{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,12]],"date-time":"2026-11-12T05:36:23Z","timestamp":1794461783138,"version":"4.9.1"},"reference-count":35,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1097\/01.pas.0000194044.01104.25","type":"journal-article","created":{"date-parts":[[2006,5,12]],"date-time":"2006-05-12T07:56:02Z","timestamp":1147420562000},"page":"560-574","source":"Crossref","is-referenced-by-count":205,"title":["Microadenomatosis of the Endocrine Pancreas in Patients With and Without the Multiple Endocrine Neoplasia Type 1 Syndrome"],"prefix":"10.1097","volume":"30","author":[{"given":"Martin","family":"Anlauf","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina","family":"Schlenger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurel","family":"Perren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliane","family":"Bauersfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian A.","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henning","family":"Dralle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Raffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfram T.","family":"Knoefel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eberhard","family":"Weihe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Ruszniewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Couvelard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Komminoth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philipp U.","family":"Heitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00fcnter","family":"Kl\u00f6ppel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-2-20210130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1196\/annals.1294.020","article-title":"Molecular pathology of the MEN1 gene","volume":"1014","author":"Agarwal","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"R2-2-20210130","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1093\/ajcp\/91.3.336","article-title":"Nesidioblastosis of the pancreas in an adult with persistent hyperinsulinemic hypoglycemia","volume":"91","author":"Albers","year":"1989","journal-title":"Am J Clin Pathol"},{"key":"R3-2-20210130","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1053\/j.gastro.2005.01.058","article-title":"Precursor lesions in patients with multiple endocrine neoplasia type 1-associated duodenal gastrinomas","volume":"128","author":"Anlauf","year":"2005","journal-title":"Gastroenterology"},{"key":"R4-2-20210130","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1177\/002215540004801205","article-title":"Localization of xenin-immunoreactive cells in the duodenal mucosa of humans and various mammals","volume":"48","author":"Anlauf","year":"2000","journal-title":"J Histochem Cytochem"},{"key":"R5-2-20210130","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1210\/jc.2004-0218","article-title":"Cutaneous tumors in patients with multiple endocrine neoplasm type 1 (MEN1) and gastrinomas: prospective study of frequency and development of criteria with high sensitivity and specificity for MEN1","volume":"89","author":"Asgharian","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R6-2-20210130","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1210\/me.2003-0154","article-title":"Heterozygous Men1 mutant mice develop a range of endocrine tumors mimicking multiple endocrine neoplasia type 1","volume":"17","author":"Bertolino","year":"2003","journal-title":"Mol Endocrinol"},{"key":"R7-2-20210130","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1128\/MCB.24.8.3125-3131.2004","article-title":"Conditional inactivation of the MEN1 gene leads to pancreatic and pituitary tumorigenesis but does not affect normal development of these tissues","volume":"24","author":"Biondi","year":"2004","journal-title":"Mol Cell Biol"},{"key":"R8-2-20210130","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1093\/ajcp\/88.2.153","article-title":"Multiple islet cell tumors with predominance of glucagon-producing cells and ulcer disease","volume":"88","author":"Bordi","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"R9-2-20210130","doi-asserted-by":"crossref","first-page":"5658","DOI":"10.1210\/jcem.86.12.8070","article-title":"Guidelines for diagnosis and therapy of MEN type 1 and type 2","volume":"86","author":"Brandi","year":"2001","journal-title":"J Clin Endocrinol Metab"},{"key":"R10-2-20210130","doi-asserted-by":"crossref","first-page":"1968","DOI":"10.1073\/pnas.87.5.1968","article-title":"Localization of the MEN1 gene to a small region within chromosome 11q13 by deletion mapping in tumors","volume":"87","author":"Bystrom","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"R12-2-20210130","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1126\/science.276.5311.404","article-title":"Positional cloning of the gene for multiple endocrine neoplasia- type 1","volume":"276","author":"Chandrasekharappa","year":"1997","journal-title":"Science"},{"key":"R13-2-20210130","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1073\/pnas.98.3.1118","article-title":"A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors","volume":"98","author":"Crabtree","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"R14-2-20210130","doi-asserted-by":"crossref","first-page":"6075","DOI":"10.1128\/MCB.23.17.6075-6085.2003","article-title":"Of mice and MEN1: insulinomas in a conditional mouse knockout","volume":"23","author":"Crabtree","year":"2003","journal-title":"Mol Cell Biol"},{"key":"R15-2-20210130","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1210\/jc.2004-1155","article-title":"Thymic neuroendocrine carcinoma (carcinoid) in multiple endocrine neoplasia type 1 syndrome: the Italian series","volume":"90","author":"Ferolla","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"R16-2-20210130","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1053\/gast.2002.36590","article-title":"Xenin-immunoreactive cells and extractable xenin in neuroendocrine tumors of duodenal origin","volume":"123","author":"Feurle","year":"2002","journal-title":"Gastroenterology"},{"key":"R17-2-20210130","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1056\/NEJM198907273210402","article-title":"Clonality