{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,18]],"date-time":"2026-10-18T21:06:16Z","timestamp":1792357576600,"version":"4.4.0"},"reference-count":46,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2007,8]]},"DOI":"10.1097\/aci.0b013e3282370c5f","type":"journal-article","created":{"date-parts":[[2007,7,9]],"date-time":"2007-07-09T04:07:31Z","timestamp":1183954051000},"page":"317-323","source":"Crossref","is-referenced-by-count":152,"title":["Human leukocyte antigens and drug hypersensitivity"],"prefix":"10.1097","volume":"7","author":[{"given":"Wen-Hung","family":"Chung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuen-Iu","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan-Tsong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210128","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1097\/01.all.0000173785.81024.33","article-title":"Epidemiology of hypersensitivity drug reactions","volume":"5","author":"Gomes","year":"2005","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R2-6-20210128","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.tox.2004.12.022","article-title":"Clinical heterogeneity of drug hypersensitivity","volume":"209","author":"Roujeau","year":"2005","journal-title":"Toxicology"},{"key":"R3-6-20210128","doi-asserted-by":"crossref","first-page":"889","DOI":"10.2217\/14622416.7.6.889","article-title":"Can pharmacogenetics help rescue drugs withdrawn from the market?","volume":"7","author":"Shah","year":"2006","journal-title":"Pharmacogenomics"},{"key":"R4-6-20210128","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2332\/allergolint.55.27","article-title":"Immune mechanisms in drug allergy","volume":"55","author":"Roujeau","year":"2006","journal-title":"Allergol Int"},{"key":"R5-6-20210128","doi-asserted-by":"crossref","first-page":"17","DOI":"10.2332\/allergolint.55.17","article-title":"Pharmacological interaction of drugs with immune receptors: the p-i concept","volume":"55","author":"Pichler","year":"2006","journal-title":"Allergol Int"},{"key":"R6-6-20210128","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1136\/pgmj.75.889.680","article-title":"Concordance of primary generalised epilepsy and carbamazepine hypersensitivity in monozygotic twins","volume":"75","author":"Edwards","year":"1999","journal-title":"Postgrad Med J"},{"key":"R7-6-20210128","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1111\/j.1365-2125.1992.tb05647.x","article-title":"Idiosyncratic drug reactions: a mechanistic evaluation of risk factors","volume":"34","author":"Park","year":"1992","journal-title":"Br J Clin Pharmacol"},{"key":"R8-6-20210128","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.23.021704.115658","article-title":"How TCRs bind MHCs, peptides, and coreceptors","volume":"24","author":"Rudolph","year":"2006","journal-title":"Annu Rev Immunol"},{"key":"R9-6-20210128","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1038\/nrg1489","article-title":"Gene map of the extended human MHC","volume":"5","author":"Horton","year":"2004","journal-title":"Nat Rev Genet"},{"key":"R11-6-20210128","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.1056\/NEJM199012273232607","article-title":"Bone marrow-allograft rejection by T lymphocytes recognizing a single amino acid difference in HLA-B44","volume":"323","author":"Fleischhauer","year":"1990","journal-title":"N Engl J Med"},{"key":"R12-6-20210128","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/archderm.1987.01660330082014","article-title":"Genetic susceptibility to toxic epidermal necrolysis","volume":"123","author":"Roujeau","year":"1987","journal-title":"Arch Dermatol"},{"key":"R13-6-20210128","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/archopht.1997.01100150552021","article-title":"Stevens-Johnson syndrome induced by methazolamide treatment","volume":"115","author":"Shirato","year":"1997","journal-title":"Arch Ophthalmol"},{"key":"R14-6-20210128","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1159\/000248097","article-title":"HLA and allopurinol drug eruption","volume":"179","author":"Chan","year":"1989","journal-title":"Dermatologica"},{"key":"R15-6-20210128","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1001\/archpsyc.1990.01810220061007","article-title":"HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia","volume":"47","author":"Lieberman","year":"1990","journal-title":"Arch Gen Psychiatry"},{"key":"R16-6-20210128","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1097\/00008571-199602000-00005","article-title":"Genetic