{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:59:19Z","timestamp":1793314759228,"version":"4.5.0"},"reference-count":38,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2010,10]]},"DOI":"10.1097\/aci.0b013e32833df9f4","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T06:23:18Z","timestamp":1280902998000},"page":"505-510","source":"Crossref","is-referenced-by-count":290,"title":["Pathogenic role of Demodex mites in blepharitis"],"prefix":"10.1097","volume":"10","author":[{"given":"Jingbo","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hosam","family":"Sheha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scheffer CG","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-16-20210128","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1001\/archderm.1963.01590210056008","article-title":"Demodex folliculorum and blepharitis","volume":"88","author":"Post","year":"1963","journal-title":"Arch Dermatol"},{"key":"R2-16-20210128","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S0738-081X(01)00244-9","article-title":"Demodex folliculorum in development of dermatitis rosaceiformis steroidica and rosacea-related diseases","volume":"20","author":"Basta-Juzbasic","year":"2002","journal-title":"Clin Dermatol"},{"key":"R3-16-20210128","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1046\/j.1365-4362.1998.00218.x","article-title":"The significance of Demodex folliculorum density in rosacea","volume":"37","author":"Erbagci","year":"1998","journal-title":"Int J Dermatol"},{"key":"R4-16-20210128","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jaad.2004.05.034","article-title":"Demodicosis and rosacea: epidemiology and significance in daily dermatologic practice","volume":"52","author":"Forton","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"R5-16-20210128","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1046\/j.1468-3083.2001.00331.x","article-title":"Increased density of Demodex folliculorum and evidence of delayed hypersensitivity reaction in subjects with papulopustular rosacea","volume":"15","author":"Georgala","year":"2001","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"R6-16-20210128","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1046\/j.1525-1470.2003.03006.x","article-title":"Rosacea-like demodicidosis in an immunocompromised child","volume":"20","author":"Morras","year":"2003","journal-title":"Pediatr Dermatol"},{"key":"R7-16-20210128","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1046\/j.1365-4362.2003.01928.x","article-title":"High incidence of demodicidosis in eyelid basal cell carcinomas","volume":"42","author":"Erbagci","year":"2003","journal-title":"Int J Dermatol"},{"key":"R8-16-20210128","first-page":"525","article-title":"Blepharitis due to Demodex: myth or reality?","volume":"22","author":"Kamoun","year":"1999","journal-title":"J Fr Ophtalmol"},{"key":"R9-16-20210128","first-page":"127","article-title":"Demodex folliculorum and Demodex brevis (Acarida) as the factors of chronic marginal blepharitis","volume":"37","author":"Humiczewska","year":"1991","journal-title":"Wiad Parazytol"},{"key":"R10-16-20210128","first-page":"361","article-title":"Demodex folliculorum blepharitis","volume":"65","author":"Coston","year":"1967","journal-title":"Trans Am Ophthalmol Soc"},{"key":"R11-16-20210128","first-page":"914","article-title":"Clinical manifestations of demodicosis","volume":"57","author":"Heacock","year":"1986","journal-title":"J Am Optom Assoc"},{"key":"R12-16-20210128","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000250228","article-title":"The hair follicle mites Demodex folliculorum and Demodex brevis: biology and medical importance: a review","volume":"162","author":"Rufli","year":"1981","journal-title":"Dermatologica"},{"key":"R13-16-20210128","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.ophtha.2009.09.057","article-title":"Correlation between ocular Demodex infestation and serum immunoreactivity to bacillus proteins in patients with facial rosacea","volume":"117","author":"Li","year":"2010","journal-title":"Ophthalmology"},{"key":"R14-16-20210128","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/1523-1747.ep12524458","article-title":"Oral thermal-induced flushing in erythematotelangiectatic rosacea","volume":"76","author":"Wilkin","year":"1981","journal-title":"J Invest Dermatol"},{"key":"R15-16-20210128","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/j.1365-4362.1982.tb00483.x","article-title":"Rosacea flushing","volume":"21","author":"Bernstein","year":"1982","journal-title":"Int J Dermatol"},{"key":"R16-16-20210128","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1111\/j.1365-4632.2007.03336.x","article-title":"Clinical importance of Demodex folliculorum in patients receiving phototherapy","volume":"47","author":"Kulac","year":"2008","journal-title":"Int J Dermatol"},{"key":"R17-16-20210128","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.1167\/iovs.05-0275","article-title":"High prevalence of ocular Demodex in lashes with cylindrical dandruffs","volume":"46","author":"Gao","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R18-16-20210128","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/nm0807-904","article-title":"Rosacea: skin innate immunity gone awry?","volume":"13","author":"Bevins","year":"2007","journal-title":"Nat Med"},{"key":"R19-16-20210128","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1097\/01.ico.0000244870.62384.79","article-title":"Clinical treatment of ocular demodecosis by lid scrub with tea tree