{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T17:49:40Z","timestamp":1779299380185,"version":"3.51.4"},"reference-count":43,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1097\/01.psy.0000160465.79007.65","type":"journal-article","created":{"date-parts":[[2005,7,26]],"date-time":"2005-07-26T02:52:44Z","timestamp":1122346364000},"page":"590-595","source":"Crossref","is-referenced-by-count":6,"title":["Central Cholecystokinin Activity in Irritable Bowel Syndrome, Panic Disorder, and Healthy Controls"],"prefix":"10.1097","volume":"67","author":[{"given":"Diana","family":"Koszycki","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phane","family":"Torres","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James E.","family":"Swain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Bradwejn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"276","reference":[{"key":"R1-12-20210213","first-page":"470","article-title":"Can panic disorder present as irritable bowel syndrome?","volume":"47","author":"Lydiard","year":"1986","journal-title":"J Clin Psychiatry"},{"key":"R2-12-20210213","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1176\/ajp.147.5.565","article-title":"Irritable bowel syndrome and psychiatric illness.","volume":"147","author":"Walker","year":"1990","journal-title":"Am J Psychiatry"},{"key":"R3-12-20210213","doi-asserted-by":"crossref","first-page":"81","DOI":"10.3109\/10401239609148805","article-title":"The relationship between irritable bowel syndrome (IBS) and panic disorder.","volume":"8","author":"Kaplan","year":"1996","journal-title":"Ann Clin Psychiatry"},{"key":"R4-12-20210213","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1016\/0002-9343(92)90133-V","article-title":"Comorbidity of gastrointestinal complaints depression and anxiety in the Epidemiologic Catchment Area (ECA) study.","volume":"92","author":"Walker","year":"1992","journal-title":"Am J Med"},{"key":"R5-12-20210213","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1176\/ajp.151.1.64","article-title":"Panic disorder and gastrointestinal symptoms: findings from the NIMH epidemiologic catchment area project.","volume":"151","author":"Lydiard","year":"1994","journal-title":"Am J Psychiatry"},{"key":"R6-12-20210213","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3109\/10401239209149568","article-title":"The relationship between panic disorder and irritable bowel syndrome: a review.","volume":"4","author":"Woodman","year":"1992","journal-title":"Ann Clin Psychiatry"},{"key":"R7-12-20210213","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0447.1991.tb01416.x","article-title":"A comparison of the mental status, personality profiles and life events of patients with irritable bowel syndrome and peptic ulcer disease.","volume":"84","author":"Dinan","year":"1991","journal-title":"Acta Psychiatr Scand"},{"key":"R8-12-20210213","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/S0022-3999(03)00019-9","article-title":"Prevalence of irritable bowel syndrome among university students. The roles of worry, neuroticism, anxiety sensitivity and visceral anxiety.","volume":"55","author":"Hazlett-Stevens","year":"2003","journal-title":"J Psychosom Res"},{"key":"R9-12-20210213","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0033-3182(90)72220-7","article-title":"Reduction of gastrointestinal symptoms following treatment for panic disorder.","volume":"31","author":"Noyes","year":"1990","journal-title":"Psychosomatics"},{"key":"R10-12-20210213","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1365-2036.1994.tb00308.x","article-title":"Antidepressant therapy in 138 patients with irritable bowel syndrome: a five-year clinical experience.","volume":"8","author":"Clouse","year":"1994","journal-title":"Aliment Pharmacol Psychiatr Ther"},{"key":"R11-12-20210213","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1053\/gast.2003.50055","article-title":"The cost-effectiveness of psychotherapy and paroxetine for severe irritable bowel syndrome.","volume":"124","author":"Creed","year":"2003","journal-title":"Gastroenterology"},{"key":"R12-12-20210213","first-page":"175","article-title":"Anxiety and the gastrointestinal system.","volume":"8","author":"Fossey","year":"1990","journal-title":"Psychiatric Med"},{"key":"R13-12-20210213","first-page":"51","article-title":"Anxiety and the irritable bowel syndrome: psychiatric, medical, or both?","volume":"58","author":"Lydiard","year":"1997","journal-title":"J Clin