factors and risk of agranulocytosis from metamizol","volume":"6","author":"Vlahov","year":"1996","journal-title":"Pharmacogenetics"},{"key":"R17-6-20210128","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/0167-5699(90)90109-M","article-title":"HLA-B27 and agranulocytosis by levamisole","volume":"11","author":"Diez","year":"1990","journal-title":"Immunol Today"},{"key":"R18-6-20210128","first-page":"41","article-title":"Association of HLA-DR5 with mucocutaneous lesions in patients with rheumatoid arthritis receiving gold sodium thiomalate","volume":"21","author":"Rodriguez-Perez","year":"1994","journal-title":"J Rheumatol"},{"key":"R19-6-20210128","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0140-6736(80)91554-8","article-title":"Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility","volume":"1","author":"Batchelor","year":"1980","journal-title":"Lancet"},{"key":"R20-6-20210128","first-page":"948","article-title":"HLA-DR antigens and proteinuria induced by aurothioglucose and D-penicillamine in patients with rheumatoid arthritis","volume":"10","author":"Speerstra","year":"1983","journal-title":"J Rheumatol"},{"key":"R21-6-20210128","doi-asserted-by":"crossref","first-page":"225","DOI":"10.2217\/17410541.2.3.225","article-title":"HLA-B genotyping to detect carbamazepine-induced Stevens-Johnson syndrome: implications for personalizing medicine","volume":"2","author":"Hung","year":"2005","journal-title":"Personalized Medicine"},{"key":"R22-6-20210128","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/428486a","article-title":"Medical genetics: a marker for Stevens-Johnson syndrome","volume":"428","author":"Chung","year":"2004","journal-title":"Nature"},{"key":"R23-6-20210128","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","article-title":"Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions","volume":"16","author":"Hung","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"R24-6-20210128","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.tpj.6500356","article-title":"A marker for Stevens-Johnson syndrome \u2026: ethnicity matters","volume":"6","author":"Lonjou","year":"2006","journal-title":"Pharmacogenomics J"},{"key":"R25-6-20210128","doi-asserted-by":"crossref","first-page":"813","DOI":"10.2217\/14622416.7.6.813","article-title":"HLA-B locus in Caucasian patients with carbamazepine hypersensitivity","volume":"7","author":"Alfirevic","year":"2006","journal-title":"Pharmacogenomics"},{"key":"R26-6-20210128","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1517\/phgs.5.2.203.27481","article-title":"Association of genetic variations in HLA-B region with hypersensitivity to abacavir in some, but not all, populations","volume":"5","author":"Hughes","year":"2004","journal-title":"Pharmacogenomics"},{"key":"R27-6-20210128","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/nrg1559","article-title":"Pharmacogenetics and geographical ancestry: implications for drug development and global health","volume":"6","author":"Daar","year":"2005","journal-title":"Nat Rev Genet"},{"key":"R28-6-20210128","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1212\/WNL.56.7.890","article-title":"TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients","volume":"56","author":"Pirmohamed","year":"2001","journal-title":"Neurology"},{"key":"R29-6-20210128","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1097\/01.fpc.0000189800.88596.7a","article-title":"Serious carbamazepine-induced hypersensitivity reactions associated with the HSP70 gene cluster","volume":"16","author":"Alfirevic","year":"2006","journal-title":"Pharmacogenet Genomics"},{"key":"R31-6-20210128","doi-asserted-by":"crossref","first-page":"4134","DOI":"10.1073\/pnas.0409500102","article-title":"HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol","volume":"102","author":"Hung","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"R34-6-20210128","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/S0140-6736(02)07873-X","article-title":"Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir","volume":"359","author":"Mallal","year":"2002","journal-title":"Lancet"},{"key":"R35-6-20210128","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/S0140-6736(02)08158-8","article-title":"Genetic variations in HLA-B region and hypersensitivity reactions to abacavir","volume":"359","author":"Hetherington","year":"2002","journal-title":"Lancet"},{"key":"R36-6-20210128","doi-asserted-by":"crossref","first-page":"4180","DOI":"10.1073\/pnas.0307067101","article-title":"Predisposition