of parathyroid tumors in familial multiple endocrine neoplasia type 1","volume":"321","author":"Friedman","year":"1989","journal-title":"N Engl J Med"},{"key":"R18-2-20210130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1086\/301953","article-title":"Germ-line mutation analysis in patients with multiple endocrine neoplasia type 1 and related disorders","volume":"63","author":"Giraud","year":"1998","journal-title":"Am J Hum Genet"},{"key":"R19-2-20210130","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1210\/mend.15.10.0717","article-title":"Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia type-1","volume":"15","author":"Guo","year":"2001","journal-title":"Mol Endocrinol"},{"key":"R21-2-20210130","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1002\/1097-0142(19860501)57:9<1824::AID-CNCR2820570920>3.0.CO;2-Q","article-title":"Pancreatic lesions and hormonal profile of pancreatic tumors in multiple endocrine neoplasia type I: an immunocytochemical study of nine patients","volume":"57","author":"Kl\u00f6ppel","year":"1986","journal-title":"Cancer"},{"key":"R22-2-20210130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1046\/j.1365-2796.1998.00274.x","article-title":"Pathology of MEN-1: morphology, clinicopathologic correlations and tumour development","volume":"243","author":"Komminoth","year":"1998","journal-title":"J Intern Med"},{"key":"R23-2-20210130","first-page":"922","article-title":"Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing","volume":"145","author":"Komminoth","year":"1994","journal-title":"Am J Pathol"},{"key":"R24-2-20210130","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1002\/1097-0142(19950801)76:3<479::AID-CNCR2820760319>3.0.CO;2-M","article-title":"Analysis of RET protooncogene point mutations distinguishes heritable from nonheritable medullary thyroid carcinomas","volume":"76","author":"Komminoth","year":"1995","journal-title":"Cancer"},{"key":"R25-2-20210130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/332085a0","article-title":"Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma","volume":"332","author":"Larsson","year":"1988","journal-title":"Nature"},{"key":"R26-2-20210130","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1097\/00000478-199611000-00009","article-title":"Immunohistochemical study of 100 pancreatic tumors in 28 patients with multiple endocrine neoplasia, type I","volume":"20","author":"Le Bodic","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R27-2-20210130","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1093\/hmg\/6.7.1177","article-title":"Identification of the multiple endocrine neoplasia type 1 (MEN1) gene: the European Consortium on MEN1","volume":"6","author":"Lemmens","year":"1997","journal-title":"Hum Mol Genet"},{"key":"R28-2-20210130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0002-9440(10)65563-0","article-title":"Multiple neuroendocrine tumors of the pancreas in von Hippel-Lindau disease patients: histopathological and molecular genetic analysis","volume":"153","author":"Lubensky","year":"1998","journal-title":"Am J Pathol"},{"key":"R29-2-20210130","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1056\/NEJM199908263410902","article-title":"Surgery to cure the Zollinger-Ellison syndrome","volume":"341","author":"Norton","year":"1999","journal-title":"N Engl J Med"},{"key":"R30-2-20210130","doi-asserted-by":"crossref","first-page":"7605","DOI":"10.1038\/sj.onc.1205812","article-title":"Absence of somatic SDHD mutations in sporadic neuroendocrine tumors and detection of two germline variants in paraganglioma patients","volume":"21","author":"Perren","year":"2002","journal-title":"Oncogene"},{"key":"R31-2-20210130","doi-asserted-by":"crossref","first-page":"1815","DOI":"10.1002\/1097-0142(19880501)61:9<1815::AID-CNCR2820610916>3.0.CO;2-L","article-title":"Nonrandom expression of polypeptide hormones in pancreatic endocrine tumors: an immunohistochemical study in a case of multiple islet cell neoplasia","volume":"61","author":"Pilato","year":"1988","journal-title":"Cancer"},{"key":"R32-2-20210130","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1056\/NEJM199003153221103","article-title":"Gastrinomas in the duodenums of patients with multiple endocrine neoplasia type 1 and the Zollinger-Ellison syndrome","volume":"322","author":"Pipeleers-Marichal","year":"1990","journal-title":"N Engl J Med"},{"key":"R33-2-20210130","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1007\/s00428-003-0784-4","article-title":"A comprehensive characterization of pancreatic ductal carcinoma cell lines: towards the establishment of an in vitro research platform","volume":"442","author":"Sipos","year":"2003","journal-title":"Virchows Arch"},{"key":"R34-2-20210130","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/BF01654938","article-title":"MEN 1 pancreas: a histological and immunohistochemical study","volume":"8","author":"Thompson","year":"1984","journal-title":"World J Surg"},{"key":"R35-2-20210130","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1210\/jc.2003-031575","article-title":"Non-islet origin of pancreatic islet cell tumors","volume":"89","author":"Vortmeyer","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"key":"R36-2-20210130","first-page":"919","article-title":"Multiple endocrine neoplasia type 1: atypical presentation, clinical course, and genetic analysis of multiple tumors","volume":"12","author":"Vortmeyer","year":"1999","journal-title":"Mod Pathol"},{"key":"R37-2-20210130","first-page":"5446","article-title":"Mutations of the MEN1 tumor suppressor gene in pituitary tumors","volume":"57","author":"Zhuang","year":"1997","journal-title":"Cancer Res"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00042192-200613050-00006","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T15:25:32Z","timestamp":1785857132000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-200605000-00002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006]]}},"URL":"https:\/\/doi.org\/10.1097\/01.pas.0000194044.01104.25","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}