{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T20:00:45Z","timestamp":1785787245951,"version":"3.56.0"},"reference-count":34,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2004,3,27]]},"DOI":"10.1097\/01.tp.0000110416.96307.d5","type":"journal-article","created":{"date-parts":[[2004,3,19]],"date-time":"2004-03-19T08:57:42Z","timestamp":1079686662000},"page":"804-812","source":"Crossref","is-referenced-by-count":22,"title":["Donor T cells lacking Fas ligand and perforin retain the capacity to induce severe GvHD in minor histocompatibility antigen mismatched bone-marrow transplantation recipients"],"prefix":"10.1097","volume":"77","author":[{"given":"Lianne","family":"Marks","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norman H.","family":"Altman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckhard R.","family":"Podack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert B.","family":"Levy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210129","first-page":"235","article-title":"T-cell depletion in allogeneic bone marrow transplantation: progress and problems","volume":"74","author":"Marmont","year":"1989","journal-title":"Haematologica"},{"key":"R2-4-20210129","doi-asserted-by":"crossref","first-page":"4079","DOI":"10.4049\/jimmunol.145.12.4079","article-title":"Immunodominance in the graft-vs-host disease T cell response to minor histocompatibility antigens","volume":"145","author":"Korngold","year":"1990","journal-title":"J Immunol"},{"key":"R3-4-20210129","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1084\/jem.183.6.2645","article-title":"The role of cell-mediated cytotoxicity in acute GVHD after MHC-matched allogeneic bone marrow transplantation in mice","volume":"183","author":"Baker","year":"1996","journal-title":"J Exp Med"},{"key":"R4-4-20210129","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1172\/JCI119606","article-title":"Perforin\/granzyme-dependent and independent mechanisms are both important for the development of graft-versus-host disease after murine bone marrow transplantation","volume":"100","author":"Graubert","year":"1997","journal-title":"J Clin Invest"},{"key":"R5-4-20210129","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1093\/intimm\/11.6.925","article-title":"Therapeutic effect of an anti-Fas ligand mAb on lethal graft-versus-host disease","volume":"11","author":"Miwa","year":"1999","journal-title":"Int Immunol"},{"key":"R6-4-20210129","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1182\/blood.V98.2.390","article-title":"Major histocompatibility complex-mismatched allogeneic bone marrow transplantation using perforin and\/or Fas ligand double-defective CD4(+) donor T cells: involvement of cytotoxic function by donor lymphocytes prior to graft-versus-host disease pathogenesis","volume":"98","author":"Jiang","year":"2001","journal-title":"Blood"},{"key":"R7-4-20210129","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1182\/blood.V94.2.390.414k27_390_400","article-title":"Massive activation-induced cell death of alloreactive T cells with apoptosis of bystander postthymic T cells prevents immune reconstitution in mice with graft-versus-host disease","volume":"94","author":"Brochu","year":"1999","journal-title":"Blood"},{"key":"R8-4-20210129","doi-asserted-by":"crossref","first-page":"2311","DOI":"10.4049\/jimmunol.166.4.2311","article-title":"Peripheral deletion after bone marrow transplantation with costimulatory blockade has features of both activation-induced cell death and passive cell death","volume":"166","author":"Wekerle","year":"2001","journal-title":"J Immunol"},{"key":"R10-4-20210129","doi-asserted-by":"crossref","first-page":"7063","DOI":"10.4049\/jimmunol.161.12.7063","article-title":"Perforin\/Fas-ligand double deficiency is associated with macrophage expansion and severe pancreatitis","volume":"161","author":"Spielman","year":"1998","journal-title":"J Immunol"},{"key":"R11-4-20210129","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1056\/NEJM199103073241005","article-title":"Graft-versus-host disease","volume":"324","author":"Ferrara","year":"1991","journal-title":"N Engl J Med"},{"key":"R12-4-20210129","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/S1083-8791(99)70011-X","article-title":"Pathophysiologic mechanisms of acute graft-vs.-host disease","volume":"5","author":"Ferrara","year":"1999","journal-title":"Biol Blood Marrow Transplant"},{"key":"R13-4-20210129","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1097\/00007890-199404150-00019","article-title":"T cell subsets involved in lethal graft-versus-host disease directed to immunodominant minor histocompatibility antigens","volume":"57","author":"Berger","year":"1994","journal-title":"Transplantation"},{"key":"R14-4-20210129","doi-asserted-by":"crossref","first-page":"51","DOI":"10.4049\/jimmunol.138.1.51","article-title":"Lethal graft-vs-host disease across major histocompatibility barriers: requirement for leucyl-leucine methyl ester sensitive cytotoxic T cells","volume":"138","author":"Thiele","year":"1987","journal-title":"J Immunol"},{"key":"R15-4-20210129","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood.V87.4.1232.bloodjournal8741232","article-title":"The role of granzyme B in murine models of acute graft-versus-host disease and graft rejection","volume":"87","author":"Graubert","year":"1996","journal-title":"Blood"},{"key":"R16-4-20210129","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1097\/00007890-199708270-00004","article-title":"CD4+ and CD8+ T cells each can utilize a perforin-dependent pathway to mediate lethal graft-versus-host disease in major histocompatibility complex-disparate recipients","volume":"64","author":"Blazar","year":"1997","journal-title":"Transplantation"},{"key":"R17-4-20210129","doi-asserted-by":"crossref","first-page":"4051","DOI":"10.1182\/blood.V91.11.4051","article-title":"Differential effects of anti-Fas ligand and anti-tumor necrosis factor alpha antibodies on acute graft-versus-host disease