{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T14:57:54Z","timestamp":1787756274807,"version":"build-2784847793"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":6981,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["mp.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Modern Pathology"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1097\/01.mp.0000097366.88165.08","type":"journal-article","created":{"date-parts":[[2003,12,17]],"date-time":"2003-12-17T21:23:05Z","timestamp":1071696185000},"page":"1265-1272","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":117,"title":["Dedifferentiated Adenoid Cystic Carcinoma: A Clinicopathologic Study of 6 Cases"],"prefix":"10.1016","volume":"16","author":[{"given":"Toshitaka","family":"Nagao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A","family":"Gaffey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiromi","family":"Serizawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isamu","family":"Sugano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuo","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuto","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoji","family":"Tokashiki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoyuki","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Minato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A","family":"Kay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean E","family":"Lewis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1097\/01.MP.0000097366.88165.08_bib1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1002\/1097-0142(197807)42:1<265::AID-CNCR2820420141>3.0.CO;2-Z","article-title":"Adenoid cystic carcinomas arising in salivary glands: a correlation of histologic features and clinical course","volume":"42","author":"Perzin","year":"1978","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib2","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1002\/1097-0142(19840915)54:6<1062::AID-CNCR2820540622>3.0.CO;2-E","article-title":"Histologic grading of adenoid cystic carcinoma of the salivary glands","volume":"54","author":"Szanto","year":"1984","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib3","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1002\/1097-0142(19860115)57:2<312::AID-CNCR2820570220>3.0.CO;2-A","article-title":"Adenoid cystic carcinoma of salivary glands: a study of 61 cases with clinicopathologic correlation","volume":"57","author":"Nascimento","year":"1986","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib4","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1177\/000348949009901215","article-title":"Histopathologic grading of salivary gland neoplasms: III. Adenoid cystic carcinomas","volume":"99","author":"Batsakis","year":"1990","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/1097-0142(197108)28:2<461::AID-CNCR2820280227>3.0.CO;2-U","article-title":"Dedifferentiation of low-grade chondrosarcomas","volume":"28","author":"Dahlin","year":"1971","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib6","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/019459988809800210","article-title":"Dedifferentiated acinic cell (acinous) carcinoma of the parotid gland","volume":"98","author":"Stanley","year":"1988","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib7","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1017\/S0022215100158578","article-title":"DNA flow cytometry of acinic cell carcinomas of major salivary glands","volume":"104","author":"el-Naggar","year":"1990","journal-title":"J Laryngol Otol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib8","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3109\/01913129609016347","article-title":"Helioid inclusions in dedifferentiated acinic cell carcinoma of the parotid gland","volume":"20","author":"Nunes","year":"1996","journal-title":"Ultrastruct Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib9","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1016\/S0046-8177(97)90164-7","article-title":"Dedifferentiated acinic cell carcinoma of the parotid gland: a distinct rarely described entity","volume":"28","author":"Henley","year":"1997","journal-title":"Hum Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib10","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s004280050353","article-title":"Unilateral aneuploid dedifferentiated acinic cell carcinoma associated with bilateral-low grade diploid acinic cell carcinoma of the parotid gland","volume":"434","author":"Di Palma","year":"1999","journal-title":"Virchows Arch"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib11","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.5858\/2002-126-1104-DACCOT","article-title":"Dedifferentiated acinic cell carcinoma of the parotid gland with myoepithelial features","volume":"126","author":"Piana","year":"2002","journal-title":"Arch Pathol Lab Med"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib12","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1097\/00000478-199904000-00012","article-title":"Dedifferentiation in adenoid cystic carcinoma of salivary gland: an uncommon complication associated with an accelerated clinical course","volume":"23","author":"Cheuk","year":"1999","journal-title":"Am J Surg Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S1079-2104(99)70114-9","article-title":"Dedifferentiation occurring in adenoid cystic carcinoma of the tongue","volume":"88","author":"Moles","year":"1999","journal-title":"Oral Surg Oral Med Oral Pathol Oral Radiol Endod"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib14","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1053\/hupa.2001.28966","article-title":"Dedifferentiation of adenoid cystic carcinoma: report of a case implicating p53 gene mutation","volume":"32","author":"Chau","year":"2001","journal-title":"Hum Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib15","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s004280050344","article-title":"High-grade carcinoma component in epithelial-myoepithelial carcinoma of salivary glands: clinicopathological, immunohistochemical and flow-cytometric study of three cases","volume":"434","author":"Alos","year":"1999","journal-title":"Virchows Arch"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib16","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1097\/00000478-200003000-00018","article-title":"Dedifferentiation in salivary gland carcinomas","volume":"24","author":"Fonseca","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib17","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1093\/ajcp\/111.6.785","article-title":"Histologic