducible kinase isoforms, and protein kinase B","volume":"313","author":"Boehmer","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R51-10-20210205","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1038\/nature02488","article-title":"Citric acid cycle intermediates as ligands for orphan G-protein-coupled receptors","volume":"429","author":"He","year":"2004","journal-title":"Nature"},{"key":"R52-10-20210205","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1517\/phgs.5.1.67.25683","article-title":"The genetic polymorphism of drug transporters: functional analysis approaches","volume":"5","author":"Ishikawa","year":"2004","journal-title":"Pharmacogenomics"},{"key":"R53-10-20210205","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1517\/phgs.5.3.273.29831","article-title":"Pharmacogenomics of the OATP and OAT families","volume":"5","author":"Marzolini","year":"2004","journal-title":"Pharmacogenomics"},{"key":"R54-10-20210205","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.bbrc.2004.02.063","article-title":"Genetic variant Arg57His in human H+\/peptide cotransporter 2 causes a complete loss of transport function","volume":"316","author":"Terada","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"R55-10-20210205","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1097\/01213011-200504000-00003","article-title":"Functional analysis of polymorphisms in the organic anion transporter, SLC22A6 (OAT1)","volume":"15","author":"Fujita","year":"2005","journal-title":"Pharmacogenet Genomics"},{"key":"R56-10-20210205","first-page":"120","article-title":"Regulation of renal urate transporter URAT1 transport function by PDZ domain protein PDZK1 [abstract]","volume":"97","author":"Anzai","year":"2005","journal-title":"J Pharmacol Sci"},{"key":"R57-10-20210205","first-page":"S8","article-title":"Identification of a novel organic anion transporter OAT8 from the rat kidney [abstract]","volume":"18","author":"Yokoyama","year":"2003","journal-title":"Nephrol Dial Transpl"}],"container-title":["Current Opinion in Nephrology & Hypertension"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/01.mnh.0000170751.56527.7e","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T14:55:57Z","timestamp":1785855357000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00041552-200509000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":57,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1097\/01.mnh.0000170751.56527.7e","relation":{},"ISSN":["1062-4821"],"issn-type":[{"value":"1062-4821","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}