{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T12:31:13Z","timestamp":1791117073512,"version":"4.1.0"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,3]]},"DOI":"10.1097\/01.pas.0000213419.08009.b0","type":"journal-article","created":{"date-parts":[[2007,2,21]],"date-time":"2007-02-21T03:55:48Z","timestamp":1172030148000},"page":"438-446","source":"Crossref","is-referenced-by-count":46,"title":["Splenic Marginal-zone Lymphoma: One or More Entities? A Histologic, Immunohistochemical, and Molecular Study of 42 Cases"],"prefix":"10.1097","volume":"31","author":[{"given":"Theodora","family":"Papadaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kostas","family":"Stamatopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chrysoula","family":"Belessi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evi","family":"Pouliou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aikaterini","family":"Parasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassiliki","family":"Douka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolaos","family":"Laoutaris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Athanasios","family":"Fassas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achilles","family":"Anagnostopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dimitra","family":"Anagnostou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-13-20210130","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1159\/000204496","article-title":"A CD5+ leukemic lymphoma with monocytoid features: an unusual B-cell lymphoma mimicking hairy-cell leukemia","volume":"89","author":"Adami","year":"1993","journal-title":"Acta Haematol"},{"key":"R2-13-20210130","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V99.4.1299","article-title":"Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and diverse clinical course","volume":"99","author":"Algara","year":"2002","journal-title":"Blood"},{"key":"R3-13-20210130","first-page":"80","article-title":"Marginal zone-related neoplasms of splenic and nodal origin","volume":"88","author":"Arcaini","year":"2003","journal-title":"Haematologica"},{"key":"R4-13-20210130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9440(10)64159-4","article-title":"Splenic marginal zone lymphomas appear to originate from different B cell types","volume":"161","author":"Bahler","year":"2002","journal-title":"Am J Pathol"},{"key":"R5-13-20210130","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/S1074-7613(01)00135-2","article-title":"The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21","volume":"14","author":"Cariappa","year":"2001","journal-title":"Immunity"},{"key":"R6-13-20210130","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0740-2570(03)00012-1","article-title":"Splenic marginal zone lymphoma","volume":"20","author":"Dogan","year":"2003","journal-title":"Semin Diagn Pathol"},{"key":"R7-13-20210130","first-page":"173","article-title":"Immunoglobulin gene mutation patterns and heterogeneity of marginal zone lymphoma","volume":"115","author":"Dono","year":"2005","journal-title":"Methods Mol Med"},{"key":"R8-13-20210130","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.4049\/jimmunol.164.11.5596","article-title":"Heterogeneity of tonsillar subepithelial B lymphocytes, the splenic marginal zone equivalents","volume":"164","author":"Dono","year":"2000","journal-title":"J Immunol"},{"key":"R9-13-20210130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1749-6632.2003.tb06039.x","article-title":"The human marginal zone B cell","volume":"987","author":"Dono","year":"2003","journal-title":"Ann N Y Acad Sci"},{"key":"R10-13-20210130","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1084\/jem.182.2.559","article-title":"Analysis of mutations in immunoglobulin heavy chain variable region genes of microdissected marginal zone (MGZ) B cells suggests that the MGZ of human spleen is a reservoir of memory B cells","volume":"182","author":"Dunn-Walters","year":"1995","journal-title":"J Exp Med"},{"key":"R11-13-20210130","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/S0046-8177(98)80007-5","article-title":"Analysis of immunoglobulin genes in splenic marginal zone lymphoma suggests ongoing mutation","volume":"29","author":"Dunn-Walters","year":"1998","journal-title":"Hum Pathol"},{"key":"R12-13-20210130","doi-asserted-by":"crossref","first-page":"2464","DOI":"10.1182\/blood-2002-07-2216","article-title":"Splenic