Psychiatry"},{"key":"R14-12-20210213","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1177\/070674379003500115","article-title":"Cholecystokinin tetrapeptide induces panic attacks in patients with panic disorder.","volume":"35","author":"Bradwejn","year":"1990","journal-title":"Can J Psychiatry"},{"key":"R15-12-20210213","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1001\/archpsyc.1991.01810310021005","article-title":"Enhanced sensitivity of panic disorder to cholecystokinin-tetrapeptide: clinical and behavioral results.","volume":"48","author":"Bradwejn","year":"1991","journal-title":"Arch Gen Psychiatry"},{"key":"R16-12-20210213","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/0006-3223(92)90179-4","article-title":"A dose-ranging study of the behavioral and cardiovascular effects of CCK-4 in patients with panic disorder.","volume":"32","author":"Bradwejn","year":"1992","journal-title":"Biol Psychiatry"},{"key":"R17-12-20210213","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0006-3223(97)00249-7","article-title":"Cholecystokinin tetrapeptide-induced calcium mobilization in T cells of patients with panic disorder, major depression or schizophrenia.","volume":"42","author":"Akiyoshi","year":"1997","journal-title":"Biol Psychiatry"},{"key":"R18-12-20210213","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/sj.mp.4000507","article-title":"Investigation of CCK system genes in panic disorder.","volume":"4","author":"Kennedy","year":"1999","journal-title":"Mol Psychiatry"},{"key":"R19-12-20210213","first-page":"745","article-title":"International union of pharmacology XXI. Structure, distributions, and functions of cholecystokinin receptors.","volume":"51","author":"Noble","year":"2000","journal-title":"Pharmacol Rev"},{"key":"R20-12-20210213","doi-asserted-by":"crossref","first-page":"8691","DOI":"10.1073\/pnas.89.18.8691","article-title":"Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression.","volume":"89","author":"Wank","year":"1992","journal-title":"Proc Natl Acad Sci U S A"},{"key":"R21-12-20210213","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1176\/ajp.155.2.280","article-title":"The effects of cholecystokinin-tetrapeptide on respiratory function in healthy volunteers.","volume":"155","author":"Bradwejn","year":"1998","journal-title":"Am J Psychiatry"},{"key":"R22-12-20210213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1520-6394(1998)8:1<1::AID-DA1>3.0.CO;2-G","article-title":"Behavioural, cardiovascular and neuroendocrine profiles following CCK-4 challenge in healthy volunteers: a comparison of panickers and non-panickers.","volume":"8","author":"Koszycki","year":"1998","journal-title":"Dep Anx"},{"key":"R23-12-20210213","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/S0306-4530(00)00015-9","article-title":"Neurohormonal response to cholecystokinin-tetrapeptide: a comparison of younger and older healthy subjects.","volume":"25","author":"Flint","year":"2000","journal-title":"Psychoneuroendocrinology"},{"key":"R24-12-20210213","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1055\/s-2003-43047","article-title":"Acute effects of cholecystokinin-tetrapeptide on brain stem auditory evoked potentials in healthy volunteers.","volume":"36","author":"Gunnarsson","year":"2003","journal-title":"Pharmacopsychiatry"},{"key":"R25-12-20210213","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/hup.417","article-title":"Acute cholecystokinin effects on event-related potentials in healthy volunteers.","volume":"17","author":"Knott","year":"2002","journal-title":"J Hum Psychopharmacol"},{"key":"R26-12-20210213","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0278-5846(02)00350-0","article-title":"Effects of acute cholecystokinin infusion on hemispheric EEG asymmetry and coherence in healthy volunteers.","volume":"27","author":"Knott","year":"2003","journal-title":"Prog Neuro-Psychopharmacol Biol Psychiatry"},{"key":"R27-12-20210213","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/j.1749-6632.1994.tb44075.x","article-title":"The cholecystokinin hypothesis of panic disorder.","volume":"713","author":"Bradwejn","year":"1994","journal-title":"Ann NY Acad Sci"},{"key":"R28-12-20210213","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1176\/ajp.152.8.1180","article-title":"Functional neuroanatomy of CCK4-induced anxiety in normal healthy volunteers.","volume":"152","author":"Benkelfat","year":"1995","journal-title":"Am J Psychiatry"},{"key":"R29-12-20210213","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/S0006-3223(98)00348-5","article-title":"Neuroanatomical