pathologies","volume":"91","author":"Hattori","year":"1998","journal-title":"Blood"},{"key":"R18-4-20210129","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S1083-8791(02)50028-8","article-title":"Leucyl-leucine methyl ester-treated haploidentical donor lymphocyte infusions can mediate graft-versus-leukemia activity with minimal graft-versus-host disease risk","volume":"8","author":"Hsieh","year":"2002","journal-title":"Biol Blood Marrow Transplant"},{"key":"R19-4-20210129","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1084\/jem.183.2.657","article-title":"Cytotoxic T cells deficient in both functional fas ligand and perforin show residual cytolytic activity yet lose their capacity to induce lethal acute graft-versus-host disease","volume":"183","author":"Braun","year":"1996","journal-title":"J Exp Med"},{"key":"R20-4-20210129","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.1182\/blood.V92.6.2177","article-title":"Involvement of donor T-cell cytotoxic effector mechanisms in preventing allogeneic marrow graft rejection","volume":"92","author":"Martin","year":"1998","journal-title":"Blood"},{"key":"R21-4-20210129","doi-asserted-by":"crossref","first-page":"2886","DOI":"10.1182\/blood.V97.9.2886","article-title":"Differential use of Fas ligand and perforin cytotoxic pathways by donor T cells in graft-versus-host disease and graft-versus-leukemia effect","volume":"97","author":"Schmaltz","year":"2001","journal-title":"Blood"},{"key":"R22-4-20210129","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1038\/nm0497-409","article-title":"Essential roles of the Fas ligand in the development of hepatitis","volume":"3","author":"Kondo","year":"1997","journal-title":"Nat Med"},{"key":"R23-4-20210129","doi-asserted-by":"crossref","first-page":"6654","DOI":"10.4049\/jimmunol.167.11.6654","article-title":"Liver damage by infiltrating CD8(+) T cells is Fas dependent","volume":"167","author":"Kennedy","year":"2001","journal-title":"J Immunol"},{"key":"R24-4-20210129","doi-asserted-by":"crossref","first-page":"5692","DOI":"10.4049\/jimmunol.158.12.5692","article-title":"Differential target cell sensitivity to CTL-activated death pathways in hepatitis B virus transgenic mice","volume":"158","author":"Nakamoto","year":"1997","journal-title":"J Immunol"},{"key":"R25-4-20210129","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00372294","article-title":"Immunodominance in the T-Cell response to multiple non-H-2 histocomptability antigens. II. Observation of a hierarchy among dominant antigens","volume":"24","author":"Wettstein","year":"1986","journal-title":"Immunogenetics"},{"key":"R26-4-20210129","first-page":"S71","article-title":"Role of marrow microenvironment in engraftment and maintenance of allogeneic hematopoietic stem cells","volume":"14","author":"Torok-Storb","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"R27-4-20210129","first-page":"183","article-title":"Paradigm shift for graft-versus-host disease","volume":"14","author":"Ferrara","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"R28-4-20210129","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1126\/science.290.5495.1354","article-title":"Regulation of antigen-specific CD8(+) T cell homeostasis by perforin and interferon-gamma","volume":"290","author":"Badovinac","year":"2000","journal-title":"Science"},{"key":"R29-4-20210129","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1038\/87720","article-title":"Memory CD8(+) T cell differentiation: initial antigen encounter triggers a developmental program in naive cells","volume":"2","author":"Kaech","year":"2001","journal-title":"Nat Immunol"},{"key":"R30-4-20210129","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/0167-5699(84)90126-9","article-title":"Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases","volume":"5","author":"Gleichmann","year":"1984","journal-title":"Immunol Today"},{"key":"R31-4-20210129","doi-asserted-by":"crossref","first-page":"5987","DOI":"10.4049\/jimmunol.165.10.5987","article-title":"Progression from acute to chronic disease in a murine parent-into-F(1) model of graft-versus-host disease","volume":"165","author":"Tschetter","year":"2000","journal-title":"J Immunol"},{"key":"R32-4-20210129","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1189\/jlb.70.5.756","article-title":"Activation-induced cell death of human T-cell subsets is mediated by Fas and granzyme B but is independent of TNF-alpha","volume":"70","author":"Gorak-Stolinska","year":"2001","journal-title":"J Leukoc Biol"},{"key":"R33-4-20210129","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1084\/jem.187.11.1903","article-title":"Aplastic anemia rescued by exhaustion of cytokine-secreting CD8(+) T cells in persistent infection with lymphocytic choriomeningitis virus","volume":"187","author":"Binder","year":"1998","journal-title":"J Exp Med"},{"key":"R34-4-20210129","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1128\/JVI.73.3.2527-2536.1999","article-title":"A role for perforin in downregulating T-cell responses during chronic viral infection","volume":"73","author":"Matloubian","year":"1999","journal-title":"J Virol"},{"key":"R35-4-20210129","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1126\/science.286.5446.1957","article-title":"Perforin gene defects in familiar hemophagocytic lymphohistiocytosis","volume":"286","author":"Stepp","year":"1999","journal-title":"Science"}],"container-title":["Transplantation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/01.TP.0000110416.96307.D5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T19:05:27Z","timestamp":1785783927000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00007890-200403270-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,3,27]]},"references-count":34,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004]]}},"URL":"https:\/\/doi.org\/10.1097\/01.tp.0000110416.96307.d5","relation":{},"ISSN":["0041-1337"],"issn-type":[{"value":"0041-1337","type":"print"}],"subject":[],"published":{"date-parts":[[2004,3,27]]}}}