marginal zone lymphoma","volume":"101","author":"Franco","year":"2003","journal-title":"Blood"},{"key":"R13-13-20210130","doi-asserted-by":"crossref","first-page":"W435","DOI":"10.1093\/nar\/gkh412","article-title":"IMGT\/V-QUEST, an integrated software for immunoglobulin and T cell receptor V-J and V-D-J rearrangement analysis","volume":"32","author":"Giudicelli","year":"2004","journal-title":"Nucl Acids Res"},{"key":"R14-13-20210130","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/00000478-199605000-00008","article-title":"Splenic marginal zone lymphoma. A distinct B-cell neoplasm","volume":"20","author":"Hammer","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R15-13-20210130","doi-asserted-by":"crossref","first-page":"3835","DOI":"10.1200\/JCO.1999.17.12.3835","article-title":"World Health Organization classification of neoplastic diseases of the hematopoietic and lymphoid tissues: report of the Clinical Advisory Committee Meeting-Airlie House, Virginia, November 1997","volume":"17","author":"Harris","year":"1999","journal-title":"J Clin Oncol"},{"key":"R16-13-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1056\/NEJMoa013376","article-title":"Regression of splenic lymphoma with villous lymphocytes after treatment of hepatitis C virus infection","volume":"347","author":"Hermine","year":"2002","journal-title":"N Engl J Med"},{"key":"R17-13-20210130","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1182\/blood.V88.2.751.bloodjournal882751","article-title":"Splenic marginal zone lymphoma","volume":"88","author":"Isaacson","year":"1996","journal-title":"Blood"},{"key":"R18-13-20210130","doi-asserted-by":"crossref","first-page":"3828","DOI":"10.1182\/blood.V84.11.3828.bloodjournal84113828","article-title":"The histopathology of splenic lymphoma with villous lymphocytes","volume":"84","author":"Isaacson","year":"1994","journal-title":"Blood"},{"key":"R19-13-20210130","doi-asserted-by":"crossref","first-page":"4111","DOI":"10.4049\/jimmunol.164.8.4111","article-title":"Autoreactive B cells escape clonal deletion by expressing multiple antigen receptors","volume":"164","author":"Kenny","year":"2000","journal-title":"J Immunol"},{"key":"R20-13-20210130","doi-asserted-by":"crossref","first-page":"2501","DOI":"10.1126\/science.287.5462.2501","article-title":"T cell-independent rescue of B lymphocytes from peripheral immune tolerance","volume":"287","author":"Kouskoff","year":"2000","journal-title":"Science"},{"key":"R21-13-20210130","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1084\/jem.20022020","article-title":"Human immunoglobulin M memory B cells controlling Streptococcus pneumoniae infections are generated in the spleen","volume":"197","author":"Kruetzmann","year":"2003","journal-title":"J Exp Med"},{"key":"R22-13-20210130","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1038\/sj.leu.2402637","article-title":"IMGT\u00ae databases, web resources and tools for immunoglobulin and T cell receptor sequence analysis, http:\/\/imgt.cines.fr","volume":"17","author":"Lefranc","year":"2003","journal-title":"Leukemia"},{"key":"R23-13-20210130","doi-asserted-by":"crossref","first-page":"D593","DOI":"10.1093\/nar\/gki065","article-title":"IMGT, the international ImMunoGeneTics information system\u00ae","volume":"33","author":"Lefranc","year":"2005","journal-title":"Nucleic Acids Res"},{"key":"R24-13-20210130","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1034\/j.1600-065X.2003.00058.x","article-title":"Extrafollicular antibody responses","volume":"194","author":"MacLennan","year":"2003","journal-title":"Immunol Rev"},{"key":"R25-13-20210130","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1046\/j.1365-2559.2002.01360.x","article-title":"Marginal zone cell lymphoma--an update on recent advances","volume":"40","author":"Maes","year":"2002","journal-title":"Histopathology"},{"key":"R26-13-20210130","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1038\/nri799","article-title":"Marginal-zone B cells","volume":"2","author":"Martin","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"R27-13-20210130","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1038\/sj.leu.2402073","article-title":"Molecular heterogeneity of splenic marginal zone lymphomas: analysis of mutations in the 5\u2032 non-coding region of the bcl-6 