{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T13:28:56Z","timestamp":1791120536256,"version":"4.1.0"},"reference-count":42,"publisher":"Ovid Technologies (Wolters Kluwer Health)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2011,2]]},"DOI":"10.1097\/aci.0b013e32834232b0","type":"journal-article","created":{"date-parts":[[2010,12,10]],"date-time":"2010-12-10T00:57:36Z","timestamp":1291942656000},"page":"33-38","source":"Crossref","is-referenced-by-count":41,"title":["Mast cell CRAC channel as a novel therapeutic target in allergy"],"prefix":"10.1097","volume":"11","author":[{"given":"Joseph L","family":"Di Capite","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grant J","family":"Bates","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anant B","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"276","reference":[{"key":"R1-8-20210128","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1152\/physrev.1997.77.4.1033","article-title":"Mast cells","volume":"77","author":"Metcalfe","year":"1997","journal-title":"Physiol Rev"},{"key":"R2-8-20210128","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00130832-200406000-00004","article-title":"Mediators of inflammation in the early and the late phase of allergic rhinitis","volume":"4","author":"Hansen","year":"2004","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R3-8-20210128","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/nri1460","article-title":"Mast-cell responses to pathogens","volume":"4","author":"Marshall","year":"2004","journal-title":"Nature Rev Immunol"},{"key":"R4-8-20210128","doi-asserted-by":"crossref","first-page":"B24","DOI":"10.1038\/35037021","article-title":"Signalling through the high-affinity IgE receptor FCepsilonRI","volume":"402","author":"Turner","year":"1999","journal-title":"Nature"},{"key":"R5-8-20210128","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1600-065X.2009.00808.x","article-title":"CRAC channels and Ca2+ signalling in mast cells","volume":"231","author":"Di Capite","year":"2009","journal-title":"Immunol Revs"},{"key":"R6-8-20210128","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1016\/j.cub.2005.05.055","article-title":"STIM is a calcium sensor essential for calcium-store depletion triggered calcium infux","volume":"15","author":"Liou","year":"2005","journal-title":"Curr Biol"},{"key":"R7-8-20210128","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1083\/jcb.200502019","article-title":"STIM1, an essential and conserved component of store-operated Ca2+ channel function","volume":"169","author":"Roos","year":"2005","journal-title":"J Cell Biol"},{"key":"R8-8-20210128","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature04702","article-title":"A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function","volume":"441","author":"Feske","year":"2006","journal-title":"Nature"},{"key":"R9-8-20210128","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1126\/science.1127883","article-title":"CRACM1 is a plasma membrane protein essential for storeoperated calcium entry","volume":"312","author":"Vig","year":"2006","journal-title":"Science"},{"key":"R10-8-20210128","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1146\/annurev.immunol.021908.132550","article-title":"Molecular basis of calcium signalling in lymphocytes: STIM and ORAI","volume":"28","author":"Hogan","year":"2010","journal-title":"Annu Rev Immunol"},{"key":"R11-8-20210128","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1038\/nature04147","article-title":"STIM1 is a calcium sensor that activates CRAC channels and migrates from the calcium store to the plasma membrane","volume":"437","author":"Zhang","year":"2005","journal-title":"Nature"},{"key":"R12-8-20210128","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/ncb0609-669","article-title":"STIMulating store-operated Ca2+ entry","volume":"11","author":"Cahalan","year":"2009","journal-title":"Nature Cell Biol"},{"key":"R13-8-20210128","doi-asserted-by":"crossref","first-page":"22516","DOI":"10.1073\/pnas.0909574106","article-title":"Structural determinants of ion permeation in CRAC channels","volume":"106","author":"McNally","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"R14-8-20210128","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/S0092-8674(00)80282-2","article-title":"The store-operated calcium current ICRAC: nonlinear activation by InsP3 and dissociation from calcium