{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T11:12:59Z","timestamp":1785928379370,"version":"3.56.0"},"reference-count":26,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,8]]},"DOI":"10.1097\/01.pas.0000128671.92609.af","type":"journal-article","created":{"date-parts":[[2004,7,13]],"date-time":"2004-07-13T04:02:51Z","timestamp":1089691371000},"page":"1051-1056","source":"Crossref","is-referenced-by-count":44,"title":["Aberrant Bcl6 Protein Expression in Mantle Cell Lymphoma"],"prefix":"10.1097","volume":"28","author":[{"given":"Francisca I","family":"Camacho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan F","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan C","family":"Cigudosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuela","family":"Mollejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrocinio","family":"Algara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ru\u00edz-Ballesteros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Gonzalvo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paloma","family":"Mart\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"P\u00e9rez-Seoane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joaqu\u00edn","family":"S\u00e1nchez-Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A","family":"Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-10-20210130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V99.4.1299","article-title":"Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course.","volume":"99","author":"Algara","year":"2002","journal-title":"Blood"},{"key":"R2-10-20210130","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1016\/S0002-9440(10)62564-3","article-title":"A short mutational hot spot in the first intron of BCL-6 is associated with increased BCL-6 expression and with longer overall survival in large B-cell lymphomas.","volume":"160","author":"Artiga","year":"2002","journal-title":"Am J Pathol"},{"key":"R3-10-20210130","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1182\/blood.V83.9.2423.2423","article-title":"LAZ3 rearrangements in non-Hodgkins lymphoma: correlation with histology, immunophenotype, karyotype, and clinical outcome in 217 patients.","volume":"83","author":"Bastard","year":"1994","journal-title":"Blood"},{"key":"R4-10-20210130","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1182\/blood-2002-11-3456","article-title":"Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations.","volume":"101","author":"Camacho","year":"2003","journal-title":"Blood"},{"key":"R5-10-20210130","first-page":"651","article-title":"Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasia.","volume":"95","author":"Capello","year":"2000","journal-title":"Blood"},{"key":"R6-10-20210130","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1182\/blood.V91.2.603","article-title":"Heterologous promoters fused to BCL6 by chromosomal translocations affecting band 3q27 cause its deregulated expression during B-cell differentiation.","volume":"91","author":"Chen","year":"1998","journal-title":"Blood"},{"key":"R7-10-20210130","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1309\/U98ADVKUC26R2RJA","article-title":"B-cell lymphomas with coexpression of CD5 and CD10.","volume":"119","author":"Dong","year":"2003","journal-title":"Am J Clin Pathol"},{"key":"R8-10-20210130","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1097\/00019606-200112000-00002","article-title":"Use of novel t(11;14) and t(14;18) dual-fusion fluorescence in situ hybridization probes in the differential diagnosis of lymphomas of small lymphocytes.","volume":"10","author":"Frater","year":"2001","journal-title":"Diagn Mol Pathol"},{"key":"R9-10-20210130","first-page":"3755","article-title":"Frequent mutation of the 5 noncoding region of the BCL-6 gene in acquired immunodeficiency syndrome-related non-Hodgkins lymphomas.","volume":"89","author":"Gaidano","year":"1997","journal-title":"Blood"},{"key":"R11-10-20210130","doi-asserted-by":"crossref","first-page":"4955","DOI":"10.1002\/j.1460-2075.1993.tb06189.x","article-title":"Tracing B cell development in human germinal centres by molecular analysis of single cells picked from histological sections.","volume":"12","author":"Kuppers","year":"1993","journal-title":"EMBO J"},{"key":"R12-10-20210130","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1309\/TE56-A43X-29TT-5H8G","article-title":"CD5- mantle cell lymphoma.","volume":"118","author":"Liu","year":"2002","journal-title":"Am J Clin Pathol"},{"key":"R13-10-20210130","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.1182\/blood.V83.7.1757.1757","article-title":"Rearrangements of the BCL6 gene in diffuse large cell non-Hodgkins lymphoma.","volume":"83","author":"Lo