{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:39:37Z","timestamp":1771490377004,"version":"3.50.1"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Neuropathol Exp Neurol"],"published-print":{"date-parts":[[2008,6]]},"DOI":"10.1097\/nen.0b013e318177eaf4","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T07:10:26Z","timestamp":1212131426000},"page":"523-531","source":"Crossref","is-referenced-by-count":127,"title":["Alzheimer Disease Pathology As a Host Response"],"prefix":"10.1093","volume":"67","author":[{"given":"Rudy J.","family":"Castellani","sequence":"first","affiliation":[]},{"given":"Hyoung-gon","family":"Lee","sequence":"additional","affiliation":[]},{"given":"Xiongwei","family":"Zhu","sequence":"additional","affiliation":[]},{"given":"George","family":"Perry","sequence":"additional","affiliation":[]},{"given":"Mark A.","family":"Smith","sequence":"additional","affiliation":[]}],"member":"286","published-online":{"date-parts":[[2008,6,1]]},"reference":[{"key":"2016030319050018000_67.6.523.1","unstructured":"Tomlinson BE . Ageing and the dementias. In: Greenfield JB Adams JH Duchen L , eds. Greenfield's Neuropathology , 5th ed, Oxford, UK: Oxford University Press, 1992:1284\u2013410"},{"key":"2016030319050018000_67.6.523.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04426.x"},{"key":"2016030319050018000_67.6.523.3","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nm0302-199b","article-title":"Setback to Alzheimer vaccine studies","volume":"8","author":"Birmingham","year":"2002","journal-title":"Nat Med"},{"key":"2016030319050018000_67.6.523.4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2006.04211.x"},{"key":"2016030319050018000_67.6.523.5","doi-asserted-by":"publisher","DOI":"10.1586\/14737175.7.5.473"},{"key":"2016030319050018000_67.6.523.6","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-006-0071-y"},{"key":"2016030319050018000_67.6.523.7","first-page":"146","article-title":"Uber eine eigenartige Erkrankung der Hirnrinde","volume":"64","author":"Alzheimer","year":"1907","journal-title":"Allgemeine Zeits Psychiat Psychisch-Gerichtlich Med"},{"key":"2016030319050018000_67.6.523.8","first-page":"415","article-title":"A study of neurofibrils in dementia paralytica, dementia senilis, chronic alcoholism, cerebral lues and microcephalic idiocy","volume":"63","author":"Fuller","year":"1907","journal-title":"Am J Insanity"},{"key":"2016030319050018000_67.6.523.9","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480130123013"},{"key":"2016030319050018000_67.6.523.10","doi-asserted-by":"publisher","DOI":"10.1002\/gps.930050603"},{"key":"2016030319050018000_67.6.523.11","unstructured":"Maurer K Maurer U . Alzheimer's Disease: The Life of a Physician and the Career of a Disease . Chichester, West Sussex, UK: Columbia University Press, 2003"},{"key":"2016030319050018000_67.6.523.12","unstructured":"Kraepelin E . Ein Lehrbuch fur Studierende und Arzte . Leipzig, Germany: Verlag von Johann Ambrosius Barth, 1910"},{"key":"2016030319050018000_67.6.523.13","first-page":"111","article-title":"The case described by Alois Alzheimer in 1911","volume":"248","author":"Moller","year":"1998","journal-title":"Historical and conceptual perspectives based on the clinical record and neurohistological sections. Eur Arch Psychiatry Clin Neurosci"},{"key":"2016030319050018000_67.6.523.14","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-196310000-00005"},{"key":"2016030319050018000_67.6.523.15","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/197192b0","article-title":"Paired helical filaments in electron microscopy of Alzheimer's disease","volume":"197","author":"Kidd","year":"1963","journal-title":"Nature"},{"key":"2016030319050018000_67.6.523.16","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1973.00490290064007"},{"key":"2016030319050018000_67.6.523.17","first-page":"6084","article-title":"Microtubule-associated protein tau","volume":"261","author":"Grundke-Iqbal","year":"1986","journal-title":"A component of Alzheimer paired helical filaments. J Biol Chem"},{"key":"2016030319050018000_67.6.523.18","doi-asserted-by":"publisher","DOI":"10.1126\/science.1900373"},{"key":"2016030319050018000_67.6.523.19","first-page":"80","article-title":"Alzheimer's disease","volume":"157","author":"Nash","year":"2001","journal-title":"New insights into its cause lead to new drug