to abacavir hypersensitivity conferred by HLA-B*5701 and a haplotypic Hsp70-Hom variant","volume":"101","author":"Martin","year":"2004","journal-title":"Proc Natl Acad Sci USA"},{"key":"R37-6-20210128","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1086\/504878","article-title":"Genetic screening to prevent abacavir hypersensitivity reaction: are we there yet?","volume":"43","author":"Phillips","year":"2006","journal-title":"Clin Infect Dis"},{"key":"R38-6-20210128","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1086\/504874","article-title":"Prospective genetic screening decreases the incidence of abacavir hypersensitivity reactions in the Western Australian HIV cohort study","volume":"43","author":"Rauch","year":"2006","journal-title":"Clin Infect Dis"},{"key":"R39-6-20210128","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00002030-200501030-00014","article-title":"Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts","volume":"19","author":"Martin","year":"2005","journal-title":"AIDS"},{"key":"R40-6-20210128","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1097\/01.aids.0000238408.82947.09","article-title":"HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients","volume":"20","author":"Littera","year":"2006","journal-title":"AIDS"},{"key":"R41-6-20210128","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1111\/j.1365-2222.2004.02197.x","article-title":"The human leucocyte antigen-DRB1*1302-DQB1*0609-DPB1*0201 haplotype may be a strong genetic marker for aspirin-induced urticaria","volume":"35","author":"Kim","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"R42-6-20210128","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/01.all.0000235899.57182.d4","article-title":"Genetic mechanism of aspirin-induced urticaria\/angioedema","volume":"6","author":"Kim","year":"2006","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R43-6-20210128","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.ajo.2006.09.029","article-title":"Strong association between HLA-A*0206 and Stevens-Johnson syndrome in the Japanese","volume":"143","author":"Ueta","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"R44-6-20210128","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.tox.2004.12.026","article-title":"Diagnosis of drug hypersensitivity: lymphocyte transformation test and cytokines","volume":"209","author":"Merk","year":"2005","journal-title":"Toxicology"},{"key":"R45-6-20210128","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1016\/j.jaci.2004.07.047","article-title":"Toxic epidermal necrolysis: effector cells are drug-specific cytotoxic T cells","volume":"114","author":"Nassif","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"R46-6-20210128","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1172\/JCI119505","article-title":"Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones","volume":"100","author":"Schnyder","year":"1997","journal-title":"J Clin Invest"},{"key":"R47-6-20210128","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jaci.2006.03.005","article-title":"Activation of T cells by carbamazepine and carbamazepine metabolites","volume":"118","author":"Wu","year":"2006","journal-title":"J Allergy Clin Immunol"},{"key":"R48-6-20210128","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0167-5699(98)80012-1","article-title":"Allergic and autoimmune reactions to xenobiotics: how do they arise?","volume":"19","author":"Griem","year":"1998","journal-title":"Immunol Today"},{"key":"R49-6-20210128","doi-asserted-by":"crossref","first-page":"3327","DOI":"10.2174\/138161206778194042","article-title":"Immediate hypersensitivity reactions to penicillins and other betalactams","volume":"12","author":"Antunez","year":"2006","journal-title":"Curr Pharm Des"},{"key":"R50-6-20210128","doi-asserted-by":"crossref","first-page":"E160","DOI":"10.1208\/aapsj080119","article-title":"Noncovalent interactions of drugs with immune receptors may mediate drug-induced hypersensitivity reactions","volume":"8","author":"Gerber","year":"2006","journal-title":"AAPS J"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e3282370c5f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T16:40:43Z","timestamp":1786034443000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-200708000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8]]},"references-count":46,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e3282370c5f","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2007,8]]}}}