gene","volume":"15","author":"Mateo","year":"2001","journal-title":"Leukemia"},{"key":"R28-13-20210130","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1146\/annurev.immunol.23.021704.115732","article-title":"Antigen-specific memory B cell development","volume":"23","author":"McHeyzer-Williams","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"R29-13-20210130","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1084\/jem.20040544","article-title":"Multiple distinct sets of stereotyped antigen receptors indicate a role for antigen in promoting chronic lymphocytic leukemia","volume":"200","author":"Messmer","year":"2004","journal-title":"J Exp Med"},{"key":"R30-13-20210130","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1097\/00000478-199510000-00005","article-title":"Splenic marginal zone lymphoma: a distinctive type of low-grade B-cell lymphoma. A clinicopathological study of 13 cases","volume":"19","author":"Mollejo","year":"1995","journal-title":"Am J Surg Pathol"},{"key":"R31-13-20210130","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1006\/clim.2001.5049","article-title":"The role of CD40-CD40 ligand (CD154) interactions in immunoglobulin light chain repertoire generation and somatic mutation","volume":"100","author":"Monson","year":"2001","journal-title":"Clin Immunol"},{"key":"R32-13-20210130","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1111\/j.0105-2896.2003.097.x","article-title":"Positive selection and lineage commitment during peripheral B-lymphocyte development","volume":"97","author":"Pillai","year":"2004","journal-title":"Immunol Rev"},{"key":"R33-13-20210130","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1146\/annurev.immunol.23.021704.115728","article-title":"Marginal zone B cells","volume":"23","author":"Pillai","year":"2005","journal-title":"Annu Rev Immunol"},{"key":"R34-13-20210130","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1097\/00000478-199602000-00010","article-title":"\u201cSmall\u201d B-cell non-Hodgkin's lymphomas with splenomegaly at presentation are either mantle cell lymphoma or marginal zone cell lymphoma. A study based on histology, cytology, immunohistochemistry, and cytogenetic analysis","volume":"20","author":"Pittaluga","year":"1996","journal-title":"Am J Surg Pathol"},{"key":"R35-13-20210130","doi-asserted-by":"crossref","first-page":"3777","DOI":"10.4049\/jimmunol.169.7.3777","article-title":"Evidence for involvement of a hydrophobic patch in framework region 1 of human V4-34-encoded Igs in recognition of the red blood cell I antigen","volume":"169","author":"Potter","year":"2002","journal-title":"J Immunol"},{"key":"R36-13-20210130","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0046-8177(95)90112-4","article-title":"Splenic marginal zone cell lymphoma: report of an indolent variant without massive splenomegaly presumably representing an early phase of the disease","volume":"26","author":"Rosso","year":"1995","journal-title":"Hum Pathol"},{"key":"R37-13-20210130","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1097\/00000478-199205000-00004","article-title":"Splenic marginal zone cell lymphoma","volume":"16","author":"Schmid","year":"1992","journal-title":"Am J Surg Pathol"},{"key":"R38-13-20210130","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1006\/bcmd.1996.0020","article-title":"The V4-34 encoded anti-i autoantibodies recognize a large subset of human and mouse B-cells","volume":"22","author":"Silberstein","year":"1996","journal-title":"Blood Cells Mol Dis"},{"key":"R39-13-20210130","first-page":"71","article-title":"Splenic marginal zone B-cell lymphomas: two cytogenetic subtypes, one with gain of 3q and the other with loss of 7q","volume":"86","author":"Sole","year":"2001","journal-title":"Haematologica"},{"key":"R40-13-20210130","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2119\/2005-00001.Stamatopoulos","article-title":"Immunoglobulin heavy- and light-chain repertoire in splenic marginal zone lymphoma","volume":"10","author":"Stamatopoulos","year":"2004","journal-title":"Mol Med"},{"key":"R41-13-20210130","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1182\/blood-2005-04-1511","article-title":"Immunoglobulin light chain repertoire in chronic lymphocytic leukemia","volume":"106","author":"Stamatopoulos","year":"2005","journal-title":"Blood"},{"key":"R42-13-20210130","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1182\/blood.V93.1.226","article-title":"Marginal-zone