strategies. Time"},{"key":"2016030319050018000_67.6.523.20","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-007-7220-x"},{"key":"2016030319050018000_67.6.523.21","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M603469200"},{"key":"2016030319050018000_67.6.523.22","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2194"},{"key":"2016030319050018000_67.6.523.23","first-page":"261","article-title":"Pathological changed in the brain in dementia senilis","volume":"35","author":"Beljahow","year":"1889","journal-title":"J Mental Sci"},{"key":"2016030319050018000_67.6.523.24","first-page":"221","article-title":"Sur la signification des plaques seniles et sur la formule senile de l'ecorce cerebrale","volume":"31","author":"Simchowicz","year":"1924","journal-title":"Rev Neurol"},{"key":"2016030319050018000_67.6.523.25","doi-asserted-by":"publisher","DOI":"10.1007\/BF02866241"},{"key":"2016030319050018000_67.6.523.26","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000042088.22694.E3"},{"key":"2016030319050018000_67.6.523.27","doi-asserted-by":"publisher","DOI":"10.1086\/302702"},{"key":"2016030319050018000_67.6.523.28","first-page":"606","article-title":"Sur la structure des plaques dites seniles dans l'ecorce cerebrale des sujets ages et atteints d'affections mentales","volume":"70","author":"Marinesco","year":"1911","journal-title":"Comptes Rendus Seances Soc Biol Fil"},{"key":"2016030319050018000_67.6.523.29","first-page":"643","article-title":"Etude histo-chimique des plaques seniles","volume":"27","author":"Divry","year":"1927","journal-title":"J Belge Neurol Psychiatr"},{"key":"2016030319050018000_67.6.523.30","first-page":"553","article-title":"The ultrastructure of senile plaques","volume":"44","author":"Luse","year":"1964","journal-title":"Am J Pathol"},{"key":"2016030319050018000_67.6.523.31","doi-asserted-by":"publisher","DOI":"10.1016\/0006-291X(84)91209-9"},{"key":"2016030319050018000_67.6.523.32","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.12.4245"},{"key":"2016030319050018000_67.6.523.33","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(85)80078-2"},{"key":"2016030319050018000_67.6.523.34","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(89)90101-2"},{"key":"2016030319050018000_67.6.523.35","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199205000-00003"},{"key":"2016030319050018000_67.6.523.36","doi-asserted-by":"publisher","DOI":"10.1016\/0167-7799(93)90122-P"},{"key":"2016030319050018000_67.6.523.37","first-page":"7013","article-title":"Amyloid beta protein (A beta) in Alzheimer's disease brain","volume":"270","author":"Gravina","year":"1995","journal-title":"Biochemical and immunocytochemical analysis with antibodies specific for forms ending at A beta 40 or A beta 42(43). J Biol Chem"},{"key":"2016030319050018000_67.6.523.38","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410370303"},{"key":"2016030319050018000_67.6.523.39","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.57.5.713"},{"key":"2016030319050018000_67.6.523.40","first-page":"479","article-title":"The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)","volume":"41","author":"Mirra","year":"1991","journal-title":"Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology"},{"key":"2016030319050018000_67.6.523.41","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1985.04060100083029"},{"key":"2016030319050018000_67.6.523.42","doi-asserted-by":"publisher","DOI":"10.1007\/BF00308809"},{"key":"2016030319050018000_67.6.523.43","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(97)00057-2"},{"key":"2016030319050018000_67.6.523.44","doi-asserted-by":"publisher","DOI":"10.1126\/science.1113694"},{"key":"2016030319050018000_67.6.523.45","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2004.00865.x"},{"key":"2016030319050018000_67.6.523.46","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1789.2007.00766.x"},{"key":"2016030319050018000_67.6.523.47","doi-asserted-by":"publisher","DOI":"10.1038\/360672a0"},{"key":"2016030319050018000_67.6.523.48","doi-asserted-by":"publisher","DOI":"10.1126\/science.8424174"},{"key":"2016030319050018000_67.6.523.49","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03578.x"},{"key":"2016030319050018000_67.6.523.50","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20336"},{"key":"2016030319050018000_67.6.523.51","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.114009"},{"key":"2016030319050018000_67.6.523.52","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.91.25.12243"},{"key":"2016030319050018000_67.6.523.53","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