release","volume":"89","author":"Parekh","year":"1997","journal-title":"Cell"},{"key":"R15-8-20210128","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1152\/physrev.00057.2003","article-title":"Store-operated calcium channels.","volume":"85","author":"Parekh","year":"2005","journal-title":"Physiol Rev"},{"key":"R16-8-20210128","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1038\/nature07065","article-title":"Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation.","volume":"454","author":"Luik","year":"2008","journal-title":"Nature"},{"key":"R17-8-20210128","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1016\/j.cell.2007.11.039","article-title":"STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum calcium levels","volume":"131","author":"Brandman","year":"2007","journal-title":"Cell"},{"key":"R18-8-20210128","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/355353a0","article-title":"Depletion of intracellular calcium stores activates a calcium current in mast cells","volume":"355","author":"Hoth","year":"1992","journal-title":"Nature"},{"key":"R19-8-20210128","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/ni1441","article-title":"Increased IgE-dependent mast cell activation and anaphylactic responses in mice lacking the calcium-activated nonselective cation channel TRPM4","volume":"8","author":"Vennekens","year":"2007","journal-title":"Nature Immunol"},{"key":"R20-8-20210128","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.1073\/pnas.92.17.7907","article-title":"Depletion-activated calcium current is inhibited by protein kinase in RBL-2H3 cells","volume":"92","author":"Parekh","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"R21-8-20210128","doi-asserted-by":"crossref","first-page":"25720","DOI":"10.1074\/jbc.M109.022996","article-title":"Protein kinase C-induced phosphorylation of Orai1 regulates the intracellular Ca2+ level via the store-operated Ca2+ channel","volume":"285","author":"Kawasaki","year":"2010","journal-title":"J Biol Chem"},{"key":"R22-8-20210128","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/ni1546","article-title":"Essential function for the calcium sensor STIM1 in mast cell activation and anaphylatic responses","volume":"9","author":"Baba","year":"2008","journal-title":"Nature Immunol"},{"key":"R23-8-20210128","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1038\/ni1550","article-title":"Defective mast cell effector functions in mice lacking the CRACM1 pore subunit of store-operated calcium release-activated calcium channels","volume":"9","author":"Vig","year":"2008","journal-title":"Nature Immunol"},{"key":"R24-8-20210128","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/nrd3136","article-title":"Store-operated CRAC channels: function in health and disease","volume":"9","author":"Parekh","year":"2010","journal-title":"Nature Rev Drug Discov"},{"key":"R25-8-20210128","doi-asserted-by":"crossref","first-page":"48118","DOI":"10.1074\/jbc.M107919200","article-title":"Potent inhibition of NFAT activation and T cell cytokine production by novel low molecular weight pyrazole compounds","volume":"276","author":"Trevillyan","year":"2001","journal-title":"J Biol Chem"},{"key":"R26-8-20210128","doi-asserted-by":"crossref","first-page":"31348","DOI":"10.1074\/jbc.M804942200","article-title":"Sustained activation of the tyrosine kinase Syk by antigen in mast cells requires local Ca2+ influx through Ca2+ release-activated Ca2+ channels","volume":"283","author":"Ng","year":"2008","journal-title":"J Biol Chem"},{"key":"R27-8-20210128","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.4049\/jimmunol.180.4.2233","article-title":"Canonical transient receptor potential 5 channel in conjunction with Orai1 and STIM1 allows Sr2+ entry, optimal influx of Ca2+, and degranulation in a rat mast cell line","volume":"180","author":"Ma","year":"2008","journal-title":"J Immunol"},{"key":"R28-8-20210128","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1016\/j.bbrc.2009.12.139","article-title":"Fyn kinase controls FC\u03b5RI receptor-operated calcium entry necessary for full degranulation in mast cells","volume":"391","author":"Sanchez-Miranda","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"R29-8-20210128","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/j.molimm.2008.11.011","article-title":"L-type Ca2+ channels in mast cells: activation by membrane depolarization and distinct roles in regulating mediator release from store-operated Ca2+ channels","volume":"46","author":"Yoshimaru","year":"2009","journal-title":"Molec