oil","volume":"26","author":"Gao","year":"2007","journal-title":"Cornea"},{"key":"R20-16-20210128","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/0002-9394(85)90522-7","article-title":"Demodectic mites and chalazion","volume":"100","author":"English","year":"1985","journal-title":"Am J Ophthalmol"},{"key":"R21-16-20210128","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/S0008-4182(03)80117-5","article-title":"A rare agent of chalazion: demodectic mites","volume":"38","author":"Koksal","year":"2003","journal-title":"Can J Ophthalmol"},{"key":"R22-16-20210128","first-page":"535","article-title":"The hair follicle mites (Demodex spp.). Could they be vectors of pathogenic microorganisms?","volume":"68","author":"Wolf","year":"1988","journal-title":"Acta Derm Venereol"},{"key":"R23-16-20210128","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1111\/j.1365-2133.2007.08028.x","article-title":"Mite-related bacterial antigens stimulate inflammatory cells in rosacea","volume":"157","author":"Lacey","year":"2007","journal-title":"Br J Dermatol"},{"key":"R24-16-20210128","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1167\/iovs.02-0818","article-title":"Kinetic analysis of tear interference images in aqueous tear deficiency dry eye before and after punctal occlusion","volume":"44","author":"Goto","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"R25-16-20210128","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.ajo.2007.01.054","article-title":"Corneal manifestations of ocular Demodex infestation","volume":"143","author":"Kheirkhah","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"R26-16-20210128","first-page":"296","article-title":"Comparison of incidence of Demodex folliculorum on the eyelash follicule in normal people and blepharitis patients","volume":"31","author":"Turk","year":"2007","journal-title":"Turkiye Parazitol Derg"},{"key":"R28-16-20210128","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1097\/ICO.0b013e31805b7eaf","article-title":"Fluorescein dye improves microscopic evaluation and counting of Demodex in blepharitis with cylindrical dandruff.","volume":"26","author":"Kheirkhah","year":"2007","journal-title":"Cornea"},{"key":"R29-16-20210128","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1136\/bjo.2005.072363","article-title":"In vitro and in vivo killing of ocular Demodex by tea tree oil","volume":"89","author":"Gao","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"R30-16-20210128","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.jhin.2004.07.015","article-title":"Assessment of the antibacterial activity of tea tree oil using the European EN 1276 and EN 12054 standard suspension tests","volume":"59","author":"Messager","year":"2005","journal-title":"J Hosp Infect"},{"key":"R31-16-20210128","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.burns.2004.06.006","article-title":"The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model","volume":"30","author":"Edwards-Jones","year":"2004","journal-title":"Burns"},{"key":"R32-16-20210128","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1016\/j.ajic.2003.12.008","article-title":"Staphylococcus aureus and wounds: a review of tea tree oil as a promising antimicrobial","volume":"32","author":"Halcon","year":"2004","journal-title":"Am J Infect Control"},{"key":"R33-16-20210128","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1472-765X.2003.01375.x","article-title":"Antimycotic activity of Melaleuca alternifolia essential oil and its major components","volume":"37","author":"Oliva","year":"2003","journal-title":"Lett Appl Microbiol"},{"key":"R34-16-20210128","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2165\/00128071-200405060-00006","article-title":"Role of antifungal agents in the treatment of seborrheic dermatitis","volume":"5","author":"Gupta","year":"2004","journal-title":"Am J Clin Dermatol"},{"key":"R35-16-20210128","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/jac\/dkh243","article-title":"Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae","volume":"53","author":"Hammer","year":"2004","journal-title":"J Antimicrob Chemother"},{"key":"R36-16-20210128","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1046\/j.1439-0507.2003.00951.x","article-title":"Herbal medicines for treatment of fungal infections: a systematic review of controlled clinical trials","volume":"47","author":"Martin","year":"2004","journal-title":"Mycoses"},{"key":"R37-16-20210128","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1046\/j.1365-2672.2003.02059.x","article-title":"Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil","volume":"95","author":"Hammer","year":"2003","journal-title":"J Appl Microbiol"},{"key":"R38-16-20210128","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1080\/1071576042000220247","article-title":"Anti-inflammatory effects of Melaleuca alternifolia essential oil on human polymorphonuclear neutrophils and monocytes","volume":"38","author":"Caldefie-Chezet","year":"2004","journal-title":"Free Radic Res"},{"key":"R39-16-20210128","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1034\/j.1600-0536.2001.045002065.x","article-title":"Safety, efficacy and provenance of tea tree (Melaleuca alternifolia) oil","volume":"45","author":"Carson","year":"2001","journal-title":"Contact Dermatitis"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e32833df9f4","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:27:07Z","timestamp":1786040827000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-201010000-00016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":38,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e32833df9f4","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}