transformation of polymorphous low-grade adenocarcinoma of salivary gland","volume":"111","author":"Pelkey","year":"1999","journal-title":"Am J Clin Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib18","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1046\/j.1365-2559.2002.01439.x","article-title":"Polymorphous low-grade adenocarcinoma of the salivary glands with transformation to high-grade carcinoma","volume":"41","author":"Simpson","year":"2002","journal-title":"Histopathology"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib19","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/modpathol.3880096","article-title":"Primary large-cell neuroendocrine carcinoma of the parotid gland: immunohistochemical and molecular analysis of two cases","volume":"13","author":"Nagao","year":"2000","journal-title":"Mod Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib20","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/bjc.1993.236","article-title":"Rapid detection of allele loss in colorectal tumours using microsatellites and fluorescent DNA technology","volume":"67","author":"Cawkwell","year":"1993","journal-title":"Br J Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib21","first-page":"37","article-title":"\u201cDedifferentiation\u201d in bone and soft-tissue tumors: a histological indicator of tumor progression","volume":"26","author":"Meis","year":"1991","journal-title":"Pathol Annu"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib22","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/modpathol.3880525","article-title":"Salivary gland neoplasia: a review for the practicing pathologist","volume":"15","author":"Zarbo","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib23","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/0030-4220(90)90381-2","article-title":"Solid adenoid cystic carcinoma of the maxilla","volume":"69","author":"Cleveland","year":"1990","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib24","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1097\/00005537-199704000-00019","article-title":"Ki-67 as a prognostic marker in adenoid cystic carcinoma assessed with the monoclonal antibody MIB1 in paraffin sections","volume":"107","author":"Nordgard","year":"1997","journal-title":"Laryngoscope"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib25","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/0964-1955(95)00059-3","article-title":"Hybrid tumours of salivary glands: definition and classification of five rare cases","volume":"32B","author":"Seifert","year":"1996","journal-title":"Eur J Cancer B Oral Oncol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib26","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1097\/01.MP.0000018977.18942.FD","article-title":"Hybrid carcinomas of the salivary glands: report of nine cases with a clinicopathologic, immunohistochemical, and p53 gene alteration analysis","volume":"15","author":"Nagao","year":"2002","journal-title":"Mod Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/(SICI)1097-0142(19960115)77:2<223::AID-CNCR1>3.0.CO;2-N","article-title":"Salivary duct carcinoma: clinicopathologic and immunohistochemical review of 26 cases","volume":"77","author":"Lewis","year":"1996","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib28","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s004280050060","article-title":"A hybrid carcinoma: adenoid cystic carcinoma and salivary duct carcinoma of the salivary gland: an immunohistochemical study","volume":"430","author":"Kamio","year":"1997","journal-title":"Virchows Arch"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib29","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1046\/j.1365-2559.1999.00761.x","article-title":"Hybrid carcinoma of the salivary gland: salivary duct adenocarcinoma adenoid cystic carcinoma","volume":"35","author":"Snyder","year":"1999","journal-title":"Histopathology"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib30","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1002\/1097-0142(19950415)75:8<2037::AID-CNCR2820750802>3.0.CO;2-V","article-title":"p53 oncoprotein expression in parotid gland carcinoma is associated with clinical outcome","volume":"75","author":"Gallo","year":"1995","journal-title":"Cancer"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/BF00193934","article-title":"Coexpression of p53 and c-erbB-2 proteins is associated with histological type, tumour stage, and cell proliferation in malignant salivary gland tumours","volume":"428","author":"Kamio","year":"1996","journal-title":"Virchows Arch"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib32","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/S0046-8177(96)90316-0","article-title":"Loss of heterozygosity and microsatellite alterations in p53 and RB genes in adenoid cystic carcinoma of the salivary glands","volume":"27","author":"Yamamoto","year":"1996","journal-title":"Hum Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib33","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1136\/jcp.50.8.661","article-title":"Immunoexpression of c-erbB-2 and p53 in benign and malignant salivary neoplasms with myoepithelial differentiation","volume":"50","author":"Rosa","year":"1997","journal-title":"J Clin Pathol"},{"key":"10.1097\/01.MP.0000097366.88165.08_bib34","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1007\/s004280050478","article-title":"Mutation of p53 with loss of heterozygosity in the osteosarcomatous component of a dedifferentiated chondrosarcoma","volume":"436","author":"Grote","year":"2000","journal-title":"Virchows Arch"}],"container-title":["Modern Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522204683X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S089339522204683X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,2,13]],"date-time":"2023-02-13T04:27:20Z","timestamp":1676262440000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S089339522204683X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S089339522204683X"],"URL":"https:\/\/doi.org\/10.1097\/01.mp.0000097366.88165.08","relation":{},"ISSN":["0893-3952"],"issn-type":[{"value":"0893-3952","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dedifferentiated Adenoid Cystic Carcinoma: A Clinicopathologic Study of 6 Cases","name":"articletitle","label":"Article Title"},{"value":"Modern Pathology","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1097\/01.MP.0000097366.88165.08","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2003 United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}]}}