B cells in the human lymph node and spleen show somatic hypermutations and display clonal expansion","volume":"93","author":"Tierens","year":"1999","journal-title":"Blood"},{"key":"R43-13-20210130","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0002-9440(10)63862-X","article-title":"Splenic marginal zone lymphoma with villous lymphocytes shows on-going immunoglobulin gene mutations","volume":"162","author":"Tierens","year":"2003","journal-title":"Am J Pathol"},{"key":"R44-13-20210130","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1084\/jem.20011112","article-title":"Low-level hypermutation in T cell-independent germinal centers compared with high mutation rates associated with T cell-dependent germinal centers","volume":"195","author":"Toellner","year":"2002","journal-title":"J Exp Med"},{"key":"R45-13-20210130","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1097\/00000478-200012000-00001","article-title":"Splenic marginal zone lymphoma with or without plasmacytic differentiation","volume":"24","author":"Van Huyen","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"R46-13-20210130","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1073\/pnas.98.3.1166","article-title":"CD40-CD40L independent Ig gene hypermutation suggests a second B cell diversification pathway in humans","volume":"98","author":"Weller","year":"2001","journal-title":"Proc Natl Acad Sci USA"},{"key":"R47-13-20210130","doi-asserted-by":"crossref","first-page":"3647","DOI":"10.1182\/blood-2004-01-0346","article-title":"Human blood IgM \u201cmemory\u201d B cells are circulating splenic marginal zone B cells harboring a prediversified immunoglobulin repertoire","volume":"104","author":"Weller","year":"2004","journal-title":"Blood"},{"key":"R48-13-20210130","doi-asserted-by":"crossref","first-page":"95","DOI":"10.4049\/jimmunol.166.1.95","article-title":"Normal B cells express 51p1-encoded Ig heavy chains that are distinct from those expressed by chronic lymphocytic leukemia B cells","volume":"166","author":"Widhopf","year":"2001","journal-title":"J Immunol"},{"key":"R49-13-20210130","doi-asserted-by":"crossref","first-page":"2499","DOI":"10.1182\/blood-2004-03-0818","article-title":"Chronic lymphocytic leukemia B cells of more than 1% of patients express virtually identical immunoglobulins","volume":"104","author":"Widhopf","year":"2004","journal-title":"Blood"},{"key":"R50-13-20210130","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/ajcp\/105.3.277","article-title":"Splenic marginal zone cell lymphoma. An immunophenotypic and molecular study of five cases","volume":"105","author":"Wu","year":"1996","journal-title":"Am J Clin Pathol"},{"key":"R51-13-20210130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1046\/j.1365-2249.2002.01953.x","article-title":"The dual function of the splenic marginal zone: essential for initiation of anti-TI-2 responses but also vital in the general first-line defense against blood-borne antigens","volume":"130","author":"Zandvoort","year":"2002","journal-title":"Clin Exp Immunol"},{"key":"R52-13-20210130","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1182\/blood.V85.6.1603.bloodjournal8561603","article-title":"Splenic lymphoma with villous lymphocytes involves B cells with extensively mutated Ig heavy chain variable region genes","volume":"85","author":"Zhu","year":"1995","journal-title":"Blood"},{"key":"R53-13-20210130","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1182\/blood-2002-01-0169","article-title":"V(H)gene analysis of splenic marginal zone lymphomas reveals diversity in mutational status and initiation of somatic mutation in vivo","volume":"100","author":"Zhu","year":"2002","journal-title":"Blood"}],"container-title":["American Journal of Surgical Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/00000478-200703000-00013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:26:11Z","timestamp":1786033571000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00000478-200703000-00013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3]]},"references-count":53,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/01.pas.0000213419.08009.b0","relation":{},"ISSN":["0147-5185"],"issn-type":[{"value":"0147-5185","type":"print"}],"subject":[],"published":{"date-parts":[[2007,3]]}}}