199305000-00015"},{"key":"2016030319050018000_67.6.523.54","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-006-0575-6"},{"key":"2016030319050018000_67.6.523.55","doi-asserted-by":"publisher","DOI":"10.1007\/BF02755589"},{"key":"2016030319050018000_67.6.523.56","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M700192200"},{"key":"2016030319050018000_67.6.523.57","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.42.3.631"},{"key":"2016030319050018000_67.6.523.58","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000063311.58879.01"},{"key":"2016030319050018000_67.6.523.59","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540250089017"},{"key":"2016030319050018000_67.6.523.60","doi-asserted-by":"publisher","DOI":"10.1016\/0197-4580(92)90027-U"},{"key":"2016030319050018000_67.6.523.61","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.55.3.326"},{"key":"2016030319050018000_67.6.523.62","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1093\/jnen\/62.11.1087","article-title":"Neuropathology of cognitively normal elderly","volume":"62","author":"Knopman","year":"2003","journal-title":"J Neuropathol Exp Neurol"},{"key":"2016030319050018000_67.6.523.63","doi-asserted-by":"publisher","DOI":"10.1038\/nn1503"},{"key":"2016030319050018000_67.6.523.64","doi-asserted-by":"publisher","DOI":"10.1038\/nn0805-977"},{"key":"2016030319050018000_67.6.523.65","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65184-X"},{"key":"2016030319050018000_67.6.523.66","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(199912)46:6<860::AID-ANA8>3.0.CO;2-M"},{"key":"2016030319050018000_67.6.523.67","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7085"},{"key":"2016030319050018000_67.6.523.68","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200164200"},{"key":"2016030319050018000_67.6.523.69","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0600948103"},{"key":"2016030319050018000_67.6.523.70","doi-asserted-by":"publisher","DOI":"10.1038\/nature04533"},{"key":"2016030319050018000_67.6.523.71","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1046\/j.1471-4159.1998.70052212.x","article-title":"Amyloid-beta deposition in Alzheimer transgenic mice is associated with oxidative stress","volume":"70","author":"Smith","year":"1998","journal-title":"J Neurochem"},{"key":"2016030319050018000_67.6.523.72","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509695103"},{"key":"2016030319050018000_67.6.523.73","doi-asserted-by":"publisher","DOI":"10.1038\/nn0905-1136"},{"key":"2016030319050018000_67.6.523.74","doi-asserted-by":"publisher","DOI":"10.1126\/science.1105681"},{"key":"2016030319050018000_67.6.523.75","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2007.01.010"},{"key":"2016030319050018000_67.6.523.76","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199902000-00008"},{"key":"2016030319050018000_67.6.523.77","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)64296-4"},{"key":"2016030319050018000_67.6.523.78","doi-asserted-by":"publisher","DOI":"10.1097\/01.jnen.0000228136.58062.bf"},{"key":"2016030319050018000_67.6.523.79","doi-asserted-by":"publisher","DOI":"10.1097\/nen.0b013e31812503e1"},{"key":"2016030319050018000_67.6.523.80","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(96)09328-2"},{"key":"2016030319050018000_67.6.523.81","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1551"},{"key":"2016030319050018000_67.6.523.82","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2007040444"},{"key":"2016030319050018000_67.6.523.83","unstructured":"Bielschowsky M . Histopathology of nerve cells. In: Wilder P , eds. Cytology and Cellular Pathology of the Nervous System , Montreal, Canada: Paul B. Hoeber, Inc., 1932:103"}],"container-title":["Journal of Neuropathology &amp; Experimental Neurology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T18:50:23Z","timestamp":1557600623000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jnen\/article-lookup\/doi\/10.1097\/NEN.0b013e318177eaf4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,6]]},"references-count":83,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2008,6,1]]},"published-print":{"date-parts":[[2008,6]]}},"alternative-id":["10.1097\/NEN.0b013e318177eaf4"],"URL":"https:\/\/doi.org\/10.1097\/nen.0b013e318177eaf4","relation":{},"ISSN":["0022-3069","1554-6578"],"issn-type":[{"value":"0022-3069","type":"print"},{"value":"1554-6578","type":"electronic"}],"subject":[],"published":{"date-parts":[[2008,6]]}}}