{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T22:34:35Z","timestamp":1762900475688},"reference-count":12,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":["lww.com","ovid.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract:<\/jats:title>\n          <jats:p>In the last several decades, postexposure prophylaxis (PEP) with antiretroviral therapy (ART) has become an effective tool for the prevention of HIV transmission. The continuous evolution of antiretrovirals and the associated update of clinical practice guidelines create a challenge for NPs caring for patients exposed to HIV. Understanding the life cycle of HIV is of paramount importance in streamlining treatment regimens in exposed individuals. ART is a complex combination of drugs targeting different stages of the virus's life cycle within the host. NPs play an essential role in managing treatment for people exposed to HIV and following up on these patients' response and adherence to the treatment protocol. This article provides a comprehensive overview of HIV and step-by-step guidance for NPs treating patients who have been exposed.<\/jats:p>","DOI":"10.1097\/01.npr.0000000000000041","type":"journal-article","created":{"date-parts":[[2023,4,25]],"date-time":"2023-04-25T14:01:25Z","timestamp":1682431285000},"page":"39-47","update-policy":"http:\/\/dx.doi.org\/10.1097\/lww.0000000000001000","source":"Crossref","is-referenced-by-count":1,"title":["Postexposure prophylaxis (PEP) of HIV among adults"],"prefix":"10.1097","volume":"48","author":[{"given":"Mohamed Toufic","family":"El Hussein","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivan","family":"Malyshev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R4-20240814","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.ajem.2020.10.004","article-title":"HIV post-exposure prophylaxis in the emergency department: an updated assessment and opportunities for HIV prevention identified","volume":"46","author":"O'Connell","year":"2021","journal-title":"Am J Emerg Med"},{"key":"R5-20240814","article-title":"Post-exposure prophylaxis (PEP)","author":"Arkell","year":"2021","journal-title":"CATIE"},{"journal-title":"PEP to Prevent HIV Infection","year":"2022","author":"DeHaan","key":"R6-20240814"},{"issue":"3","key":"R10-20240814","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1007\/s12035-012-8320-7","article-title":"Infectious agents and neurodegeneration","volume":"46","author":"De Chiara","year":"2012","journal-title":"Mol Neurobiol"},{"issue":"47","key":"R11-20240814","doi-asserted-by":"crossref","first-page":"E1448","DOI":"10.1503\/cmaj.170494","article-title":"Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis","volume":"189","author":"Tan","year":"2017","journal-title":"CMAJ"},{"issue":"10","key":"R12-20240814","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1097\/QAD.0000000000000298","article-title":"Estimating per-act HIV transmission risk: a systematic review","volume":"28","author":"Patel","year":"2014","journal-title":"AIDS (London, England)"},{"author":"Dominguez","key":"R13-20240814","article-title":"Updated guidelines for antiretroviral postexposure prophylaxis after sexual, injection drug use, or other nonoccupational exposure to HIV\u2014United States, 2016"},{"issue":"5","key":"R15-20240814","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1001\/jama.2018.21167","article-title":"HIV viral load and transmissibility of HIV infection: undetectable equals untransmittable","volume":"321","author":"Eisinger","year":"2019","journal-title":"JAMA"},{"issue":"suppl 3","key":"R16-20240814","doi-asserted-by":"crossref","first-page":"S161","DOI":"10.1093\/cid\/civ068","article-title":"World Health Organization guidelines on postexposure prophylaxis for HIV: recommendations for a public health approach","volume":"60","author":"Ford","year":"2015","journal-title":"Clin Infect Dis"},{"issue":"6","key":"R17-20240814","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1089\/apc.2016.0274","article-title":"Sexual assault and HIV postexposure prophylaxis at an urban African hospital","volume":"31","author":"Muriuki","year":"2017","journal-title":"AIDS Patient Care STDS"},{"key":"R18-20240814","first-page":"8","article-title":"\u201cReclaiming control\u201d patient acceptance and adherence to HIV post-exposure prophylaxis following sexual assault","author":"Draughon Moret","year":"2021","journal-title":"Glob Qual Nurs Res"},{"issue":"11","key":"R23-20240814","doi-asserted-by":"crossref","first-page":"e0142534","DOI":"10.1371\/journal.pone.0142534","article-title":"Adherence to post-exposure prophylaxis (PEP) and incidence of HIV seroconversion in a major North American cohort","volume":"10","author":"Thomas","year":"2015","journal-title":"PLoS One"}],"container-title":["The Nurse Practitioner"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/01.NPR.0000000000000041","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,15]],"date-time":"2024-08-15T00:27:47Z","timestamp":1723681667000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/10.1097\/01.NPR.0000000000000041"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":12,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023]]}},"URL":"https:\/\/doi.org\/10.1097\/01.npr.0000000000000041","relation":{},"ISSN":["0361-1817"],"issn-type":[{"type":"print","value":"0361-1817"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}