{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T16:14:19Z","timestamp":1786119259880,"version":"build-2736575974"},"reference-count":37,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1097\/aci.0b013e32832ac00b","type":"journal-article","created":{"date-parts":[[2009,5,21]],"date-time":"2009-05-21T12:57:23Z","timestamp":1242910643000},"page":"190-196","source":"Crossref","is-referenced-by-count":17,"title":["Long-term outcomes of early childhood wheezing"],"prefix":"10.1097","volume":"9","author":[{"given":"Eija","family":"Piippo-Savolainen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matti","family":"Korppi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-4-20210128","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1067\/mai.2003.162","article-title":"Tucson Children's Respiratory Study: 1980 to present. Review","volume":"111","author":"Taussig","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"R2-4-20210128","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.1651-2227.2007.00558.x","article-title":"Wheezy babies: wheezy adults? Review on long-term outcome until adulthood after early childhood wheezing","volume":"97","author":"Piippo-Savolainen","year":"2008","journal-title":"Acta Paediatr"},{"key":"R3-4-20210128","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1164\/rccm.200603-435PP","article-title":"Bronchiolitis to asthma: a review and call for studies of gene\u2013virus interactions in asthma causation","volume":"175","author":"Singh","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"R5-4-20210128","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1056\/NEJM199501193320301","article-title":"Asthma and wheezing in the first six years of life. The Group Health Medical Associates","volume":"332","author":"Martinez","year":"1995","journal-title":"N Engl J Med"},{"key":"R6-4-20210128","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1136\/bmj.312.7040.1195","article-title":"Incidence and prognosis of asthma and wheezing illness from early childhood to age 33 in a national British cohort","volume":"312","author":"Strachan","year":"1996","journal-title":"BMJ"},{"key":"R7-4-20210128","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S1081-1206(10)60879-4","article-title":"Asthma onset and relapse in adult life: the British 1958 birth cohort study","volume":"98","author":"Butland","year":"2007","journal-title":"Ann Allergy Asthma Immunol"},{"key":"R8-4-20210128","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jaci.2006.10.020","article-title":"Asthma treatment and asthma prevention: a tale of 2 parallel pathways","volume":"119","author":"Martinez","year":"2007","journal-title":"J Allergy Clin Immunol"},{"key":"R9-4-20210128","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/S0140-6736(06)69077-6","article-title":"Bronchiolitis. Review","volume":"368","author":"Smyth","year":"2006","journal-title":"Lancet"},{"key":"R10-4-20210128","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1067\/mai.2003.33","article-title":"Rhinovirus-induced wheezing in infancy: the first sign of childhood asthma?","volume":"111","author":"Kotaniemi-Syrj\u00e4nen","year":"2003","journal-title":"J Allergy Clin Immunol"},{"key":"R11-4-20210128","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1086\/512196","article-title":"Human bocavirus and acute wheezing in children","volume":"44","author":"Allander","year":"2007","journal-title":"Clin Infect Dis"},{"key":"R12-4-20210128","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/ppul.20273","article-title":"Teenage asthma after severe early childhood wheezing: an 11-year prospective follow-up","volume":"40","author":"Hyv\u00e4rinen","year":"2005","journal-title":"Pediatr Pulmonol"},{"key":"R13-4-20210128","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/j.1365-2222.2005.02172.x","article-title":"Allergen-specific sensitization in asthma and allergic diseases in children: the study on farmers' and nonfarmers' children","volume":"35","author":"Remes","year":"2005","journal-title":"Clin Exp Allergy"},{"key":"R14-4-20210128","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/ppul.20058","article-title":"Respiratory morbidity 20 years after RSV infection in infancy","volume":"38","author":"Korppi","year":"2004","journal-title":"Pediatr Pulmonol"},{"key":"R15-4-20210128","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1001\/archpedi.158.11.1070","article-title":"Asthma and lung function 20 years after wheezing in infancy: results from a prospective follow-up study","volume":"158","author":"Piippo-Savolainen","year":"2004","journal-title":"Arch Pediatr Adolesc Med"},{"key":"R16-4-20210128","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1080\/08035250500499440","article-title":"Asthma symptoms in early childhood: what happens then?","volume":"95","author":"Goks\u00f6r","year":"2006","journal-title":"Acta Paediatr"},{"key":"R17-4-20210128","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1002\/ppul.20798","article-title":"Reduced airway function in early adulthood among subjects with wheezing disorder before two years of age","volume":"43","author":"Goks\u00f6r","year":"2008","journal-title":"Pediatr Pulmonol"},{"key":"R18-4-20210128","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1164\/rccm.200504-525OC","article-title":"Outcome of asthma and wheezing in the first 6 years of life: follow-up through adolescence","volume":"172","author":"Morgan","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"R19-4-20210128","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/S0140-6736(07)61379-8","article-title":"Poor airway function in early infancy and lung function by age 22 years: a nonselective longitudinal cohort study","volume":"370","author":"Stern","year":"2007","journal-title":"Lancet"},{"key":"R20-4-20210128","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/S0140-6736(08)61447-6","article-title":"Wheezing and bronchial hyper-responsiveness in early childhood as predictors of newly diagnosed asthma in early adulthood: a longitudinal birth-cohort