{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:12:43Z","timestamp":1786119163978,"version":"build-2736575974"},"reference-count":53,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2008,2]]},"DOI":"10.1097\/aci.0b013e3282f3f44f","type":"journal-article","created":{"date-parts":[[2009,3,5]],"date-time":"2009-03-05T00:17:16Z","timestamp":1236212236000},"page":"28-33","source":"Crossref","is-referenced-by-count":34,"title":["Laryngopharyngeal reflux: diagnosis and treatment of a controversial disease"],"prefix":"10.1097","volume":"8","author":[{"given":"Mahmoud El-Sayed","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-6-20210128","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1067\/mhn.2002.125760","article-title":"Laryngopharyngeal reflux: position statement of the Committee on Speech, Voice, and Swallowing Disorders of the American Academy of Otolaryngology\u2013Head and Neck Surgery","volume":"127","author":"Koufman","year":"2002","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"suppl 53","key":"R2-6-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/lary.1991.101.s53.1","article-title":"The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24-h pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury","volume":"101","author":"Koufman","year":"1991","journal-title":"Laryngoscope"},{"key":"R3-6-20210128","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1097\/01.MLG.0000201907.24514.6A","article-title":"Helicobacter pylori seropositivity predicts outcomes of acid suppression therapy for laryngopharyngeal reflux symptoms","volume":"116","author":"Oridate","year":"2006","journal-title":"Laryngoscope"},{"key":"R4-6-20210128","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1067\/mhn.2001.114256","article-title":"Occult laryngeal pathology in a community-based cohort","volume":"124","author":"Reulbach","year":"2001","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R5-6-20210128","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0892-1997(02)00132-7","article-title":"The prevalence of hypopharyngeal findings associated with gastroesophageal reflux in normal volunteers","volume":"16","author":"Hicks","year":"2002","journal-title":"J Voice"},{"key":"R6-6-20210128","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1097\/01.mlg.0000149445.07146.03","article-title":"Pepsin and carbonic anhydrase isoenzyme III as diagnostic markers for laryngopharyngeal reflux disease","volume":"114","author":"Johnston","year":"2004","journal-title":"Laryngoscope"},{"key":"R7-6-20210128","first-page":"A1918","article-title":"Pepsin activity in sputum suggests new criteria for supraoesophageal pH probes","volume":"49","author":"Panetti","year":"2001","journal-title":"Gut"},{"key":"R8-6-20210128","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1080\/00016480500529314","article-title":"Laryngopharyngeal reflux finding scores correlate with gastroesophageal reflux disease and Helicobacter pylori expression","volume":"126","author":"Tezer","year":"2006","journal-title":"Acta Otolaryngol"},{"key":"R9-6-20210128","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.otohns.2006.03.020","article-title":"The role of gastric Helicobacter pylori infection in laryngopharyngeal reflux disease","volume":"135","author":"Ercan","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R10-6-20210128","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1080\/00016480410022499","article-title":"Gastroesophageal reflux and sequelae of chronic tubotympanal disorders in children","volume":"124","author":"Velepic","year":"2004","journal-title":"Acta Otolaryngol"},{"key":"R11-6-20210128","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1080\/000164802753648213","article-title":"Laryngeal manifestations of gastroesophageal reflux disease in children","volume":"122","author":"Zalesska-Krecicka","year":"2002","journal-title":"Acta Otolaryngol"},{"key":"R12-6-20210128","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1097\/00005537-200206000-00004","article-title":"Gastroesophageal reflux and Eustachian tube dysfunction in an animal model","volume":"112","author":"White","year":"2002","journal-title":"Laryngoscope"},{"key":"R13-6-20210128","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1097\/00005537-200211000-00004","article-title":"Is gastric reflux a cause of otitis media with effusion in children?","volume":"112","author":"Tasker","year":"2002","journal-title":"Laryngoscope"},{"key":"R14-6-20210128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.otohns.2006.08.024","article-title":"Otitis media in adults as a symptom of gastroesophageal reflux","volume":"136","author":"Sone","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R15-6-20210128","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.otohns.2006.08.030","article-title":"Pepsin assay: a marker for reflux in pediatric glue ear","volume":"136","author":"Abd El-Fattah","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R16-6-20210128","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1097\/00005537-199704000-00014","article-title":"Long term outcome analysis of functional endoscopic sinus surgery: correlation of symptoms with endoscopic examination findings and potential prognostic factors","volume":"107","author":"Chambers","year":"1997","journal-title":"Laryngoscope"},{"key":"R17-6-20210128","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/S0030-6665(05)70244-9","article-title":"Laryngopharyngeal reflux: state of the art diagnosis