Coco","year":"1994","journal-title":"Blood"},{"key":"R14-10-20210130","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1182\/blood.V95.4.1400.004k43_1400_1405","article-title":"Mutation analysis of the 5 noncoding regulatory region of the BCL-6 gene in non-Hodgkin lymphoma: evidence for recurrent mutations and intraclonal heterogeneity.","volume":"95","author":"Lossos","year":"2000","journal-title":"Blood"},{"key":"R15-10-20210130","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/sj.leu.2402073","article-title":"Molecular heterogeneity of splenic marginal zone lymphomas: analysis of mutations in the 5 non-coding region of the bcl-6 gene.","volume":"15","author":"Mateo","year":"2001","journal-title":"Leukemia"},{"key":"R16-10-20210130","doi-asserted-by":"crossref","first-page":"12520","DOI":"10.1073\/pnas.92.26.12520","article-title":"Frequent somatic hypermutation of the 5 noncoding region of the BCL6 gene in B-cell lymphoma.","volume":"92","author":"Migliazza","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"R17-10-20210130","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1007\/s002770050293","article-title":"BCL6 rearrangement in a patient with mantle cell lymphoma.","volume":"74","author":"Miura","year":"1997","journal-title":"Ann Hematol"},{"key":"R18-10-20210130","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1182\/blood.V85.10.2877.bloodjournal85102877","article-title":"Analysis of LAZ3 (BCL-6) status in B-cell non-Hodgkins lymphomas: results of rearrangement and gene expression studies and a mutational analysis of coding region sequences.","volume":"85","author":"Otsuki","year":"1995","journal-title":"Blood"},{"key":"R19-10-20210130","doi-asserted-by":"crossref","first-page":"11816","DOI":"10.1073\/pnas.95.20.11816","article-title":"BCL-6 mutations in normal germinal center B cells: evidence of somatic hypermutation acting outside Ig loci.","volume":"95","author":"Pasqualucci","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"R20-10-20210130","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.1182\/blood.V93.7.2167","article-title":"Nonimmunoglobulin gene hypermutation in germinal center B cells.","volume":"93","author":"Peng","year":"1999","journal-title":"Blood"},{"key":"R21-10-20210130","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1111\/j.1365-2141.1990.tb07836.x","article-title":"The 14;18 translocation in European cases of follicular lymphoma: comparison of Southern blotting and the polymerase chain reaction.","volume":"76","author":"Pezzella","year":"1990","journal-title":"Br J Haematol"},{"key":"R22-10-20210130","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0002-9440(10)65558-7","article-title":"Mantle cell lymphomas lack expression of p27Kip1, a cyclin-dependent kinase inhibitor.","volume":"153","author":"Quintanilla-Martinez","year":"1998","journal-title":"Am J Pathol"},{"key":"R23-10-20210130","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1034\/j.1600-0609.2002.01677.x","article-title":"Ki-67 expression level, histological subtype, and the International Prognostic Index as outcome predictors in mantle cell lymphoma.","volume":"69","author":"Raty","year":"2002","journal-title":"Eur J Haematol"},{"key":"R24-10-20210130","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1182\/blood-2002-07-2009","article-title":"Cell cycle deregulation in B-cell lymphomas.","volume":"101","author":"Sanchez-Beato","year":"2003","journal-title":"Blood"},{"key":"R25-10-20210130","doi-asserted-by":"crossref","first-page":"1750","DOI":"10.1126\/science.280.5370.1750","article-title":"Mutation of BCL-6 gene in normal B cells by the process of somatic hypermutation of Ig genes.","volume":"280","author":"Shen","year":"1998","journal-title":"Science"},{"key":"R26-10-20210130","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1034\/j.1600-0609.2002.01662.x","article-title":"Somatic hypermutation and V(H) gene usage in mantle cell lymphoma.","volume":"68","author":"Thorselius","year":"2002","journal-title":"Eur J Haematol"},{"key":"R27-10-20210130","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1002\/j.1460-2075.1995.tb00311.x","article-title":"Chromosomal translocations cause deregulated BCL6 expression by promoter substitution in B cell lymphoma.","volume":"14","author":"Ye","year":"1995","journal-title":"EMBO J"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-200408000-00010","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:17:55Z","timestamp":1785784675000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-200408000-00010"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,8]]},"references-count":26,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1097\/01.pas.0000128671.92609.af","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2004,8]]}}}