study","volume":"372","author":"Stern","year":"2008","journal-title":"Lancet"},{"key":"R21-4-20210128","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1183\/09031936.97.10081787","article-title":"Prevalence of asthma symptoms in video and written questionnaires among children in four regions of Finland","volume":"10","author":"Pekkanen","year":"1997","journal-title":"Eur Respir J"},{"key":"R22-4-20210128","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1136\/thorax.57.2.120","article-title":"In search of childhood asthma: questionnaire, tests of bronchial hyperresponsiveness, and clinical evaluation","volume":"57","author":"Remes","year":"2002","journal-title":"Thorax"},{"key":"R23-4-20210128","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1164\/rccm.200307-891OC","article-title":"The relationship between infant airway function, childhood airway responsiveness, and asthma","volume":"169","author":"Turner","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"R24-4-20210128","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1164\/rccm.200805-804OC","article-title":"Childhood asthma and increased airway responsiveness: a relationship that begins in infancy.","volume":"179","author":"Turner","year":"2009","journal-title":"Am J Respir Crit Care Med"},{"key":"R25-4-20210128","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1164\/ajrccm.162.4.9912111","article-title":"A clinical index to define risk of asthma in young children with recurrent wheezing","volume":"162","author":"Castro-Rodr\u00edguez","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"R26-4-20210128","doi-asserted-by":"crossref","first-page":"e255","DOI":"10.1542\/peds.111.3.e255","article-title":"Allergen-specific immunoglobulin E antibodies in wheezing infants: the risk for asthma in later childhood","volume":"111","author":"Kotaniemi-Syrj\u00e4nen","year":"2003","journal-title":"Pediatrics"},{"key":"R27-4-20210128","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.jaci.2004.09.020","article-title":"Atopic characteristics of children with recurrent wheezing at high risk for the development of childhood asthma","volume":"114","author":"Guilbert","year":"2004","journal-title":"J Allergy Clin Immunol"},{"key":"R28-4-20210128","doi-asserted-by":"crossref","first-page":"454","DOI":"10.2500\/aap.2007.28.3022","article-title":"Does early exposure or sensitization to inhalant allergens predict asthma in wheezing infants? A 20-year follow-up","volume":"28","author":"Piippo-Savolainen","year":"2007","journal-title":"Allergy Asthma Proc"},{"key":"R29-4-20210128","doi-asserted-by":"crossref","first-page":"341","DOI":"10.2500\/aap.2006.27.2912","article-title":"Early predictors for adult asthma and lung function abnormalities in infants hospitalized for bronchiolitis: a prospective 18- to 20-year follow-up","volume":"27","author":"Piippo-Savolainen","year":"2006","journal-title":"Allergy Asthma Proc"},{"key":"R30-4-20210128","doi-asserted-by":"crossref","first-page":"163","DOI":"10.2500\/app.2007.28.2946","article-title":"Does blood eosinophilia in wheezing infants predict later asthma? A prospective 18\u201320-year follow-up","volume":"28","author":"Piippo-Savolainen","year":"2007","journal-title":"Allergy Asthma Proc"},{"key":"R31-4-20210128","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1442-200X.2007.02340.x","article-title":"Adult asthma after nonrespiratory syncytial virus bronchiolitis in infancy: subgroup analysis of the 20-year prospective follow-up study","volume":"49","author":"Piippo-Savolainen","year":"2007","journal-title":"Pediatr Int"},{"key":"R32-4-20210128","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/j.1651-2227.2007.00296.x","article-title":"The impact of pre and postnatal smoke exposure on future asthma and bronchial hyper-responsiveness","volume":"96","author":"Goks\u00f6r","year":"2007","journal-title":"Acta Paediatr"},{"key":"R33-4-20210128","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1164\/rccm.200610-1507OC","article-title":"Effect of breastfeeding on lung function in childhood and modulation by maternal asthma and atopy","volume":"176","author":"Guilbert","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"R34-4-20210128","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1093\/oxfordjournals.aje.a009748","article-title":"Influence of parental smoking on respiratory symptoms during the first decade of life: the Tucson Children's Respiratory Study","volume":"149","author":"Stein","year":"1999","journal-title":"Am J Epidemiol"},{"key":"R35-4-20210128","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1164\/rccm.200309-1224OC","article-title":"Persistence of asthma symptoms during adolescence: role of obesity and age at the onset of puberty","volume":"170","author":"Guerra","year":"2004","journal-title":"Am J Respir Crit Care Med"},{"key":"R36-4-20210128","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1111\/j.1399-3038.2008.00758.x","article-title":"Early exposure and sensitization to cat and dog: different effects on asthma risk after wheezing in infancy","volume":"19","author":"Korppi","year":"2008","journal-title":"Pediatr Allergy Immunol"},{"key":"R37-4-20210128","first-page":"433","article-title":"Allergies, infections and the hygiene hypothesis: the epidemiological evidence","volume":"212","author":"Von Mutius","year":"2007","journal-title":"Proc Am Thorac Soc"},{"key":"R38-4-20210128","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/S0140-6736(98)10321-5","article-title":"Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years","volume":"354","author":"Stein","year":"1999","journal-title":"Lancet"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e32832ac00b","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T17:53:39Z","timestamp":1786038819000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-200906000-00004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":37,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2009]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e32832ac00b","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}