and treatment","volume":"33","author":"Ulualp","year":"2000","journal-title":"Otolaryngol Clin North Am"},{"key":"R18-6-20210128","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.7326\/0003-4819-129-12-199812150-00029","article-title":"Sinusitis and gastroesophageal reflux disease","volume":"129","author":"DiBaise","year":"1998","journal-title":"Ann Intern Med"},{"key":"R19-6-20210128","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/S0194-5998(99)70181-6","article-title":"Outcome of reflux therapy on pediatric chronic sinusitis","volume":"1221","author":"Bothwell","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R20-6-20210128","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1097\/01.MLG.0000163751.00885.63","article-title":"Direct nasopharyngeal reflux of gastric acid is a contributing factor in refractory chronic rhinosinusitis","volume":"115","author":"DelJaudio","year":"2005","journal-title":"Laryngoscope"},{"key":"R21-6-20210128","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1097\/MLG.0b013e3180330081","article-title":"Flexible laryngoscopy-guided pharyngeal pH monitoring in infants","volume":"117","author":"Ulualp","year":"2007","journal-title":"Laryngoscope"},{"key":"R22-6-20210128","first-page":"1503","article-title":"Chronic hoarseness secondary to gastroesophageal reflux disease: documentation with 24-h ambulatory pH monitoring","volume":"84","author":"Wiener","year":"1989","journal-title":"Am J Gastroenterol"},{"key":"R23-6-20210128","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1177\/0003489400109S1003","article-title":"Ambulatory pH monitoring methodology","volume":"109","author":"Postma","year":"2000","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"R24-6-20210128","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/MLG.0b013e31802d344c","article-title":"Exclusion of pH artifacts is essential for hypopharyngeal pH monitoring","volume":"117","author":"Harrell","year":"2007","journal-title":"Laryngoscope"},{"key":"R25-6-20210128","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1097\/00005537-199802000-00027","article-title":"Ambulatory pH measurements at the upper esophageal sphincter","volume":"108","author":"Smit","year":"1998","journal-title":"Laryngoscope"},{"key":"R26-6-20210128","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1097\/00005537-200112000-00013","article-title":"Evaluation of omeprazole in the treatment of reflux laryngitis: a prospective, placebo-controlled, randomized, double-blind study","volume":"111","author":"Noordzij","year":"2001","journal-title":"Laryngoscope"},{"key":"R27-6-20210128","doi-asserted-by":"crossref","first-page":"2192","DOI":"10.1097\/00005537-200212000-00013","article-title":"Correlation of pH probe-measured laryngopharyngeal reflux with symptoms and signs of reflux laryngitis","volume":"112","author":"Noordzij","year":"2002","journal-title":"Laryngoscope"},{"key":"R28-6-20210128","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/S0892-1997(00)80033-8","article-title":"The proximal probe in esophageal pH monitoring: development of a normative database","volume":"14","author":"Vincent","year":"2000","journal-title":"J Voice"},{"key":"R29-6-20210128","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1007\/s00405-006-0097-8","article-title":"Hoarseness and laryngopharyngeal reflux: a cause and effect relationship or coincidence?","volume":"263","author":"Ozturk","year":"2006","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R30-6-20210128","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/00005537-200110000-00013","article-title":"Symptoms, laryngeal findings, and 24-h pH monitoring in patients with suspected gastroesophago-pharyngeal reflux","volume":"111","author":"Ylitalo","year":"2001","journal-title":"Laryngoscope"},{"key":"R31-6-20210128","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1023\/B:DDAS.0000043372.98660.82","article-title":"Proximal sensor data from routine dual-sensor esophageal pH monitoring is often inaccurate","volume":"49","author":"McCollough","year":"2004","journal-title":"Dig Dis Sci"},{"key":"R32-6-20210128","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/01.mlg.0000150696.54000.a2","article-title":"Design and implementation of an ambulatory pH monitoring protocol in patients with suspected laryngopharyngeal reflux","volume":"115","author":"Harrell","year":"2005","journal-title":"Laryngoscope"},{"key":"R33-6-20210128","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1097\/01.mlg.0000192173.00498.ba","article-title":"Treatment of chronic posterior laryngitis with esomeprazole","volume":"116","author":"Vaezi","year":"2006","journal-title":"Laryngoscope"},{"key":"R34-6-20210128","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1111\/j.1572-0241.2005.41719.x","article-title":"Comparison of the Bravo wireless and Digitrapper catheter-based pH monitoring systems for measuring esophageal acid exposure","volume":"100","author":"Pandolfino","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"R35-6-20210128","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1097\/00005537-200208000-00014","article-title":"Perspectives in laryngopharyngeal reflux: an international survey","volume":"112","author":"Book","year":"2002","journal-title":"Laryngoscope"},{"key":"R36-6-20210128","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s00405-006-0222-8","article-title":"Trends in laryngopharyngeal reflux: a British ENT