correlates of CCK-4-induced panic attacks in healthy humans: a time course study.","volume":"7","author":"Javanmard","year":"1999","journal-title":"Biol Psychiatry"},{"key":"R30-12-20210213","first-page":"RA55","article-title":"Irritable bowel syndrome: a model of the brain-gut interactions.","volume":"10","author":"Mulak","year":"2004","journal-title":"Med Sci Monit"},{"key":"R31-12-20210213","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1176\/ajp.148.2.277","article-title":"Role of cholecystokinin in irritable bowel syndrome.","volume":"148","author":"Bradwejn","year":"1991","journal-title":"Am J Psychiatry"},{"key":"R32-12-20210213","first-page":"89","article-title":"Abnormal CCK function: a pathophysiological model for panic disorder and gastrointestinal disorders? Evolving pathophysiological models of functional GI disorders: implications for new drug development.","author":"Bradwejn","year":"2000"},{"issue":"suppl 2","key":"R33-12-20210213","first-page":"II43","article-title":"Functional bowel disorders and functional abdominal pain.","volume":"45","author":"Thompson","year":"1999","journal-title":"Gut"},{"key":"R34-12-20210213","article-title":"Structured Clinical Interview for DSM-IV (patient and non-patient edition).","author":"First","year":"1995"},{"key":"R35-12-20210213","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1023\/A:1021904216312","article-title":"Anxiety and depressed are related to autonomic nervous system function in women with irritable bowel syndrome.","volume":"48","author":"Jarrett","year":"2003","journal-title":"Dig Dis Sci"},{"key":"R36-12-20210213","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/01.mcg.0000135362.35665.49","article-title":"Autonomic cardiovascular responses are impaired in women with irritable bowel syndrome.","volume":"38","author":"Waring","year":"2004","journal-title":"J Clin Gastroenterol"},{"key":"R37-12-20210213","first-page":"303","article-title":"Anxiety and autonomic flexibility: a cardiovascular approach.","volume":"49","author":"Friedman","year":"1998","journal-title":"Biol Psychology"},{"key":"R38-12-20210213","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1001\/archpsyc.1994.03950060050005","article-title":"The panicogenic effects of cholecystokinin-tetrapeptide are antagonised by L-356\u2013260, a central cholecystokinin receptor antagonists, in patients with panic disorder.","volume":"51","author":"Bradwejn","year":"1994","journal-title":"Arch Gen Psychiatry"},{"key":"R39-12-20210213","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/00004714-199512000-00007","article-title":"A double-blind, placebo-controlled study of a CCK-B receptor antagonist, CI-988, in patients with generalized anxiety disorder.","volume":"15","author":"Adams","year":"1995","journal-title":"J Clin Psychopharmacol"},{"key":"R40-12-20210213","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1038\/sj.bjp.0705769","article-title":"D\u2019Amato. Involvement of endogenous CCK and CCK1 receptors in colonic motor function.","volume":"8","author":"Varga","year":"2004","journal-title":"Br J Pharmacol"},{"key":"R41-12-20210213","first-page":"1433","article-title":"Cholecystokinin-A and cholecystokinin-B receptors in neurons of the brainstem solitary complex of the rat: pharmacological identification.","volume":"260","author":"Branchereau","year":"1992","journal-title":"J Pharmacol Exp Ther"},{"key":"R42-12-20210213","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1007\/BF00169136","article-title":"Opposite effects mediated by CCKA and CCKB receptors in behavioral and hormonal studies in rats.","volume":"349","author":"Mannisto","year":"1994","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"R43-12-20210213","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1136\/gut.2003.035642","article-title":"Brain imaging and functional gastrointestinal disorders: has it helped our understanding?","volume":"53","author":"Hobson","year":"2004","journal-title":"Gut"}],"container-title":["Psychosomatic Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.lww.com\/10.1097\/01.psy.0000160465.79007.65","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T17:51:41Z","timestamp":1735840301000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.lww.com\/00006842-200507000-00012"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2005]]}},"URL":"https:\/\/doi.org\/10.1097\/01.psy.0000160465.79007.65","relation":{},"ISSN":["0033-3174"],"issn-type":[{"value":"0033-3174","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}