Immunol"},{"key":"R30-8-20210128","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1124\/mol.105.021154","article-title":"A pyrazole derivative potently inhibits lymphocyte Ca2+ influx and cytokine production by facilitating transient receptor potential melastatin 4 channel activity","volume":"69","author":"Takezawa","year":"2006","journal-title":"Molec Pharmacol"},{"key":"R31-8-20210128","doi-asserted-by":"crossref","first-page":"12427","DOI":"10.1074\/jbc.M309297200","article-title":"Potent inhibition of Ca2+ release-activated Ca2+ channels and tlymphocyte activation by the pyrazole derivative BTP2","volume":"279","author":"Zitt","year":"2004","journal-title":"Biol Chem"},{"key":"R32-8-20210128","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1096\/fj.08-118935","article-title":"Intercellular calcium wave propagation involving positive feedback between CRAC channels and cysteinyl leukotrienes","volume":"23","author":"DiCapite","year":"2009","journal-title":"FASEB J"},{"key":"R33-8-20210128","doi-asserted-by":"crossref","first-page":"4622","DOI":"10.1074\/jbc.M705002200","article-title":"Local calcium influx through calcium release-activated calcium (CRAC) channels stimulates production of an intracellular messenger and an intercellular pro-inflammatory signal","volume":"283","author":"Chang","year":"2008","journal-title":"J Biol Chem"},{"key":"R34-8-20210128","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/S0091-6749(99)70117-X","article-title":"Quality of life in nasal polyposis","volume":"103","author":"Radenne","year":"1999","journal-title":"J Allergy Clin Immunol"},{"key":"R35-8-20210128","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1097\/00130832-200302000-00001","article-title":"Nasal polyposis: an update.","volume":"3","author":"Pawankar","year":"2003","journal-title":"Curr Opin Allergy Clin Immunol"},{"key":"R36-8-20210128","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.jaci.2009.08.030","article-title":"Targeting CRAC channels and leukotriene receptors provides a novel combination strategy for treating nasal polyposis","volume":"124","author":"Di Capite","year":"2009","journal-title":"J Allergy Clin Immunol"},{"key":"R37-8-20210128","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1152\/japplphysiol.00722.2001","article-title":"Role of capacitative Ca2+ entry in bronchial contraction and remodeling","volume":"92","author":"Sweeney","year":"2002","journal-title":"J Appl Physiol"},{"key":"R38-8-20210128","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1165\/rcmb.2007-0395OC","article-title":"Orai and store-operated calcium influx in human airway smooth muscle cells","volume":"38","author":"Peel","year":"2008","journal-title":"Am J Respir Cell Molec Biol"},{"key":"R39-8-20210128","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1186\/1465-9921-7-119","article-title":"A key role for STIM1 in store operated calcium channel activation in airway smooth muscle","volume":"7","author":"Peel","year":"2006","journal-title":"Respir Res"},{"key":"R40-8-20210128","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1183\/09031936.00054608","article-title":"Properties of a store-operated nonselective cation channel in airway smooth muscle","volume":"32","author":"Helli","year":"2008","journal-title":"Eur Respir J"},{"key":"R41-8-20210128","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1021\/jm990615a","article-title":"3,5-Bis(trifluoromethyl)pyrazoles: a novel class of NFAT transcription factor regulator","volume":"43","author":"Djuric","year":"2000","journal-title":"J Med Chem"},{"key":"R42-8-20210128","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejphar.2007.01.012","article-title":"YM-58483, a selective CRAC channel inhibitor prevents antigen-induced airway eosinophilia and late phase asthmatic responses via Th2 cytokine inhibition in animal models","volume":"560","author":"Yoshino","year":"2007","journal-title":"Eur J Pharmacol"}],"container-title":["Current Opinion in Allergy & Clinical Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.ovid.com\/10.1097\/ACI.0b013e32834232b0","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T18:41:00Z","timestamp":1786041660000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.ovid.com\/00130832-201102000-00008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2011]]}},"URL":"https:\/\/doi.org\/10.1097\/aci.0b013e32834232b0","relation":{},"ISSN":["1528-4050"],"issn-type":[{"value":"1528-4050","type":"print"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}