survey","volume":"264","author":"Karkos","year":"2007","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"R37-6-20210128","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.otohns.2006.12.004","article-title":"Reflux and laryngitis: a systematic review","volume":"136","author":"Joniau","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R38-6-20210128","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1542\/peds.88.4.834","article-title":"Gastroesophageal reflux, as measured by 24-h pH monitoring in 509 healthy infants screened for risk of sudden infant death syndrome","volume":"88","author":"Vandenplas","year":"1991","journal-title":"Pediatrics"},{"key":"R39-6-20210128","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1097\/00005537-200108000-00001","article-title":"The validity and reliability of the reflux finding score (RFS)","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"R40-6-20210128","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/S0892-1997(02)00097-8","article-title":"Validity and reliability of the reflux symptom index (RSI)","volume":"16","author":"Belafsky","year":"2002","journal-title":"J Voice"},{"key":"R41-6-20210128","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.otohns.2006.05.012","article-title":"Gastroesophageal reflux and laryngopharyngeal reflux in patients with sleep-disordered breathing","volume":"135","author":"Wise","year":"2006","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R42-6-20210128","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jvoice.2005.09.004","article-title":"Reliability of speech-language pathologist and otolaryngologist ratings of laryngeal signs of reflux in an asymptomatic population using the Reflux Finding Score","volume":"21","author":"Kelchner","year":"2007","journal-title":"J Voice"},{"key":"R43-6-20210128","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1097\/01.mlg.0000176547.90094.ac","article-title":"Correlation between symptoms and laryngeal signs in laryngopharyngeal reflux","volume":"115","author":"Qadeer","year":"2005","journal-title":"Laryngoscope"},{"key":"R44-6-20210128","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/01.mlg.0000191463.67692.36","article-title":"Empiric treatment of laryngopharyngeal reflux with proton pump inhibitors: a systematic review","volume":"116","author":"Karkos","year":"2006","journal-title":"Laryngoscope"},{"key":"R45-6-20210128","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1097\/00005537-200206000-00016","article-title":"The reliability of the assessment of endoscopic laryngeal findings associated with laryngopharyngeal reflux disease","volume":"112","author":"Branski","year":"2002","journal-title":"Laryngoscope"},{"key":"R46-6-20210128","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/j.1749-4486.2006.01134.x","article-title":"A systematic review of the rule of proton pump inhibitors for symptoms of laryngopharyngeal reflux","volume":"31","author":"Sen","year":"2006","journal-title":"Clin Otolaryngol"},{"key":"R47-6-20210128","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1080\/00016480600606665","article-title":"An effective management regimen for laryngeal granuloma caused by gastro-esophageal reflux: combination therapy with suggestions for lifestyle modifications","volume":"127","author":"Tsunoda","year":"2007","journal-title":"Acta Otolaryngol"},{"key":"R48-6-20210128","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1097\/01.MLG.0000163746.81766.45","article-title":"Laryngopharyngeal reflux: prospective cohort study evaluating optimal dose of proton-pump inhibitor therapy and pretherapy predictors of response","volume":"115","author":"Park","year":"2005","journal-title":"Laryngoscope"},{"key":"R49-6-20210128","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1097\/00005537-200304000-00003","article-title":"Empiric esomeprazole in the treatment of laryngopharyngeal reflux","volume":"113","author":"DelGaudio","year":"2002","journal-title":"Laryngoscope"},{"key":"R50-6-20210128","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1097\/00005537-200106000-00009","article-title":"Laryngopharyngeal reflux symptoms improve before changes in physical findings","volume":"111","author":"Belafsky","year":"2001","journal-title":"Laryngoscope"},{"key":"R51-6-20210128","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.otohns.2006.10.011","article-title":"Efficacy of once-daily esomeprazole treatment in patients with laryngopharyngeal reflux evaluated by 24-h pH monitoring","volume":"136","author":"Reichel","year":"2007","journal-title":"Otolaryngol Head Neck Surg"},{"key":"R52-6-20210128","doi-asserted-by":"crossref","first-page":"1981","DOI":"10.1053\/gast.1996.1101981","article-title":"Medical position statement: guidelines on the use of esophageal pH recording.","volume":"110","year":"1996","journal-title":"Gastroenterology"},{"key":"R53-6-20210128","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1378\/chest.06-1312","article-title":"Acidic and nonacidic reflux during sleep under conditions of powerful acid suppression","volume":"131","author":"Orr","year":"2007","journal-title":"Chest"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e3282f3f44f","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:53:43Z","timestamp":1786038823000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-200802000-00006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,2]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e3282f3f44f","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2008,2]]}}}